Abstract:
:Objective: Vaccination therapy using tumour antigen-loaded, autologous dendritic cells (DC) is a promising therapeutic approach alongside standard treatment for glioblastoma (GBM). However, reliable diagnostic criteria regarding therapy monitoring are not established. Here, we analysed the impact of additional 18F-fluoroethyl-tyrosine positron emission tomography (18F-FET PET) imaging following DC vaccination therapy. Methods: We analysed data of GBM patients who received DC vaccination therapy. Following MRI diagnosis of tumour recurrence, additional static and dynamic 18F-FET PET imaging was performed. Vaccination was performed five times by intradermal injections, either weekly between concomitant radio/-chemotherapy and intermittent chemotherapy or after tumour recurrence, before re-radiation therapy. MRI and 18F-FET PET results were compared and correlated with clinical data. Results: Between 2003 and 2016, 5 patients were identified who received DC vaccination and 18F-FET PET imaging (1 female/4 males; mean age: 44 ± 14 y). 3/5 patients showed congruent results of tumour progression. In three patients 18F-FET PET indicated treatment related changes, which was in contrast to MRI findings that indicated tumour progression. In these patients 18F-FET PET results could be confirmed by either neuropathological diagnosis or according to the RANO criteria Conclusions: Despite the small patients number our results indicate an additional impact of 18F-FET PET for monitoring outcome following vaccination therapy.
journal_name
Br J Neurosurgjournal_title
British journal of neurosurgeryauthors
Kristin Schmitz A,Sorg RV,Stoffels G,Grauer OM,Galldiks N,Steiger HJ,Kamp MA,Langen KJ,Sabel M,Rapp Mdoi
10.1080/02688697.2019.1639615subject
Has Abstractpub_date
2019-08-13 00:00:00pages
1-7eissn
0268-8697issn
1360-046Xpub_type
杂志文章abstract::Background: Posterior fossa decompression both with and without duraplasty are accepted treatments for symptomatic adult patients with Chiari Malformations Type 1 (CM-1). There is still debate of the superiority of one technique over the other. The purpose of this study was to determine the clinical and craniometrical...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2019.1617407
更新日期:2019-10-01 00:00:00
abstract::Primary melanocytic tumors of the central nervous system (CNS) are rare lesions, but primary sellar tumors are rarer. Only 10 cases have been reported, and they are often misdiagnosed as pituitary macroadenoma. We report the case of a 54-year-old Chinese man who developed progressive bitemporal hemianopsia and visual ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章,评审
doi:10.3109/02688697.2014.967752
更新日期:2015-04-01 00:00:00
abstract::The transnasal approach is the most utilized approach to the sellar region. This study was conducted to identify an anatomical landmark on the lateral surface of the head that corresponds to the midpoint of the sellar floor at the level of sphenoidal rostrum. This point, lined up with the nostril, simulates the surgic...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690802630056
更新日期:2009-06-01 00:00:00
abstract::Purpose: The purpose of this study was to validate the cauda scale (TCS) in an external population. TCS was proposed as a tool to be used to predict the likelihood of cauda equina compression.Methods: We analysed the presenting condition of consecutive patients attending the emergency department undergoing a magnetic ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2020.1754337
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Maintenance of on-call referrals databases is on the rise in neurosurgical units across the UK and helps provide data to estimate workload. We hypothesize that these databases underestimate the workload and propose the use of the number of telephone calls to the on-call registrar as an easily obtainable and ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2012.743966
更新日期:2013-06-01 00:00:00
abstract::Tonsillar herniation is a rare and seldom reported complication after lumboperitoneal (LP) shunting. There have been only few reports that have presented possible options for treatment with varying degrees of success. In this report, we describe a rare case of tonsillar herniation after LP shunting and review related ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2018.1538481
更新日期:2018-12-06 00:00:00
abstract::Background: Few data are available on the risk factors involved in nosocomial meningitis from multi-drug-resistant Gram-negative bacteria (MDR-GNB). Our aim was to identify the risk factors of prognosis for MDR-GNB nosocomial meningitis.Methods: Retrospective study of patients undergoing neurosurgery and with positive...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2019.1710819
更新日期:2020-06-01 00:00:00
abstract::The authors report the rare and first documented case of intracranial collision tumour occurrence in a previously evacuated intracerebral haematoma site. Surgery trauma could predispose to collision tumour occurrence. Research efforts should try to reveal the possible pathogenesis of this condition. ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2012.697220
更新日期:2012-12-01 00:00:00
abstract::Several studies have demonstrated an association between arterial hypertension (AH) and an increased morbidity and mortality from both cardiovascular diseases and stroke (including subarachnoid haemorrhage, SAH). Among the functional disturbances implicated in hypertension much interest has been focused on the calcium...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688699108998477
更新日期:1991-01-01 00:00:00
abstract::Few data exist regarding the management of severe head injury in non-neurosurgical centres within the UK. We aimed to discover the number of intensive care units admitting head injury patients, the number of patients admitted annually, and the monitoring and treatment methods followed. Questionnaires were sent to the ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688699845438
更新日期:1998-02-01 00:00:00
abstract:INTRODUCTION:Surgical-site infection (SSI) is associated with significant morbidity and mortality. Public Health England or PHE has published guidance on its surveillance, which is now mandatory in some specialities. We review how appropriate their programme is for monitoring SSI in cranial neurosurgery [CN]. METHOD:S...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2015.1071321
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To explore the clinical significance of dynamic monitoring of cerebrospinal fluid (CSF) and serum Lactic acid(Lac), neuron-specific enolase (NSE), and the blood-brain barrier (BBB) index in evaluating the condition and prognosis after a severe traumatic brain injury (TBI). METHODS:A total of 52 severe TBI pa...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2020.1823938
更新日期:2020-10-05 00:00:00
abstract::Low-grade (WHO level I) meningiomas are slow-growing, benign tumours typically presenting with unspecific symptoms (e.g. headache), seizures, cranial nerve compression and neuropsychological symptoms determined by location and size of the lesion. Haemorrhagic onset and sequelae are rare, and have been described infreq...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690500208734
更新日期:2005-06-01 00:00:00
abstract:INTRODUCTION:There is a high rate of IDH1/2 mutations in low grade gliomas and in high grade gliomas deriving from them. IDH analysis of gliomas is a novel method of classification and an independent prognostic marker. We compared antibody and sequencing methods for the detection of IDH mutations. METHOD:88 samples fr...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2013.771139
更新日期:2013-08-01 00:00:00
abstract::Two case reports illustrate a long vascular pedicle cranial bone flap. A split or full thickness skull bone flap is based on the pericranium layer. The temporalis muscle with its overlying fascial layers and vascular pedicles form the base of this flap and assure its adequate vascularization. The technique and its use...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::Nosocomial infections, pneumonia in particular, are well-known complications of traumatic brain injury (TBI), which are associated with a worse neurological outcome. This review aims to explore the role of vagus nerve activity in immunomodulation as a causative factor. A MEDLINE search revealed numerous reports publis...
journal_title:British journal of neurosurgery
pub_type: 杂志文章,评审
doi:10.3109/02688697.2013.835373
更新日期:2014-04-01 00:00:00
abstract:UNLABELLED:Object/Background: Vasospasm is a common cause of mortality and morbidity following rupture of intracranial aneurysm. Hemodynamic therapy instituted in these patients in the past has been replaced by direct manipulation of the spastic vessels by angioplasty and intra-arterial infusion of vasodilators. Howeve...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2016.1161172
更新日期:2016-08-01 00:00:00
abstract::Acute subdural haematoma (SDH) as a result of aneurysmal rupture is a rare event. We report a tentorium cerebelli SDH, secondary to a ruptured aneurysm which we believe is unique in the literature. This report also gives further support to the theory that a sentinel bleed causes inflammation and adhesion between the a...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/026886900417432
更新日期:2000-08-01 00:00:00
abstract::Lymphocytic and granulocytic hypophysitis are rare pituitary masses. A series of five dealt with at a single centre is presented and discussed. Retrospective analysis of pathology records revealed the cases. Of pituitary mass lesions dealt with in this centre, 0.8% have the diagnosis. Five females presented, one pregn...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690120057664
更新日期:2001-06-01 00:00:00
abstract::Despite advances in imaging of the brain, an accurate diagnosis of brain lesions requires tissue sampling and histological verification. A series of CT-directed procedures has been performed in 300 patients with deep sited, multiple, diffuse, extensive, small or inflammatory lesions, brain stem haematomas and tumours ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688698909002810
更新日期:1989-01-01 00:00:00
abstract::Spontaneous intracranial hypotension (SIH) is an uncommon clinical entity that is often diagnosed after a delay, or it is misdiagnosed due to the variety of clinical presentations and the associated radiological findings. We present here a case of SIH associated with chronic subdural haematoma (SDH) and subarachnoid h...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688690701790597
更新日期:2008-04-01 00:00:00
abstract::Cortical thermal clearance was used during surgery for clipping of a giant middle cerebral artery (MCA) aneurysm. During prolonged continuous proximal MCA occlusion thermal clearance remained normal, indicating sufficient collateral blood supply. Postoperatively the patient had no neurological deficit. This monitoring...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688699308995097
更新日期:1993-01-01 00:00:00
abstract::Several studies have shown that thalamic deep brain stimulation (DBS) reduces tremor and improves hand performance in patients with multiple sclerosis (MS). The purpose of this paper is to describe the cost implications of DBS in MS patients and to highlight postoperative medical requirements that can be associated wi...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:
更新日期:2003-02-01 00:00:00
abstract::A 33-year-old man presented with a history of fits and on initial investigation was suspected of having a left frontal parafalcine meningioma. Initial surgical procedure to excise the lesion had to be abandoned owing to the extreme vascularity of the lesion. Histology revealed it to be a haemangioendothelioma. At a se...
journal_title:British journal of neurosurgery
pub_type: 杂志文章,评审
doi:10.1080/02688699943123
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:The optic nerve is an unusual site of schwannoma as it lacks Schwannoma cells on it. We report a primary optic sheath schwannoma and to review the literature. CASE REPORT:A 29-year old female presented with progressive painless non-pulsatile proptosis. Ocular examination revealed only axial proptosis. Imagi...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2020.1869181
更新日期:2021-01-08 00:00:00
abstract:OBJECTIVES:Patients with moyamoya disease (MMD) very rarely develop both cerebral ischaemia and haemorrhage. The aim of this study was to clarify the clinical and radiographic features of MMD in patients who presented with both ischaemia and haemorrhage, compared with MMD patients who presented with one or the other. ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.3109/02688697.2012.717983
更新日期:2013-04-01 00:00:00
abstract::Two cases with a unique association of Rathke's cleft cysts and a growth hormone-secreting pituitary adenoma in the same tumour tissue are reported. The embryological pathogenesis, diagnostic evaluation and treatment of these lesions are discussed. ...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688699550041755
更新日期:1995-01-01 00:00:00
abstract::We report our experience with five lesions exclusively involving the entire cavernous sinus in which an essentially extradural surgical approach was used. There were two cases of cavernous haemangioma, two cases of meningioma and one case of fungal granuloma. The dural cover of the superior orbital fissure, and mandib...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688699746483
更新日期:1997-04-01 00:00:00
abstract::Sellar melanocytomas represent a small subgroup of primary melanocytic tumors arising from leptomeningeal melanocytes. They are benign, slow-growing tumors with a high risk of recurrence. We report two cases of sellar melanocytoma treated at the same institute. A 35-year-old woman presented with amenorrhea and an intr...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688697.2019.1667485
更新日期:2019-09-20 00:00:00
abstract::We have reviewed the records of 53 patients with visual impairment secondary to pituitary macroadenomas and studied the visual outcome after surgery. After transsphenoidal procedures visual field defects improved in 89% of the patients and visual acuity improved in 82%. There were 13 cases of acute symptomatic intratu...
journal_title:British journal of neurosurgery
pub_type: 杂志文章
doi:10.1080/02688699550041485
更新日期:1995-04-01 00:00:00