Abstract:
:Prechemotherapy neuroimaging data are lacking in posttreatment cognitive impairment studies. Breast cancer patients and noncancer controls were scanned prior to chemotherapy during a response inhibition task. Task reaction times and error rates, as well as neuropsychological tests, hospital records, and salivary biomarkers, were investigated, yielding no significant group differences. Significant group differences observed for the functional magnetic resonance imaging (fMRI) data depended on the type of analysis performed, most consistently implicating widespread attenuated activations in patients. The patient group also revealed considerable variability in task-related brain activity. These pretreatment differences highlight the need to understand the effects of confounding variables before considering posttreatment effects. Role of the funding source: The Canadian Breast Cancer Foundation has funded this project. Their contribution was solely financial support.
journal_name
J Clin Exp Neuropsycholjournal_title
Journal of clinical and experimental neuropsychologyauthors
Scherling C,Collins B,Mackenzie J,Bielajew C,Smith Adoi
10.1080/13803395.2012.666227subject
Has Abstractpub_date
2012-01-01 00:00:00pages
543-60issue
5eissn
1380-3395issn
1744-411Xjournal_volume
34pub_type
杂志文章abstract:INTRODUCTION:Stress is a well-known determinant of cognitive performance in both younger and older adults. However, the moderating effect of pathological aging on this relationship remains insufficiently documented. We hypothesize that mild cognitive impairment (MCI) and Alzheimer's disease (AD) patients will report hi...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803395.2018.1564250
更新日期:2019-05-01 00:00:00
abstract::The face is probably the single most important visual object. It is the main cue for identifying familiar people and crucial in nonverbal communication. Face recognition can be demonstrated in newborn babies, suggesting that face recognition is to some degree 'hard-wired' in the brain. Also, neurological disease can s...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1076/jcen.21.3.312.917
更新日期:1999-06-01 00:00:00
abstract::A series of 53 patients was studied using a battery of tests and a neurobehavioral rating scale on average 4 months after closed-head injury (CHI). Social outcome was assessed 1 year after injury by interviewing a family member. The results supported the hypothesis that tests of flexibility and programming rather than...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1080/01688639408402643
更新日期:1994-06-01 00:00:00
abstract::Neurocognitive assessment is frequently used as a basis for making determinations regarding a person's ability to work; yet, to our knowledge, a review of the association between neurocognition and employment status has not been conducted. For this review, we utilized meta-analysis to quantify objectively the associat...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章,meta分析,评审
doi:10.1076/jcen.25.8.1186.16723
更新日期:2003-12-01 00:00:00
abstract::Like controls, a Closed-Head Injury (CHI) group learned quickly to press a button during a 3-s warning stimulus in order to avoid a noxious buzzer. In a similar task, however, the CHI group had greater difficulty achieving the learning criterion compared to controls when required to prevent an innocuous visual display...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/01688639508405150
更新日期:1995-08-01 00:00:00
abstract::After a review of Arthur Benton's conceptual and methodological contributions to the understanding of normal and pathological development, we discuss agenesis of the corpus callosum (CC), criteria for potential neuroanatomical compensatory mechanisms in CC agenesis, and the results of an examination of magnetic resona...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803390802209954
更新日期:2009-02-01 00:00:00
abstract::The ultimate objective of the present investigation was to improve the detection of depression in multiple sclerosis (MS) by comparing common self-report depression measures to a new, modified measure, which takes into account the contribution that symptoms of MS may have on individuals' reports. There has been a long...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803395.2015.1063591
更新日期:2015-01-01 00:00:00
abstract::The literature suggests that nondeclarative, or nonconscious, learning might be impaired among HIV-seropositive (HIV+) individuals compared with HIV-seronegative (HIV-) matched control groups, but these studies have included relatively few women. We administered measures of motor skill and probabilistic learning, task...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803395.2010.493150
更新日期:2011-01-01 00:00:00
abstract::Prospective monitoring of posttraumatic amnesia (PTA) status is recommended following traumatic brain injury (TBI). Use of patients' subjective reports is, however, still common and necessary in some circumstances. It is therefore important to understand how patients' self-reported first memories relate to prospective...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803395.2018.1490392
更新日期:2019-03-01 00:00:00
abstract::Several studies have reported asymmetric cognitive profiles in patients with Alzheimer's disease (AD), but these results have almost exclusively been found using non-memory cognitive instruments. The present study investigated whether AD patients who display lateralized profiles on non-memory cognitive instruments als...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1076/jcen.23.2.164.1207
更新日期:2001-04-01 00:00:00
abstract::The role of age of acquisition (AoA) and other variables classically supposed to influence lexical semantic tasks is explored in Alzheimer's disease (AD) patients. A naming test that included living and nonliving items was given to patients and controls. Measures of AoA of the test items were obtained from normal subj...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1076/jcen.24.6.755.8407
更新日期:2002-09-01 00:00:00
abstract::Time disorientation is a common feature of anterograde memory disorder caused by brain illness. This observation suggests that the subjective time constructions used to organize events are strongly dependent upon memory storage processes. This study evaluated one prominent cognitive theory of time estimation from the ...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/01688638908400927
更新日期:1989-10-01 00:00:00
abstract::We examined the sensitivity and specificity of the Wisconsin Card Sorting Test (WCST) as a measure of frontal lobe damage in 91 subjects with stable focal brain lesions. Anatomical information about the location and extent of brain damage was obtained from MR and CT transparencies. No significant differences in WCST p...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/01688639108405107
更新日期:1991-11-01 00:00:00
abstract::We investigated age-related improvement in speed and accuracy of complex language comprehension with 361 children attending kindergarten and the 2nd, 4th, 6th, 7th, and 8th grades. Language comprehension was measured using both the neuropsychological procedure proposed by Luria (1966, 1980) and an adapted version of t...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803390701523091
更新日期:2008-05-01 00:00:00
abstract::Several neurocognitive studies have indicated that children with attention-deficit/hyperactivity disorder (ADHD) exhibit cognitive deficits in perceptual timing functions; however, only a few electroencephalographic studies have investigated their time reproduction abilities. In the present research, 15 children with ...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803395.2017.1406897
更新日期:2018-09-01 00:00:00
abstract::Prospective memory (PM), the memory for future intentions, is an essential component of many day-to-day activities. PM accuracy has consistently been found to decline as a function of age and is further impaired in Alzheimer's disease (AD). In the present study, subjective PM failures, PM accuracy, and cost of carryin...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803395.2013.844772
更新日期:2013-01-01 00:00:00
abstract::A mailed questionnaire, sent routinely to discharged stroke patients, divided left-hemisphere (n = 68) and right-hemisphere (n = 77) patients into three groups of general help dependency in basic activities-of-daily-life skills. A subsample of 29 patients was visited at home and asked to reanswer the questionnaire und...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/01688638808408245
更新日期:1988-08-01 00:00:00
abstract::The study aimed to provide independent data on the specificity of the Nonverbal Medical Symptom Validity Test (NV-MSVT; Green, 2008 ), a new test that combines conventional decision making based on cutoffs with profile analyses in order to identify invalid test performance and to reduce false positive classifications....
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803390902791653
更新日期:2010-01-01 00:00:00
abstract::This study examined the contribution of object perception and spatial localization to functional dependence among Alzheimer's disease (AD) patients. Forty patients with probable AD completed measures assessing verbal recognition memory, working memory, object perception, spatial localization, semantic knowledge, and g...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803390591001034
更新日期:2006-08-01 00:00:00
abstract::Cognitive and neurophysiological correlates of arithmetic calculation, concepts, and applications were examined in 41 adolescents, ages 12-15 years. Psychological and task-related EEG measures which correctly distinguished children who scored low vs. high (using a median split) in each arithmetic subarea were interpre...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/01688638708410769
更新日期:1987-10-01 00:00:00
abstract::Using both clinical and nonclinical samples, we investigated the effects of nondominant hand completion of copy and memory components on the Wechsler Memory Scale-Fourth Edition (WMS-IV) Visual Reproduction (VR) subtest. Part I of the study revealed statistically significant intermanual differences on the copy compone...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803395.2013.789827
更新日期:2013-01-01 00:00:00
abstract::We examined the prevalence and correlates of anomalous motor speed asymmetry in 104 right-handed patients with a diagnosis of probable Alzheimer's disease (AD). On the Halstead-Reitan Finger Tapping Test, over 60% of the AD patients exhibited notable departures from expected finger tapping asymmetry; 26% displayed an ...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/01688639608408267
更新日期:1996-02-01 00:00:00
abstract::Patients affected by Alzheimer's disease (DAT) showed considerable difficulties assessing the numerosity of complex dot patterns (up to 30 dots). Patients' and controls' performance was found to be modulated by the spatial array of dot patters. Dots presented in curved lines were easier to count than dots in circle ar...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803390591000819
更新日期:2006-07-01 00:00:00
abstract::This article reports on the development and validation of a novel, objective test of judgment for use with older adults. The Test of Practical Judgment (TOP-J) is an open-ended measure that evaluates judgment related to safety, medical, social/ethical, and financial issues. Psychometric features were examined in a sam...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13825580601025908
更新日期:2007-10-01 00:00:00
abstract::Proficient, nonnative English-speaking neurosurgery candidates are assessed for language function in English. In order to understand whether it is necessary to also assess native-language function, we examined the influence of native language on the bilingual language network of early, proficient bilinguals using func...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803390902766879
更新日期:2009-11-01 00:00:00
abstract:INTRODUCTION:Language dysfunction has recently been suggested to be one route to alexithymia, an impairment in recognizing and communicating one's own emotions. Neuropsychological evidence is needed to investigate the possibility that acquired language problems could underlie acquired alexithymia. METHOD:This project ...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803395.2020.1770703
更新日期:2020-07-01 00:00:00
abstract::Cross-cultural differences may affect performance on neuropsychological tests, even on those, which are non-verbal. We examined the appropriateness of the Hooper Visual Organization Test (HVOT) for use in the Greek population. In doing so, we sought to establish the internal consistency of its items, determine the inf...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803390591004374
更新日期:2006-08-01 00:00:00
abstract::In spite of demonstrated validity, Halstead's Category Test has been criticized as overly time consuming. In order to evaluate this assumption, groups of severely head-injured and general neurological cases were administered the Category Test as part of routine evaluation, and the time to completion of the test was re...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/01688638608405190
更新日期:1986-12-01 00:00:00
abstract::This study examined the relationship between image vividness and psychophysiological responses to trauma-related stimuli in participants with Posttraumatic Stress Disorder (PTSD). An auditory stimulus related to a shared trauma was presented to participants with and without PTSD and physiological parameters (heart rat...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1076/jcen.21.1.39.946
更新日期:1999-02-01 00:00:00
abstract:BACKGROUND:Patients with eating disorders favor immediate gratification and ignore long-term negative consequences. This study investigated decision making in bulimia nervosa using the Iowa Gambling Task (IGT) and skin conductance responses (SCR). METHOD:A total of 26 bulimia nervosa patients and 51 healthy controls t...
journal_title:Journal of clinical and experimental neuropsychology
pub_type: 杂志文章
doi:10.1080/13803390802251378
更新日期:2009-05-01 00:00:00