Abstract：
:During the past few decades, the novel biotherapeutic agents such as peptides and proteins have been contributed to the treatment of several diseases. However, their oral absorption is significantly limited due to their poor delivery through the intestinal mucosa. Therefore, the feasible approaches are needed for improving the oral bioavailability of biodrugs. Recently, cell-penetrating peptides (CPPs) such as HIV-1 Tat, penetratin and oligoarginine are considered as a useful tool for the intracellular delivery of therapeutic macromolecules. Hence, it was expected that the ability of CPPs may be applicable to enhance the absorption of biodrugs through intestinal epithelial membrane. CPPs are likely to become powerful tools for overcoming the low permeability of therapeutic peptides and proteins through the intestinal membrane, the major barrier to their oral delivery. Further advantage of this promising strategy is that this successful intestinal absorption could be achieved by more convenient methodology, coadministration of CPP with drugs via intermolecular interaction among them. Hereafter, the further establishment of delivery system based on CPPs is required to realize the development of the oral forms of therapeutic peptides and proteins. The aim here is to introduce our vision focusing on oral biodrug delivery by the use of CPPs as potential peptide carrier in order to provide new information in the design and development of new oral delivery systems for novel biotherapeutics.
journal_name
Adv Drug Deliv Revjournal_title
Advanced drug delivery reviewsauthors
Khafagy el-S,Morishita Mdoi
10.1016/j.addr.2011.12.014subject
Has Abstractpub_date
2012-05-01 00:00:00pages
531-9issue
6eissn
0169-409Xissn
1872-8294pii
S0169-409X(11)00308-5journal_volume
64pub_type
杂志文章,评审abstract：:Human genome sequencing revealed that only ~1.5% of the DNA sequence coded for proteins. More and more evidence has uncovered that a substantial part of the 98.5% so-called "junk" DNAs actually code for noncoding RNAs. Two milestones, chemical drugs and protein drugs, have already appeared in the history of drug devel...
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journal_title：Advanced drug delivery reviews
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更新日期：2010-03-18 00:00:00
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更新日期：2018-09-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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