Abstract：
:The improvement of H2 production capabilities of hydrogen (H2)-producing microorganisms is a challenging issue. Microorganisms have evolved for fast growth and substrate utilization rather than H2 production. To develop good H2-producing biocatalysts, many studies have focused on the redirection and/or reconstruction of cellular metabolisms. These studies included the elimination of enzymes and carbon pathways interfering or competing with H2 production, the incorporation of non-native metabolic pathways leading to H2 production, the utilization of various carbon substrates, the rectification of H2-producting enzymes (nitrogenase and hydrogenase) and photophosphorylation systems, and in silico pathway flux analysis, among others. Owing to these studies, significant improvements in the yield and rate of H2 production, and in the stability of H2 production activity, were reached. This review presents and discusses the recent developments in biohydrogen production, with a focus on metabolic pathway engineering.
journal_name
Bioresour Technoljournal_title
Bioresource technologyauthors
Oh YK,Raj SM,Jung GY,Park Sdoi
10.1016/j.biortech.2011.04.054subject
Has Abstractpub_date
2011-09-01 00:00:00pages
8357-67issue
18eissn
0960-8524issn
1873-2976pii
S0960-8524(11)00568-2journal_volume
102pub_type
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