Lactic acid, neuron-specific enolase, and blood-brain barrier index after a severe traumatic brain injury: a prospective study.

Abstract:

OBJECTIVE:To explore the clinical significance of dynamic monitoring of cerebrospinal fluid (CSF) and serum Lactic acid(Lac), neuron-specific enolase (NSE), and the blood-brain barrier (BBB) index in evaluating the condition and prognosis after a severe traumatic brain injury (TBI). METHODS:A total of 52 severe TBI patients admitted to the Department of Neurosurgery within 24 hours after injury were dynamically monitored. CSF and serum samples were collected on the 1st, 3rd, and 7th day after a severe TBI to monitor the changes in Lac, NSE, and the BBB index. Intracranial pressure (ICP), Glasgow coma scale (GCS), and 6-month Glasgow outcome scale-extended (GOS-E) were tested. According to the results of GOS-E, the patients were divided into two groups (i.e. the poor prognosis group and good prognosis group). Statistical analysis was conducted to investigate the clinical significance of dynamic monitoring of CSF and serum Lac, NSE, and BBB index after a severe TBI. RESULTS:After a severe TBI, the levels of Lac, NSE, and BBB in CSF and serum were significantly higher than those in the normal range. Lac, NSE, and the BBB index did not correlate with ICP (except serum Lac) but had correlations with GCS and post-injury 6 months post-injury (except serum Lac). Moreover, the correlations between Lac, NSE, and BBB index were statistically significant (p < 0.05): CSF Lac and CSF NSE; CSF Lac and serum NSE; Lac and BBB index of CSF; Lac and BBB index of CSF; NSE and CSE of serum; CSF NSE and BBB index; and serum NSE and BBB index. Additionally, serum NSE is correlated with NSE in CSF (p < 0.05). CONCLUSION:After a severe TBI, dynamic monitoring of CSF and serum Lac, NSE, and BBB index has the potential to assess the condition, predict the prognosis, and have clinical significance.

journal_name

Br J Neurosurg

authors

Lu W,Jiang C,Wang Z,Chen Y,Bai R,Yan G,Wang G,Ren H

doi

10.1080/02688697.2020.1823938

subject

Has Abstract

pub_date

2020-10-05 00:00:00

pages

1-5

eissn

0268-8697

issn

1360-046X

pub_type

杂志文章
  • Outcomes and quality of life assessment in patients undergoing endoscopic surgery for pituitary adenomas.

    abstract::The endoscopic technique is increasingly being used for the resection of pituitary adenomas. Its efficacy and safety have been generally accepted, but its impact on the quality of life of the patients treated has not been previously addressed. Most of the studies assessing the quality of life after long-term cure of p...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.1080/02688690802220379

    authors: Karabatsou K,O'Kelly C,Ganna A,Dehdashti AR,Gentili F

    更新日期:2008-10-01 00:00:00

  • Understanding the motivations, needs, and challenges faced by aspiring neurosurgeons in Africa: an E-survey.

    abstract:INTRODUCTION:Three million African patients need a neurosurgical consultation every year, but there are not enough neurosurgeons to meet this need. Efforts have been made to increase the neurosurgical capacity through the creation of training programs in Africa. Although these programs have been successful, there is st...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.1080/02688697.2020.1862053

    authors: Kanmounye US,Zolo Y,Tsopmene MRD,Nguembu S,Ndajiwo AB,Abdifatah K,Sichimba D,Sallah AY,Endalle G,Kaduyu R,Chege KK,Takoukam R,Hasheela T,Bankole NDA,Kabulo KDM,Tétinou F,Nitcheu IA,Ibe CS,Nyalundja AD,Djiofack D,T

    更新日期:2020-12-22 00:00:00

  • Failure of osseous conduction with cervical interbody BOP graft.

    abstract::We report three patients treated for cervical radiculopathy by anterior cervical discectomy and BOP grafting. Because of recurrent symptoms re-exploration was carried out 30 months later in the first case, 10 months in second and 8 months in the third case. At reoperation the grafts were disrupted into easily separabl...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.1080/02688699746717

    authors: Hafez RF,Crockard HA

    更新日期:1997-02-01 00:00:00

  • Is intra arterial nimodipine really beneficial in vasospasm following aneurysmal subarachnoid haemorrhage?

    abstract:UNLABELLED:Object/Background: Vasospasm is a common cause of mortality and morbidity following rupture of intracranial aneurysm. Hemodynamic therapy instituted in these patients in the past has been replaced by direct manipulation of the spastic vessels by angioplasty and intra-arterial infusion of vasodilators. Howeve...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3109/02688697.2016.1161172

    authors: Goel R,Aggarwal A,Salunke P,Kumar A,Chhabra R

    更新日期:2016-08-01 00:00:00

  • Contralateral lumbosacral plexopathy following lumbar microdiscectomy.

    abstract::We describe the unique case of a 51-year-old lady who developed a contralateral lumbosacral plexopathy two days after a lumbar microdiscectomy. This is the first report to date of this complication occurring following this procedure. We review the literature regarding lumbosacral plexopathy and discuss the evidence ba...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.1080/02688697.2018.1429568

    authors: Tulloch I,Ali R,Papadopoulos MC

    更新日期:2020-08-01 00:00:00

  • Effectiveness and outcomes of surgery for cerebral metastases.

    abstract:INTRODUCTION:The main treatment modalities for single brain metastases are whole brain radiotherapy (WBRT), surgery and stereotactic radiosurgery. Current guidelines recommend complete surgical excision for single cerebral metastases and two randomised controlled trials (RCT) have also found survival benefit of surgery...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3109/02688697.2013.771729

    authors: Lim CS,Grundy PL

    更新日期:2013-10-01 00:00:00

  • Subarachnoid haemorrhage in a child from an aneurysm of a persistent primitive hypoglossal artery.

    abstract::We report a 10-year-old boy who presented with a subarachnoid haemorrhage from a ruptured hypoglossal artery aneurysm. The aneurysm was clipped via a transcondylar approach. The embryology, occurrence and the surgical approach to aneurysms at this site are discussed. ...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.1080/02688699646952

    authors: Duffill J,Lang DA,Dwyer GN

    更新日期:1996-12-01 00:00:00

  • The influence of choice of therapy on quality of life in patients with neurogenic thoracic outlet syndrome.

    abstract:OBJECTIVES:We aimed to compare quality of life (QoL) after surgical decompression of the thoracic outlet versus non-operative therapy in patients with neurogenic thoracic outlet syndrome (N-TOS). DESIGN AND METHODS:We retrospectively identified 46 patients, diagnosed with N-TOS between 1999 and 2008. Twenty-four opera...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3109/02688697.2010.489656

    authors: Bosma J,Van Engeland MI,Leijdekkers VJ,Vahl AC,Wisselink W

    更新日期:2010-10-01 00:00:00

  • Stereotactic LINAC radiosurgery.

    abstract::A system of stereotactic radiosurgery using a linear accelerator is described and the experience with a variety of neurosurgical lesions including gliomas, acoustic neurinomas and arteriovenous malformations is recorded. The system is simple, inexpensive and effective and can be used with any CT scanner and linear acc...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3109/02688698909002808

    authors: Hitchcock E,Kitchen G,Dalton E,Pope B

    更新日期:1989-01-01 00:00:00

  • The shrinking vestibular schwannoma.

    abstract::We present a case of spontaneous 79% regression in the size of a vestibular schwannoma (VS). A 41-year-old lady with a large (36 mm) vestibular schwannoma underwent serial follow-up MRI scans which demonstrated the shrinkage over 9 years; the highest relative spontaneous regression recorded in the literature for vesti...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.1080/02688697.2019.1582749

    authors: Amoo M,Rawluk D,Mcconn-Walsh R,Javadpour M

    更新日期:2019-03-04 00:00:00

  • Irrigation can cause prolonged intracranial pressure elevations during endoscopic treatment of intraventricular haematomas.

    abstract:BACKGROUND:Irrigation may elevate the intracranial pressure (ICP) during neuroendoscopic procedures. It is unlikely that rinsing the ventricles during routine endoscopic ventriculostomy causes persistent neurological impairment or damage, but procedures such as the endoscopic evacuation of intraventricular haematomas (...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3109/02688697.2011.619596

    authors: Trnovec S,Halatsch ME,Putz M,Behnke-Mursch J,Mursch K

    更新日期:2012-04-01 00:00:00

  • A case report of the management of multiple metachronous haemangioblastomas in a patient with von Hippel - Lindau disease.

    abstract::Cerebellar haemangioblastomas commonly arise in patients with von Hippel - Lindau disease. We present the case of a 47-year-old male who has successfully undergone 10 separate procedures for symptomatic cerebellar haemangioblastomas. To our knowledge, this case is unique with respect to the frequency of symptomatic re...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.1080/02688690701552864

    authors: Newman S,Wasserberg J

    更新日期:2008-02-01 00:00:00

  • Bicoronal frontobasal approach with a limited, midline orbital bar osteotomy - a technical note.

    abstract::The frontobasal approach remains a workhorse for removing large olfactory groove meningiomas. Removal of the orbital bar in addition to standard bifrontal craniotomy allows for additional basal exposure, minimising brain retraction and allowing early and direct access to both the vascular supply and dural origin of th...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3109/02688697.2015.1071329

    authors: Patel K,Kolias AG,Kirollos RW

    更新日期:2016-01-01 00:00:00

  • Iatrogenic intracranial placement of nasopharyngeal airway after trauma.

    abstract::CT images of an 18-year-old woman who had sustained head trauma after a motor vehicle accident are presented demonstrating the iatrogenic intracranial placement of a nasopharyngeal airway. Treatment required a decompressive craniectomy, removal of the nasopharyngeal airway under direct vision, and duraplasty. The pati...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3109/02688697.2015.1133804

    authors: Swanson KI,Nickele CM,Kuo JS

    更新日期:2016-08-01 00:00:00

  • Concepts of neurosurgical management of chronic subdural haematoma: historical perspectives.

    abstract::The history of chronic subdural haematoma (CSH), spanning from its possibly earliest beginnings throughout the centuries until the early 1980s, was investigated within the context of four different epochs. In the 'era of uncertainty', successful trephination, the modem method of choice for the treatment of CSH, was de...

    journal_title:British journal of neurosurgery

    pub_type: 传,历史文章,杂志文章

    doi:10.1080/02688690410001660418

    authors: Weigel R,Krauss JK,Schmiedek P

    更新日期:2004-02-01 00:00:00

  • The extent of brachial plexus injury: an important factor in spinal accessory nerve to suprascapular nerve transfer outcomes.

    abstract::Objective: The purpose of this study was to assess the association between extent of brachial plexus injury and shoulder abduction/external rotation outcomes after spinal accessory nerve (SAN) to suprascapular nerve (SSN) transfer.Methods: A systematic review of the literature was conducted according to PRISMA guideli...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.1080/02688697.2019.1639620

    authors: Rezzadeh K,Donnelly M,Vieira D,Daar D,Shah A,Hacquebord J

    更新日期:2020-10-01 00:00:00

  • Anatomical landmarks for positioning the head in preparation for the transsphenoidal approach: the spheno-sellar point.

    abstract::The transnasal approach is the most utilized approach to the sellar region. This study was conducted to identify an anatomical landmark on the lateral surface of the head that corresponds to the midpoint of the sellar floor at the level of sphenoidal rostrum. This point, lined up with the nostril, simulates the surgic...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.1080/02688690802630056

    authors: Campero A,Socolovsky M,Torino R,Martins C,Yasuda A,Rhoton AL Jr

    更新日期:2009-06-01 00:00:00

  • Systemic inflammatory response syndrome and acute neurological disease.

    abstract::Systemic inflammatory response syndrome is a common clinical entity often presenting as a complication of neurological disease or trauma. Clear diagnostic criteria exist. Induced pathological mechanisms include both immunological and endothelial dysfunction, and coagulopathy, which may lead to multiple organ failure a...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1080/02688690120082378

    authors: Malham GM,Souter MJ

    更新日期:2001-10-01 00:00:00

  • Case report: Recurrent glossopharyngeal neuralgia after previous glossopharyngeal rhizotomy: Microvascular decompression with intra-operative neurophysiology.

    abstract::We present a case of recurrent vago-glossopharyngeal neuralgia after previous surgery, treated successfully with microvascular decompression using intra-operative neurophysiology monitoring. ...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3109/02688697.2015.1039486

    authors: Price SA,Davies O,Walsh P,Patel N

    更新日期:2015-01-01 00:00:00

  • Spontaneous subarachnoid haemorrhage due to acoustic neurinoma. Case report and review of the literature.

    abstract::Subarachnoid haemorrhage (SAH) of the posterior fossa in cases of acoustic neurinoma is very rare. The authors present the clinical, neuroradiological and histological findings of an acoustic neurinoma presenting with SAH. The literature regarding this subject is reviewed and the pathogenesis of haemorrhage from neuri...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章,评审

    doi:10.3109/02688690903506085

    authors: Gavra M,Thanos L,Pomoni M,Batakis N

    更新日期:2010-02-01 00:00:00

  • Posterior fossa ICP monitoring: a tale of two compartments.

    abstract::Aim: Measuring the intracranial pressure (ICP) of the infra-tentorial, posterior fossa compartment has long been avoided due to a lack of precedent and interpretability, as well as concern of damage to the underlying vital structures. In cases of posterior fossa insults however, the supra-tentorial compartment ICPs ca...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.1080/02688697.2020.1765974

    authors: Khan A,Borg N,Shenouda E

    更新日期:2020-05-15 00:00:00

  • The role of neuronavigation-guided functional MRI and diffusion tensor tractography along with cortical stimulation in patients with eloquent cortex lesions.

    abstract::OBJECTIVE. To effectively combine functional MRI (fMRI), diffusion tensor tractography (both guided by neuronavigation) along with cortical stimulation (CS) for surgery of eloquent cortex (EC) lesions. MATERIALS AND METHOds. Fifteen patients with lesions adjacent to the eloquent motor and sensory cortex were included....

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3109/02688697.2013.835370

    authors: Kumar A,Chandra PS,Sharma BS,Garg A,Rath GK,Bithal PK,Tripathi M

    更新日期:2014-04-01 00:00:00

  • Tumour cell dispersion by the ultrasonic aspirator during brain tumour resection.

    abstract::Ultrasonic aspirators are commonly used to resect brain tumours because they allow safe, rapid and accurate removal of diseased tissue. Since ultrasonic aspirators generate a spray of aerosolized irrigating fluid around the instrument tip, we questioned whether this spray might contain viable tumours cells that could ...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:

    authors: Preston JK,Masciopinto J,Salamat MS,Badie B

    更新日期:1999-10-01 00:00:00

  • Simultaneous presentation of meningiomas with other intracranial tumours.

    abstract::Fifteen patients with simultaneous presentation of meningiomas with other intracranial tumours are reviewed. The associated tumours included a brain metastasis in six cases, glioma in three, pituitary adenoma in two, craniopharyngioma in one,acoustic schwannoma in two and brain lymphoma in one. A correct preoperative ...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.1080/02688690500305548

    authors: Maiuri F,Cappabianca P,Iaconetta G,Esposito F,Messina A

    更新日期:2005-08-01 00:00:00

  • Subtotal petrosectomy in the treatment of cerebrospinal fluid fistulae of the lateral skull base.

    abstract::Cerebrospinal fluid (CSF) fistulae almost invariably lead to meningitis, even in the absence of other clinically obvious sequelae of the fistula such as a CSF fluid leak. The only effective means of reducing the risk of meningitis is surgical closure of the fistula. If surgery is to be recommended to patients with CSF...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.1080/02688699745646

    authors: Hamilton JW,Foy PM,Lesser TH

    更新日期:1997-12-01 00:00:00

  • Clinical and methodological confounders in assessing the cerebellar cognitive affective syndrome in adult patients with posterior fossa tumours.

    abstract::The cerebellar cognitive affective syndrome (CCAS) was first described by Schmahmann and Sherman as a constellation of symptoms including dysexecutive syndrome, spatial cognitive deficit, linguistic deficits and behavioural abnormalities in patients with a lesion in the cerebellum with otherwise normal brain. Neurosur...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章,评审

    doi:10.3109/02688697.2014.920487

    authors: Omar D,Ryan T,Carson A,Bak TH,Torrens L,Whittle I

    更新日期:2014-12-01 00:00:00

  • Pain and functional outcomes following vertebroplasty for vertebral compression fractures - A tertiary centre experience.

    abstract:OBJECTIVES:There is a dearth of comparative outcome data on vertebroplasty for the treatment of vertebral compression fractures (VCF) according to vertebral level, the number of levels and aetiology. The aim of this study was to investigate the improvement of pain and function following vertebroplasty for a heterogeneo...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3109/02688697.2015.1096901

    authors: Mukherjee S,Yeh J,Ellamushi H

    更新日期:2016-01-01 00:00:00

  • The impact of epilepsy on the quality of life of patients with meningioma: A systematic review.

    abstract::Quality of life (QoL) is regarded as an important outcome measure in meningioma, and studies have investigated the role of various clinical and demographic factors. Epilepsy is known to impair quality of life but the impact of epilepsy on quality of life in a meningioma population is not well defined. The aim of this ...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章,评审

    doi:10.3109/02688697.2015.1080215

    authors: Tanti MJ,Marson AG,Chavredakis E,Jenkinson MD

    更新日期:2016-01-01 00:00:00

  • Intrasellar pituitary mucocele: diagnostic dilemma.

    abstract::Isolated intrasellar pituitary mucocele following transsphenoidal sinus surgery is extremely rare. The clinical features resemble a pituitary tumor, therefore careful radiological interpretation is crucial to reach the correct diagnosis. We report a case of intrasellar mucocele who had transsphenoidal sinus surgery pe...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3109/02688697.2013.817535

    authors: Tang IP,Chai CK,Kumar G,Prepageran N,Waran V

    更新日期:2014-06-01 00:00:00

  • Delayed diagnosis, due to the associated radiological abnormalities, of spontaneous intracranial hypotension caused by cerebrospinal fluid leakage at C1-2.

    abstract::Spontaneous intracranial hypotension (SIH) is an uncommon clinical entity that is often diagnosed after a delay, or it is misdiagnosed due to the variety of clinical presentations and the associated radiological findings. We present here a case of SIH associated with chronic subdural haematoma (SDH) and subarachnoid h...

    journal_title:British journal of neurosurgery

    pub_type: 杂志文章

    doi:10.1080/02688690701790597

    authors: Joo WI,Lee KJ,Rha HK,Park HK,Chough JK

    更新日期:2008-04-01 00:00:00