Abstract:
AIMS:Early clinical trials suggest that blood-derived stem/progenitor cells (including peripheral blood-derived stem cells and circulating progenitor cells) may have a positive impact on patients with ischaemic heart disease (IHD). The therapeutic effects of these cells remain unclear, considering the inconsistent results of several clinical trials. The objective of this meta-analysis was to evaluate the effects of autologous blood-derived stem/progenitor cells on improvement of cardiac functional parameters on the basis of a synthesis of the data generated by randomised controlled clinical trials (RCTs) of patients with IHD. METHODS:Randomised controlled clinical trials were identified in the MEDLINE, the Cochrane Central Register of Controlled Trials, EBSCO, EMBASE, reviews and reference lists of relevant articles. All searching was completed on 12 January 2011. Weighted mean difference was calculated for changes in left ventricular ejection fraction (LVEF), left ventricular end-diastolic and end-systolic volumes (LVEDV and LVESV) using a fixed effects model. RESULTS:Of the 1587 citations identified in the literature search, six RCTs were finally analysed. Compared with controls, blood-derived stem/progenitor cells infusion was safe and improved LVEF by 3.72% (95% CI: 1.98-5.46%; p < 0.0001). However, no significant improvement in LVEDV and LVESV at follow-up was observed. CONCLUSIONS:Available evidence showed moderate improvements over conventional therapy in LVEF of blood-derived stem/progenitor cells transplantation in patients with IHD, and supports further RCTs with higher quality.
journal_name
Int J Clin Practjournal_title
International journal of clinical practiceauthors
Wen Y,Meng L,Ding Y,Ouyang Jdoi
10.1111/j.1742-1241.2011.02715.xsubject
Has Abstractpub_date
2011-08-01 00:00:00pages
858-65issue
8eissn
1368-5031issn
1742-1241journal_volume
65pub_type
杂志文章,meta分析,评审abstract::In this prospective qualitative study over 12 months, we evaluated the educational and clinical effectiveness of a new final year undergraduate programme in a London medical school (Guy's, King's and St Thomas'). A stratified sample of 17/360 final year students were interviewed four times, and the content was assesse...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1742-1241.2005.00438.x
更新日期:2005-03-01 00:00:00
abstract::This double-blind, randomised placebo-controlled, multicentre study evaluated the efficacy, tolerability and safety of 12 weeks' treatment with controlled release darifenacin 15 mg once daily (qd), in 445 patients with overactive bladder (OAB). The primary endpoint was warning time (time from first sensation of urgenc...
journal_title:International journal of clinical practice
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1368-5031.2005.00770.x
更新日期:2006-01-01 00:00:00
abstract:AIMS:Stress hyperglycaemia during hospitalisation may be the first sign of diabetes mellitus (DM). Most hospitals routinely measure blood glucose, which may enable early diagnosis. This study measured the prevalence of hyperglycaemia in hospitalised adults with no history of diabetes, and whether the discharge summary ...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.12690
更新日期:2015-11-01 00:00:00
abstract:AIM:To raise awareness on nocturia disease burden and to provide simplified aetiologic evaluation and related treatment pathways. METHODS:A multidisciplinary group of nocturia experts developed practical advice and recommendations based on the best available evidence supplemented by their own experiences. RESULTS:Noc...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:10.1111/ijcp.13027
更新日期:2017-11-01 00:00:00
abstract:INTRODUCTION:Peripartum cardiomyopathy (PPCM) is an uncommon form of congestive heart failure, afflicting obstetric patients around the time of delivery. The epidemiology of PPCM is infrequently reported. To the best of our knowledge, there has been no report from Asia. OBJECTIVE:To define the prevalence, presentation...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1742-1241.2007.01449.x
更新日期:2009-05-01 00:00:00
abstract::Erectile Dysfunction (ED) is common in men with diabetes. Diabetic men are three times as likely to develop ED as non-diabetic men. The cause is multifactorial, but most commonly reflects endothelial dysfunction and autonomic neuropathy. Diabetes and vascular disease often coexist and ED may be a marker for silent occ...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:10.1111/j.1368-5031.2004.00180.x
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND:Elevated levels of blood lipids are considered a major modifiable risk factor for the development of cardiovascular diseases. The optimal management of dyslipidaemia remains inadequate worldwide. Accordingly, there is an increasing need to evaluate the basis that health care providers are using to control dy...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.13784
更新日期:2020-10-23 00:00:00
abstract:BACKGROUND AND AIMS:The use of herbs and dietary supplements (HDS) alone or concomitantly with medications can potentially increase the risk of adverse events experienced by the patients. This review aims to evaluate the documented HDS-drug interactions and contraindications. METHODS:A structured literature review was...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:10.1111/j.1742-1241.2012.03008.x
更新日期:2012-11-01 00:00:00
abstract:AIMS:Although many elderly individuals suffer from type 2 diabetes, the effectiveness of cardioprotective drugs in primary prevention of cardiovascular events in clinical practice in this population has rarely been evaluated. We aimed to assess the effectiveness of, (i) angiotensin converting enzyme inhibitors or angio...
journal_title:International journal of clinical practice
pub_type: 杂志文章,多中心研究
doi:10.1111/ijcp.12503
更新日期:2015-03-01 00:00:00
abstract::Asthma treatment is suboptimal in many patients, with impacts on morbidity and mortality, healthcare resource utilisation and patients' quality of life. The reasons for this include the inherent variability of asthma and the unpredictability of exacerbations, which can range from mild to fatal. In addition, asthma can...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:10.1111/j.1368-5031.2004.00182.x
更新日期:2004-06-01 00:00:00
abstract:AIMS:To evaluate in a real-world setting the effectiveness of exenatide once-weekly (ExQW) in patients with T2D and to determine predictors of glycaemic and weight response to this drug at 6 months. METHODS:Observational, retrospective, multicenter study in adult patients with T2D and BMI ≥30 kg/m2 from 4 tertiary Spa...
journal_title:International journal of clinical practice
pub_type: 杂志文章,多中心研究
doi:10.1111/ijcp.13055
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVES:A significant proportion of COVID-19 patients may have cardiac involvement including arrhythmias. Although arrhythmia characterization and possible predictors were previously reported, there are conflicting data regarding the exact prevalence of arrhythmias. Clinically applicable algorithms to classify COVID...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.13788
更新日期:2020-10-30 00:00:00
abstract:BACKGROUND:'Do Not Attempt Cardiopulmonary Resuscitation' (DNACPR) orders are made frequently for older people in hospital. Sensitive anticipatory discussion is encouraged where possible, but usually this does not happen, despite the evidence suggesting that many older patients would like to be involved in such decisio...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.12067
更新日期:2013-04-01 00:00:00
abstract::Paliperidone, the 9-hydroxy metabolite of risperidone, was approved on 20 December, 2006 by the US Food and Drug Administration for the treatment of schizophrenia. It is also being tested for the treatment of bipolar mania. An on-line query of http://www.pubmed.gov and http://www.clinicaltrials.gov for 'paliperidone' ...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:10.1111/j.1742-1241.2007.01321.x
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVES:This study evaluates the effectiveness, safety and costs of switching to a rilpivirine/emtricitabine/tenofovir disoproxil fumarate (RPV/FTC/TDF) regimen in treatment-experienced HIV-1-infected patients with sustained virological suppression. METHODS:Observational, prospective study. Study population include...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.12968
更新日期:2017-08-01 00:00:00
abstract::Over the past years, there has been an explosive increase in the prevalence of type 2 diabetes (T2DM) and this is expected to continue, entailing associated morbidity and mortality. An increasing number of studies explore the different ways T2DM could be prevented. On-going lifestyle modifications need to be addressed...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:10.1111/j.1368-5031.2006.00929.x
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:Asthma diagnosis is based on the presence of symptoms and the demonstration of airflow variability. Airway inflammation measured by fractional exhaled nitric oxide, measured at a flow rate of 50 ml/s (FE(NO50)) remains a controversial diagnostic tool. AIM:To assess the ability of FE(NO50) to identify bronch...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1742-1241.2011.02840.x
更新日期:2012-02-01 00:00:00
abstract:AIMS:Investigate if angiotensin II receptor blocker (ARB) decreases risk of upper gastrointestinal bleeding (UGIB) in hypertensive patients with chronic kidney disease (CKD) not on dialysis. METHODS:All hypertensive patients with CKD not on dialysis in outpatient department of China Medical University Hospital from 20...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.12589
更新日期:2015-07-01 00:00:00
abstract::Biochemical test abnormality can indicate chronic alcohol abuse with good clinical sensitivity and specificity. Serum gamma glutamyltransferase and carbohydrate-deficient transferrin are the tests most frequently abnormal. ...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:
更新日期:1999-03-01 00:00:00
abstract:AIMS:We aimed to assess the prevalence, components and evolution of polypharmacy and to evaluate risk factors associated with polypharmacy. METHODS:A retrospective dynamic cohort study was performed, using a primary healthcare database comprising Flemish community-dwelling adults aged ≥40 years between 2011 and 2015. ...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.13942
更新日期:2020-12-19 00:00:00
abstract::Tobacco dependence remains the major preventable cause of early mortality and morbidity in the developed world. The primary reinforcer of the dependence is the nicotine present in tobacco smoke and, for many smokers, successful treatment depends upon breaking this dependence. Until recently, the only specific pharmaco...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Plasminogen Activator Inhibitor 1 (PAI-1) is a prothrombotic adipokine involved in the coagulation cascade and fibrinolysis that associated with proinflammatory adipokines may increase the risk related to obesity. Anthropometric measures are commonly used in clinical practice and, currently, neck circumferen...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/ijcp.12041
更新日期:2013-03-01 00:00:00
abstract:AIM:We analysed the effectiveness and safety of outpatient parenteral antibiotic therapy (OPAT) in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in patients admitted to home hospitalisation units (HHU). METHODS:Retrospective multicentre study of patients with AECOPD included in the Spanish OPAT ...
journal_title:International journal of clinical practice
pub_type: 杂志文章,多中心研究
doi:10.1111/ijcp.13022
更新日期:2017-12-01 00:00:00
abstract::Calcium dobesilate (Doxium) is used in the treatment of diabetic retinopathy. Clinical studies show a slowdown of the progression of the disease after long-term oral treatment. The main action of the drug is related to a reduction of microvascular permeability as measured by different parameters and methods (vitreous ...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:The high prevalence of both hypovitaminosis D and type 2 diabetes (T2DM) in the Asian community is well recognised, but the impact of diabetes on vitamin D status and vice versa, has not been well reported. AIMS:To determine the prevalence of hypovitaminosis D in Asian patients with T2DM and its impact on g...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1742-1241.2009.02221.x
更新日期:2010-02-01 00:00:00
abstract::Aberrations in the cell cycle regulators are common features of many tumours and several have been shown to have prognostic significant in colorectal cancer. The expression patterns of cyclins D1 and E as well as cyclin-dependent kinase (CDK) inhibitors p21waf1/cip1 and p27kip1 and their interrelationship with other c...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1742-1241.2006.01105.x
更新日期:2008-11-01 00:00:00
abstract::A drug utilisation review was carried out in the medical outpatient department of the Manipal teaching hospital, a tertiary care hospital in Pokhara, western Nepal, to determine the prescribing frequency of commonly used drugs. An attempt was made to relate prescription data to age and sex of the patients. A total of ...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:
更新日期:2002-09-01 00:00:00
abstract:BACKGROUND:The decision on whether or not to treat a first seizure is dependent on several medical and non-medical factors. AIMS:In this review, we have summarised the important aspects that determine the advantages and disadvantages of treating a first seizure. We have looked at evidence from randomised controlled tr...
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:10.1111/j.1742-1241.2008.01896.x
更新日期:2008-12-01 00:00:00
abstract::Marijuana is the most commonly used illicit drug while its abuse and dependence has an increasing prevalence among the young population. Marijuana smoking affects the circulatory system triggering various cardiovascular events. Of note, recent case reports indicate a possible association with atrial fibrillation (AF)....
journal_title:International journal of clinical practice
pub_type: 杂志文章,评审
doi:10.1111/j.1742-1241.2007.01505.x
更新日期:2008-02-01 00:00:00
abstract::The effects of diltiazem treatment on symptoms of chronic anal fissures and their long-term outcome were investigated. One hundred and twelve patients were supplied with 6-week course of 2% diltiazem cream for twice-daily topical application. The medical notes and extended follow-up by telephone for 112 patients were ...
journal_title:International journal of clinical practice
pub_type: 杂志文章
doi:10.1111/j.1742-1241.2006.00895.x
更新日期:2006-11-01 00:00:00