Abstract：
BACKGROUND:Glioblastoma multiforme (GBM) is the most aggressive type of primary brain tumor. It is a rapidly progressive, highly recurrent, fatal intracranial neoplasm, and the demand for novel treatment is urgent. Valproic acid (VPA) is a potential anticancer agent that belongs to a class of histone deacetylase (HDAC) inhibitors, targeting the epigenetic control of gene functions in cancer cells. This drug has been administered for the prevention or treatment of seizure disorder in GBM patients; therefore, a retrospective analysis may further our understanding of the effect of VPA on GBM patients. MATERIALS AND METHODS:A retrospective analysis of 102 patients with GBM was conducted to study the effects of VPA on disease outcome. Tumor samples from seven patients receiving VPA treatment between the first and second operations were obtained in order to verify the HDAC inhibitory activity of VPA in these patients. RESULTS:In univariate analysis, administration of VPA within 2 weeks of initial diagnosis seemed to confer a survival benefit. However, stratified analysis according to chemotherapy showed that VPA did not have significant impact on the GBM patients' overall survival. Analysis of tissue samples from these patients revealed that a small subset of patients had increased histone acetylation after VPA treatment. CONCLUSION:VPA treatment, when administered according to a protocol targeting seizure control, may result in HDAC inhibition in a small subset of patients, but does not significantly affect overall patient survival. Early administration of VPA as an adjunct to temozolomide chemotherapy may have its merits, but the optimal dosing schedule and target serum level require further investigation.
journal_name
Br J Neurosurgjournal_title
British journal of neurosurgeryauthors
Tsai HC,Wei KC,Tsai CN,Huang YC,Chen PY,Chen SM,Lu YJ,Lee STdoi
10.3109/02688697.2011.638996subject
Has Abstractpub_date
2012-06-01 00:00:00pages
347-54issue
3eissn
0268-8697issn
1360-046Xjournal_volume
26pub_type
杂志文章abstract：:Racial differences in the incidence and rate of rupture of intracranial aneurysms are well recognized. A retrospective study of racial differences between Maori and European New Zealanders presenting to the Auckland Regional Neurosurgical Unit between 1985 and 1990 was conducted. It was found that the incidence per 10...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.3109/02688699309103475
更新日期：1993-01-01 00:00:00
abstract：:The goal of this study was to assess the diagnostic accuracy of 16-row multislice computed tomography angiography (CTA) compared with digital subtraction angiography (DSA) in the detection of aneurysm remnants and arterial patency after clipping of intracranial aneurysms. Thirty-seven consecutive patients with 40 clip...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.1080/02688690701630108
更新日期：2008-02-01 00:00:00
abstract：:We present a case of recurrent vago-glossopharyngeal neuralgia after previous surgery, treated successfully with microvascular decompression using intra-operative neurophysiology monitoring. ...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.3109/02688697.2015.1039486
更新日期：2015-01-01 00:00:00
abstract：:A 46-year old female patient presented with a left-sided superior temporal quadrantanopia due to a recurrent craniopharyngioma. The location of the recurrence was unusual. Imaging showed an enlarged left optic nerve, suggestive of a recurrent intra-optic craniopharyngioma. It was possible to remove the tumour without ...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.1080/02688697.2020.1760207
更新日期：2020-05-12 00:00:00
abstract：OBJECTIVE:The aim of this study was to identify independent anatomic, morphologic and hemodynamic features of the ACoA (anterior communicating artery) complex that serve as risk factors for the occurrence of ACoA aneurysms. METHODS:Fifteen consecutive patients with 15 ACoA aneurysms were included. Computational fluid ...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.1080/02688697.2020.1821867
更新日期：2020-09-29 00:00:00
abstract：:This study evaluated the clinical outcomes following venous ligation for the treatment of dural arteriovenous fistulas (DAVF) with leptomeningeal or cortical venous drainage. The authors conducted a single-centre, retrospective study of 15 patients with DAVF treated consecutively between 1990 and 2000. There were eigh...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.1080/0268869031000153125
更新日期：2003-06-01 00:00:00
abstract：:A case of dysplastic cerebellar gangliocytoma recurring after 20 years and representing with subarachnoid haemorrhage is described. Evidence in favour of a neoplastic pathogenesis is presented. ...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.3109/02688699209002919
更新日期：1992-01-01 00:00:00
abstract：OBJECTIVE:To explore the clinical significance of dynamic monitoring of cerebrospinal fluid (CSF) and serum Lactic acid（Lac), neuron-specific enolase (NSE), and the blood-brain barrier (BBB) index in evaluating the condition and prognosis after a severe traumatic brain injury (TBI). METHODS:A total of 52 severe TBI pa...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.1080/02688697.2020.1823938
更新日期：2020-10-05 00:00:00
abstract：:The authors present a 37-year-old lady with symptoms and signs suggestive of benign intracranial hypertension (BIH). Routine CT and MRI scans were normal. Further investigations were performed with magnetic resonance venography (MRV) and cerebral venography. These revealed obstruction of the right transverse sinus wit...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.1080/02688690310001627821
更新日期：2003-12-01 00:00:00
abstract：:Anterior sacral meningocele is a rare congenital condition. Among 177 individuals familial occurrence was reported only seven times. In this report a family in which five members had anterior sacral meningoceles is presented and an autosomal dominant inheritance is suggested. ...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.3109/02688699009000683
更新日期：1990-01-01 00:00:00
abstract：:Selecting patients who will benefit from a permanent CSF diversion procedure in benign intracranial hypertension (BIH) or communicating hydrocephalus due to normal pressure hydrocephalus (NPH) has inherent problems. The percutaneous introduction of a lumbar subcutaneous shunt (LSS) under local anaesthesia facilitates ...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.1080/02688690802007883
更新日期：2008-10-01 00:00:00
abstract：:Choroid plexus xanthogranulomas are uncommon lesions that occur almost exclusively in adults; most of them constitute incidental autopsy findings. A case of symptomatic bilateral xanthogranulomas of choroid plexus in a 6 year-old girl with progressive visual loss is reported. Theories on the pathogenesis of this entit...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.1080/02688690042960
更新日期：2000-02-01 00:00:00
abstract：:Background: Bow hunter's syndrome (BHS), also known as rotational vertebral artery occlusion syndrome, is rare. Occasionally, it combines with dissection/pseudoaneurysm of the ipsilateral VA.Methods: We report a case of BHS combined with ipsilateral VA dissection/pseudoaneurysm and review eight similar cases reported ...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.1080/02688697.2020.1718604
更新日期：2020-02-03 00:00:00
abstract：:Early changes of the activity of enzymes such as creatine kinase in the cerebrospinal fluid (CSF) or serum are often investigated after head injuries to assess the extent of brain damage and establish a reliable prognosis. The purpose of the present study was to determine levels of creatine kinase isoenzyme CK-BB in t...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.3109/02688698808992666
更新日期：1988-01-01 00:00:00
abstract：:Total excision is usually the recommended treatment for central neurocytomas. The role of radiation therapy in their management is controversial, and is usually reserved for partially resected or recurrent tumours. Long-term outcome was studied in patients with central neurocytoma who were treated with radiation thera...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.1080/02688690220131714
更新日期：2002-04-01 00:00:00
abstract：BACKGROUND:Maintenance of on-call referrals databases is on the rise in neurosurgical units across the UK and helps provide data to estimate workload. We hypothesize that these databases underestimate the workload and propose the use of the number of telephone calls to the on-call registrar as an easily obtainable and ...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.3109/02688697.2012.743966
更新日期：2013-06-01 00:00:00
abstract：:Background: Radiation exposure is a known risk factor for meningioma but there are no data regarding hemangiopericytoma and radiation exposure.Case Description: We report a 29-year-old pineoblastoma patient diagnosed with a hemangiopericytoma at a different location, after a successful surgical excision and adjuvant r...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.1080/02688697.2020.1759779
更新日期：2020-05-07 00:00:00
abstract：:Objective: The purpose of this study was to assess the association between extent of brachial plexus injury and shoulder abduction/external rotation outcomes after spinal accessory nerve (SAN) to suprascapular nerve (SSN) transfer.Methods: A systematic review of the literature was conducted according to PRISMA guideli...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.1080/02688697.2019.1639620
更新日期：2020-10-01 00:00:00
abstract：:We report a 10-year-old boy who presented with a subarachnoid haemorrhage from a ruptured hypoglossal artery aneurysm. The aneurysm was clipped via a transcondylar approach. The embryology, occurrence and the surgical approach to aneurysms at this site are discussed. ...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.1080/02688699646952
更新日期：1996-12-01 00:00:00
abstract：AIM:The aim of this study was to evaluate the adherence to current guidelines for the investigation of suspected subarachnoid haemorrhage and the prevalence and outcome of computed tomography (CT)-negative aneurysmal subarachnoid haemorrhage. DESIGN:A retrospective review in a single large tertiary referral centre. S...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.1080/02688697.2016.1265089
更新日期：2017-04-01 00:00:00
abstract：:The objective was to measure metabolic changes monitored by bedside microdialysis during impending and manifest hypoxia in traumatic brain injury. In 41 patients, a PtiO2-catheter (Licox; 1/min) was placed into non-lesioned frontal white matter together with a microdialysis catheter (CMA, hourly). Data were analysed f...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.1080/02688690310001601234
更新日期：2003-08-01 00:00:00
abstract：:Pial arteriovenous fistula (AVF) is a rare vascular lesion, with less than 120 reported cases in the English literatures (Hoh et al., Neurosurgery 2001;49(6):1351). The angio-architecture, clinical course and therapeutic options are all different from arteriovenous malformation (AVM), dural AVM or other intracranial v...
journal_title：British journal of neurosurgery
pub_type： 杂志文章,评审
doi：10.3109/02688697.2011.566382
更新日期：2011-10-01 00:00:00
abstract：:The endoscopic technique is increasingly being used for the resection of pituitary adenomas. Its efficacy and safety have been generally accepted, but its impact on the quality of life of the patients treated has not been previously addressed. Most of the studies assessing the quality of life after long-term cure of p...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.1080/02688690802220379
更新日期：2008-10-01 00:00:00
abstract：:Background: To analysis the role of gamma knife radiosurgery (GKRS) in treatment of the recurrent or residual World Health Organization (WHO) grade II and III meningiomas.Methods: Between 1995 and 2015, a total of 1163 meningioma patients were treated with GKRS at our single institute; 26 atypical and 6 anaplastic men...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.1080/02688697.2020.1726285
更新日期：2020-06-01 00:00:00
abstract：:We report the case of a young woman who developed brain swelling during an ultrasound-guided craniotomy for tumour. A contralateral acute extradural haematoma was identified with the ultrasound and removed. No cause for the extradural was found. ...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.3109/02688697.2010.550964
更新日期：2011-06-01 00:00:00
abstract：:Objective: Vaccination therapy using tumour antigen-loaded, autologous dendritic cells (DC) is a promising therapeutic approach alongside standard treatment for glioblastoma (GBM). However, reliable diagnostic criteria regarding therapy monitoring are not established. Here, we analysed the impact of additional 18F-flu...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.1080/02688697.2019.1639615
更新日期：2019-08-13 00:00:00
abstract：:A retrospective study was performed to evaluate the rate of infection in free and osteoplastic bone flaps after craniotomy. Two hundred and two craniotomies were performed in 98 cases of tumour, 35 cases of trauma and 69 cases of vascular disease. The overall incidence of infection was 6.4% (13 cases). The infectious ...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.3109/02688699008993798
更新日期：1990-01-01 00:00:00
abstract：:OCT4 expresses variably in primary intracranial germinomas. In this study, we tested our hypothesis that such variation of OCT4 is predictive of outcome in primary intracranial germinomas. Thirty-one histologically identified CNS germinoma patients were enrolled in our study. We collected medical data, immunohistochem...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.3109/02688697.2011.605483
更新日期：2012-04-01 00:00:00
abstract：:In this study occipital lobectomies were carried out on 12 foetal lambs on about the 100th day of gestation. Three lambs were born alive and had computed tomographic (CT) scans performed on the 13th or 18th day of life. One lamb was found to have hydrocephalus due to ventriculitis. All three lambs had low attenuation ...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.3109/02688698709023777
更新日期：1987-01-01 00:00:00
abstract：:Spontaneous intracranial hypotension (SIH) is an uncommon clinical entity that is often diagnosed after a delay, or it is misdiagnosed due to the variety of clinical presentations and the associated radiological findings. We present here a case of SIH associated with chronic subdural haematoma (SDH) and subarachnoid h...
journal_title：British journal of neurosurgery
pub_type： 杂志文章
doi：10.1080/02688690701790597
更新日期：2008-04-01 00:00:00
