Abstract:
:NAC (nascent polypeptide associated complex) is a heterodimer consisting of an α and a β subunit. skNAC (skeletal and heart muscle-specific form of αNAC) is a variant of αNAC, which is induced in muscle differentiation and regeneration. We show here that skNAC expression is regulated by p38 MAPK, which plays a crucial role in myogenesis. Furthermore, inhibition of skNAC expression in myoblasts via specific siRNAs might lead to disturbed incorporation of myosin heavy chain (MyHC) into sarcomeres, however, it has no inhibitory effect on absolute MyHC protein levels. Taken together, our data suggest that skNAC regulates specific aspects of myogenesis.
journal_name
Eur J Cell Bioljournal_title
European journal of cell biologyauthors
Berger F,Berkholz J,Breustedt T,Ploen D,Munz Bdoi
10.1016/j.ejcb.2011.10.004subject
Has Abstractpub_date
2012-02-01 00:00:00pages
150-5issue
2eissn
0171-9335issn
1618-1298pii
S0171-9335(11)00212-3journal_volume
91pub_type
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