Long-term outcome in patients with central neurocytoma following stereotactic biopsy and radiation therapy.

Abstract:

:Total excision is usually the recommended treatment for central neurocytomas. The role of radiation therapy in their management is controversial, and is usually reserved for partially resected or recurrent tumours. Long-term outcome was studied in patients with central neurocytoma who were treated with radiation therapy. By retrospective chart review, eight patients with intraventricular tumours, who had undergone radiation therapy following stereotactic biopsy, were identified. The diagnosis of neurocytoma was confirmed based on positive immunostaining with synaptophysin. Clinical and radiological follow-up was obtained. Of eight patients, one died 5 years after treatment from shunt dysfunction and 1 had disseminated intracranial disease 15 months after treatment. Six patients were symptom-free at a mean follow-up period of 78 months and had good local control as demonstrated by CT. Since this tumour can be confused with an oligodendroglioma or an ependymoma on routine histopathology (as happened in seven of our cases); immunohistochemical studies with synaptophysin should be routinely performed for intraventricular glial tumours. Our study supports the beneficial effect of radiation therapy in the management of these tumours.

journal_name

Br J Neurosurg

authors

Kulkarni V,Rajshekhar V,Haran RP,Chandi SM

doi

10.1080/02688690220131714

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

126-32

issue

2

eissn

0268-8697

issn

1360-046X

journal_volume

16

pub_type

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