Abstract:
:In the yeast Saccharomyces cerevisiae, meiosis and spore formation require the induction of sporulation-specific genes. Two genes are thought to activate the sporulation program: IME1 and IME2 (inducer of meiosis). Both genes are induced upon entry into meiosis, and IME1 is required for IME2 expression. We report here that IME1 is essential for expression of four sporulation-specific genes. In contrast, IME2 is not absolutely essential for expression of the sporulation-specific genes, but contributes to their rapid induction. Expression of IME2 from a heterologous promoter permits the expression of these sporulation-specific genes, meiotic recombination, and spore formation in the absence of IME1. We propose that the IME1 and IME2 products can each activate sporulation-specific genes independently. In addition, the IME1 product stimulates sporulation-specific gene expression indirectly through activation of IME2 expression.
journal_name
Mol Cell Bioljournal_title
Molecular and cellular biologyauthors
Mitchell AP,Driscoll SE,Smith HEdoi
10.1128/mcb.10.5.2104subject
Has Abstractpub_date
1990-05-01 00:00:00pages
2104-10issue
5eissn
0270-7306issn
1098-5549journal_volume
10pub_type
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