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Polycomb-mediated repression during terminal differentiation: what don't you want to be when you grow up?

Abstract：

:Chromatin-modifying enzymes are known to be critical components for the correct differentiation of embryonic stem cells into specific lineages, such as neurons. Recently, the role of Polycomb group proteins has been studied in the specification and differentiation of muscle stem cells. In this perspective, we review a recent study by Juan and colleagues (pp. 789-794) in Genes & Development of the role of the polycomb group protein Ezh2 in muscle stem cells, and discuss the implications for general lineage restriction.

journal_name

Genes Dev

journal_title

Genes & development

authors

Conerly ML,MacQuarrie KL,Fong AP,Yao Z,Tapscott SJ

doi

10.1101/gad.2054311

subject

Has Abstract

pub_date

2011-05-15 00:00:00

pages

997-1003

issue

10

eissn

0890-9369

issn

1549-5477

pii

25/10/997

journal_volume

25

pub_type

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