Targeting and therapeutic peptide-based strategies for polycystic kidney disease.

Abstract:

:Polycystic kidney disease (PKD) is characterized by progressive cyst growth and is a leading cause of renal failure worldwide. Currently, there are limited therapeutic options available to PKD patients, and only one drug, tolvaptan, has been FDA-approved to slow cyst progression. Similar to other small molecule drugs, however, tolvaptan is costly, only moderately effective, and causes adverse events leading to high patient dropout rates. Peptides may mitigate many drawbacks of small molecule drugs, as they can be highly tissue-specific, biocompatible, and economically scaled-up. Peptides can function as targeting ligands that direct therapies to diseased renal tissue, or be potent as therapeutic agents themselves. This review discusses various aberrant signaling pathways in PKD and renal receptors that can be potential targets of peptide-mediated strategies. Additionally, peptides utilized in other kidney applications, but may prove useful in the context of PKD, are highlighted. Insights into novel peptide-based solutions that have potential to improve clinical management of PKD are provided.

journal_name

Adv Drug Deliv Rev

authors

Wang J,Tripathy N,Chung EJ

doi

10.1016/j.addr.2020.08.011

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

176-189

eissn

0169-409X

issn

1872-8294

pii

S0169-409X(20)30122-8

journal_volume

161-162

pub_type

杂志文章,评审
  • Mathematical and pharmacokinetic modelling of epidermal and dermal transport processes.

    abstract::Topical delivery to the various regions of the skin and underlying tissues, transdermal drug delivery and dermal exposure to environmental chemicals are important areas of research. Mathematical models of epidermal and dermal transport, involving penetration of a solute through various layers of the skin, metabolism i...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2012.04.009

    authors: Anissimov YG,Jepps OG,Dancik Y,Roberts MS

    更新日期:2013-02-01 00:00:00

  • Oral biodrug delivery using cell-penetrating peptide.

    abstract::During the past few decades, the novel biotherapeutic agents such as peptides and proteins have been contributed to the treatment of several diseases. However, their oral absorption is significantly limited due to their poor delivery through the intestinal mucosa. Therefore, the feasible approaches are needed for impr...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2011.12.014

    authors: Khafagy el-S,Morishita M

    更新日期:2012-05-01 00:00:00

  • Culture of organized cell communities.

    abstract::Cells cultured in vitro will tend to retain their differentiated phenotype under conditions that resemble their natural in vivo environment, for example, when cultured on polymer scaffolds in tissue culture bioreactors. In this chapter, we define organized cell communities as three-dimensional in vitro grown cell-poly...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章

    doi:10.1016/s0169-409x(98)00017-9

    authors: Vunjak-Novakovic G,Freed LE

    更新日期:1998-08-03 00:00:00

  • Radiopharmaceutical chemistry for positron emission tomography.

    abstract::Molecular imaging is an emerging technology that allows the visualization of interactions between molecular probes and biological targets. Molecules that either direct or are subject to homeostatic controls in biological systems could be labeled with the appropriate radioisotopes for the quantitative measurement of se...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2010.09.007

    authors: Li Z,Conti PS

    更新日期:2010-08-30 00:00:00

  • Recent developments in micro- and nanofabrication techniques for the preparation of amorphous pharmaceutical dosage forms.

    abstract::Nano- and microfabrication techniques have been widely explored in the textile, polymer and biomedical arenas, although more recently these systems have attracted considerable interest as drug delivery vehicles with concomitant considerations of physical characterization, scalability, stability and drug release. In th...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2016.01.003

    authors: Qi S,Craig D

    更新日期:2016-05-01 00:00:00

  • Antibody-directed enzyme prodrug therapy (ADEPT): a review.

    abstract::Antibody-directed enzyme prodrug therapy (ADEPT) is a therapeutic strategy which aims to improve the selectivity of anticancer drugs. ADEPT is a two-step antibody targeting system that has benefits over a one-step chemo-, toxin- or radioimmunoconjugate. The basic principles of ADEPT are discussed alongside the require...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章

    doi:10.1016/s0169-409x(97)00032-x

    authors: Springer CJ,Niculescu-Duvaz I I

    更新日期:1997-07-07 00:00:00

  • Potential of endogenous regenerative technology for in situ regenerative medicine.

    abstract::Endogenous regenerative technology (Endoret) involves the use of patient's own biologically active proteins, growth factors and biomaterial scaffolds for therapeutic purposes. This technology provides a new approach for the stimulation and acceleration of tissue healing and bone regeneration. The versatility and bioco...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2010.01.001

    authors: Anitua E,Sánchez M,Orive G

    更新日期:2010-06-15 00:00:00

  • Functional electrospun nanofibrous scaffolds for biomedical applications.

    abstract::Functional nanofibrous scaffolds produced by electrospinning have great potential in many biomedical applications, such as tissue engineering, wound dressing, enzyme immobilization and drug (gene) delivery. For a specific successful application, the chemical, physical and biological properties of electrospun scaffolds...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2007.04.021

    authors: Liang D,Hsiao BS,Chu B

    更新日期:2007-12-10 00:00:00

  • Molecular imprinting within hydrogels.

    abstract::Hydrogels have been used primarily in the pharmaceutical field as carriers for delivery of various drugs, peptides and proteins. These systems have included stimuli-responsive gels that exhibit reversible swelling behavior and hence can show modulated release in response to external stimuli such as pH, temperature, io...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/s0169-409x(01)00246-0

    authors: Byrne ME,Park K,Peppas NA

    更新日期:2002-01-17 00:00:00

  • Biopolymer stereocomplexes.

    abstract::A polymer stereocomplex is defined as a stereoselective interaction between two complementing stereoregular polymers, that interlock and form a new composite, demonstrating altered physical properties in comparison to the parent polymers. The main interactions, resulting in the complexation, are suggested to rely on s...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/s0169-409x(03)00042-5

    authors: Slager J,Domb AJ

    更新日期:2003-04-25 00:00:00

  • Disulfide bridge based PEGylation of proteins.

    abstract::PEGylation is a clinically proven strategy for increasing the therapeutic efficacy of protein-based medicines. Our approach to site-specific PEGylation exploits the thiol selective chemistry of the two cysteine sulfur atoms from an accessible disulfide. It involves two key steps: (1) disulfide reduction to release the...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2007.06.014

    authors: Brocchini S,Godwin A,Balan S,Choi JW,Zloh M,Shaunak S

    更新日期:2008-01-03 00:00:00

  • Molecular imaging in stem cell-based therapies of cardiac diseases.

    abstract::In the past 15years, despite that regenerative medicine has shown great potential for cardiovascular diseases, the outcome and safety of stem cell transplantation has shown controversial results in the published literature. Medical imaging might be useful for monitoring and quantifying transplanted cells within the he...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2017.07.012

    authors: Li X,Hacker M

    更新日期:2017-10-01 00:00:00

  • Ocular delivery of nucleic acids: antisense oligonucleotides, aptamers and siRNA.

    abstract::Nucleic acids have gained a lot of interest for the treatment of ocular diseases. The first to enter in clinic has been Vitravene an antisense oligonucleotide for the treatment of cytomegalovirus (CMV) infection and more recently, research on aptamers have led to the marketing of anti-vascular endothelial growth facto...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2006.07.020

    authors: Fattal E,Bochot A

    更新日期:2006-11-15 00:00:00

  • The application of mesenchymal stem cells to treat thermal and radiation burns.

    abstract::Mesenchymal stem cells (MSCs) have been developed for a number of indications due to their regenerative and anti-inflammatory phenotypes and their utility is enhanced by the fact that allogeneic transplant is feasible with this cell type. Animal studies and early human cases indicate that this has the potential to be ...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2017.10.003

    authors: Rodgers K,Jadhav SS

    更新日期:2018-01-01 00:00:00

  • Are there predictors of Remicade treatment success or failure?

    abstract::Infliximab (Remicade) is an antitumor necrosis factor (TNF) therapy effective in both induction and maintenance of remission in Crohn's disease. Identifying predictors of response or relapse to infliximab is important given the potential toxicities and cost of this therapy. Currently available data suggest that concur...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2004.08.006

    authors: Su C,Lichtenstein GR

    更新日期:2005-01-06 00:00:00

  • Microemulsion-based media as novel drug delivery systems.

    abstract::Microemulsions are clear, stable, isotropic mixtures of oil, water and surfactant, frequently in combination with a cosurfactant. These systems are currently of interest to the pharmaceutical scientist because of their considerable potential to act as drug delivery vehicles by incorporating a wide range of drug molecu...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/s0169-409x(00)00103-4

    authors: Lawrence MJ,Rees GD

    更新日期:2000-12-06 00:00:00

  • In vivo efficacy and safety of skin electroporation.

    abstract::This article reviews the studies on skin electroporation carried out in vivo in animals and emphasizes its potential therapeutic applications for transdermal and topical drug delivery. In agreement with in vitro studies, transport across skin due to high-voltage pulses in vivo was shown to increase by orders of magnit...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章

    doi:10.1016/s0169-409x(98)00064-7

    authors: Vanbever R,Préat V V

    更新日期:1999-01-04 00:00:00

  • Preclinical safety and efficacy models for pulmonary drug delivery of antimicrobials with focus on in vitro models.

    abstract::New pharmaceutical formulations must be proven as safe and effective before entering clinical trials. Also in the context of pulmonary drug delivery, preclinical models allow testing of novel antimicrobials, reducing risks and costs during their development. Such models allow reducing the complexity of the human lung,...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2014.10.011

    authors: Hittinger M,Juntke J,Kletting S,Schneider-Daum N,de Souza Carvalho C,Lehr CM

    更新日期:2015-05-01 00:00:00

  • Clinical application of microencapsulated islets: actual prospectives on progress and challenges.

    abstract::After 25 years of intense pre-clinical work on microencapsulated intraperitoneal islet grafts into non-immunosuppressed diabetic recipients, the application of this procedure to patients with type 1 diabetes mellitus has been a significant step forward. This result, achieved in a few centers worldwide, underlies the s...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2013.09.020

    authors: Calafiore R,Basta G

    更新日期:2014-04-01 00:00:00

  • Mechanisms of β-lactam antimicrobial resistance and epidemiology of major community- and healthcare-associated multidrug-resistant bacteria.

    abstract::Alexander Fleming's discovery of penicillin heralded an age of antibiotic development and healthcare advances that are premised on the ability to prevent and treat bacterial infections both safely and effectively. The resultant evolution of antimicrobial resistant mechanisms and spread of bacteria bearing these geneti...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2014.08.003

    authors: Tang SS,Apisarnthanarak A,Hsu LY

    更新日期:2014-11-30 00:00:00

  • Challenges and strategies in anti-cancer nanomedicine development: An industry perspective.

    abstract::Successfully translating anti-cancer nanomedicines from pre-clinical proof of concept to demonstration of therapeutic value in the clinic is challenging. Having made significant advances with drug delivery technologies, we must learn from other areas of oncology drug development, where patient stratification and targe...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2016.04.025

    authors: Hare JI,Lammers T,Ashford MB,Puri S,Storm G,Barry ST

    更新日期:2017-01-01 00:00:00

  • Response of contrast agents to ultrasound.

    abstract::Microbubbles are used as ultrasonic contrast agents that enhance the ultrasound signals of the vascular bed. The recent development of site-targeted microbubbles opened up the possibility for molecular imaging as well as localised drug and gene delivery. Initially the microbubbles' physical properties and their respon...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2008.03.011

    authors: Sboros V

    更新日期:2008-06-30 00:00:00

  • Arterial gene transfer of naked DNA for therapeutic angiogenesis: early clinical results.

    abstract::Patients with critical limb ischemia constitute a potential target population for therapeutic angiogenesis. Because the growth of new collateral vessels can be achieved in a time interval of 1 month or less, these patients are suitable candidates for treatment with non-viral vectors intended to yield short-term gene e...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章

    doi:10.1016/s0169-409x(97)00115-4

    authors: Isner JM

    更新日期:1998-03-02 00:00:00

  • Drug encapsulated polymeric microspheres for intracranial tumor therapy: A review of the literature.

    abstract::Despite intensive surgical excision, radiation therapy, and chemotherapy, the current life expectancy for patients diagnosed with glioblastoma multiforme is only 12 to 15months. One of the approaches being explored to increase chemotherapeutic efficacy is to locally deliver chemotherapeutics encapsulated within degrad...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2015.04.008

    authors: Floyd JA,Galperin A,Ratner BD

    更新日期:2015-08-30 00:00:00

  • Barriers to and new approaches for gene therapy and gene delivery in cystic fibrosis.

    abstract::Clinical trials of gene therapy for cystic fibrosis suggest that current levels of gene transfer efficiency are probably too low to result in clinical benefit, largely as a result of the barriers faced by gene transfer vectors within the airways. The respiratory epithelium has evolved a complex series of extracellular...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/s0169-409x(02)00145-x

    authors: Ferrari S,Geddes DM,Alton EW

    更新日期:2002-12-05 00:00:00

  • Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations.

    abstract::Solid lipid nanoparticles (SLN) were developed at the beginning of the 1990 s as an alternative carrier system to emulsions, liposomes and polymeric nanoparticles. The paper reviews advantages-also potential limitations-of SLN for the use in topical cosmetic and pharmaceutical formulations. Features discussed include ...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/s0169-409x(02)00118-7

    authors: Müller RH,Radtke M,Wissing SA

    更新日期:2002-11-01 00:00:00

  • Physical and mechanical properties of PLA, and their functions in widespread applications - A comprehensive review.

    abstract::Poly(lactic acid) (PLA), so far, is the most extensively researched and utilized biodegradable aliphatic polyester in human history. Due to its merits, PLA is a leading biomaterial for numerous applications in medicine as well as in industry replacing conventional petrochemical-based polymers. The main purpose of this...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2016.06.012

    authors: Farah S,Anderson DG,Langer R

    更新日期:2016-12-15 00:00:00

  • Microdialysis assessment of drug delivery systems for vitreoretinal targets.

    abstract::Posterior segment drug delivery challenges inherent in the treatment of many sight-threatening diseases have become increasingly apparent. Therapeutic interventions for ocular diseases such as neovascular retinopathies, inflammatory and/or infectious diseases may involve drug delivery to vitreoretinal targets. An impo...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2005.09.008

    authors: Duvvuri S,Rittenhouse KD,Mitra AK

    更新日期:2005-12-13 00:00:00

  • Photochemical mechanisms of light-triggered release from nanocarriers.

    abstract::Over the last three decades, a handful of photochemical mechanisms have been applied to a large number of nanoscale assemblies that encapsulate a payload to afford spatio-temporal and remote control over activity of the encapsulated payload. Many of these systems are designed with an eye towards biomedical application...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2012.02.006

    authors: Fomina N,Sankaranarayanan J,Almutairi A

    更新日期:2012-08-01 00:00:00

  • Disruption of the circadian system by environmental factors: Effects of hypoxia, magnetic fields and general anesthetics agents.

    abstract::The biological clock of mammals is under the control of external factors, social life and the environment, and of internal genetic factors. When the biological clock of an individual is no longer in phase with its environment, either because there is no longer any harmony (desynchronization) between the two systems (s...

    journal_title:Advanced drug delivery reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.addr.2010.06.005

    authors: Touitou Y,Coste O,Dispersyn G,Pain L

    更新日期:2010-07-31 00:00:00