Abstract：
:Regulated cell expansion is an important determinant of organ shape in higher plants. The sabre mutation results in abnormal cell expansion in Arabidopsis. There is a shift in the orientation of expansion evident primarily in root cortex cells. The SABRE gene has been cloned and found to encode a novel protein. Reduction of effective levels of the plant phytohormone ethylene through use of inhibitors and an insensitive mutant resulted in partial rescue of the sabre phenotype. This suggested that one of the roles of SABRE is to counter the action of ethylene in promoting radial expansion in plant cells.
journal_name
Genes Devjournal_title
Genes & developmentauthors
Aeschbacher RA,Hauser MT,Feldmann KA,Benfey PNdoi
10.1101/gad.9.3.330subject
Has Abstractpub_date
1995-02-01 00:00:00pages
330-40issue
3eissn
0890-9369issn
1549-5477journal_volume
9pub_type
杂志文章abstract：:Transcription of bacteriophage N4 middle genes is carried out by a phage-coded, heterodimeric RNA polymerase (N4 RNAPII), which belongs to the family of T7-like RNA polymerases. In contrast to phage T7-RNAP, N4 RNAPII displays no activity on double-stranded templates and low activity on single-stranded templates. In v...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1121403
更新日期：2003-09-15 00:00:00
abstract：:Bone metastases are the most common skeletal complication of malignancy. Tumor cells disrupt normal bone remodeling to promote bone destruction and its associated morbidity. In the August 15, 2009, issue of Genes & Development, Lu and colleagues (pp. 1882-1894) propose a novel molecular mechanism by which tumor-produc...
journal_title：Genes & development
pub_type： 评论,杂志文章
doi：10.1101/gad.1854909
更新日期：2009-09-15 00:00:00
abstract：:Signals from TGF-beta superfamily receptors are transduced to the nucleus by Smad proteins, which transcriptionally activate target genes. In Caenorhabditis elegans, defects in a TGF-beta-related pathway cause a reversible developmental arrest and metabolic shift at the dauer larval stage. Null mutations in daf-3 supp...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.11.20.2679
更新日期：1997-10-15 00:00:00
abstract：:cappuccino and spire are unique Drosophila maternal-effect loci that participate in pattern formation in both the anteroposterior and dorsoventral axes of the early embryo. Mutant females produce embryos lacking pole cells, polar granules, and normal abdominal segmentation. They share these defects with the posterior ...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.3.9.1437
更新日期：1989-09-01 00:00:00
abstract：:Atypical teratoid rhabdoid tumors (ATRTs) are challenging pediatric brain cancers that are predominantly associated with inactivation of the gene SMARCB1, a conserved subunit of the chromatin remodeling BAF complex, which has known contributions to developmental processes. To identify potential interactions between SM...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.339978.120
更新日期：2020-10-01 00:00:00
abstract：:The Hox-2 locus on chromosome 11 represents one of the major clusters of homeo-box-containing genes in the mouse. We have identified two new members (Hox-2.6 and Hox-2.7), which form part of this cluster of seven linked genes, and it appears that the Hox-2 locus is related by duplication and divergence to at least one...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.2.11.1424
更新日期：1988-11-01 00:00:00
abstract：:Members of the metazoan nuclear receptor superfamily regulate gene expression programs in response to binding of cognate lipophilic ligands. Evolutionary studies using bioinformatics tools have concluded that lower eukaryotes, such as fungi, lack nuclear receptor homologs. Here we review recent discoveries suggesting ...
journal_title：Genes & development
pub_type： 杂志文章,评审
doi：10.1101/gad.1743009
更新日期：2009-02-15 00:00:00
abstract：:Eukaryotic translation initiation begins with ribosomal recruitment of aminoacylated initiator tRNA (Met-tRNA(Met)(i)) by eukaryotic initiation factor eIF2. In cooperation with eIF3, eIF1, and eIF1A, Met-tRNA(Met)(i)/eIF2/GTP binds to 40S subunits yielding 43S preinitiation complexes that attach to the 5'-terminal reg...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1957510
更新日期：2010-08-15 00:00:00
abstract：:A major class of bacterial small RNAs (sRNAs), along with RNA-binding protein Hfq and endoribonuclease RNase E, acts on target mRNAs through base-pairing, leading to translational repression and rapid degradation of the mRNAs. In this issue of Genes & Development, Prévost and colleagues (pp. 385-396) demonstrate by us...
journal_title：Genes & development
pub_type： 评论,杂志文章
doi：10.1101/gad.2030311
更新日期：2011-02-15 00:00:00
abstract：:U4 and U6 small nuclear RNAs are associated by an extensive base-pairing interaction that must be disrupted and reformed with each round of splicing. U4 mutations within the U4/U6 interaction domain destabilize the complex in vitro and cause a cold-sensitive phenotype in vivo. Restabilization of the U4/U6 helix by dom...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.5.5.773
更新日期：1991-05-01 00:00:00
abstract：:Plectin, a major linker and scaffolding protein of the cytoskeleton, has been shown to be essential for the mechanical integrity of skin, skeletal muscle, and heart. Studying fibroblast and astroglial cell cultures derived from plectin (-/-) mice, we found that their actin cytoskeleton, including focal adhesion contac...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.12.21.3442
更新日期：1998-11-01 00:00:00
abstract：:Integrin-mediated cell-matrix interactions are essential for development, tissue homeostasis, and repair. Upon ligand binding, integrins are recruited into focal adhesions (FAs). Integrin-linked kinase (ILK) is an FA component that interacts with the cytoplasmic domains of integrins, recruits adaptor proteins that lin...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.255603
更新日期：2003-04-01 00:00:00
abstract：:The Brr2 helicase provides the key remodeling activity for spliceosome catalytic activation, during which it disrupts the U4/U6 di-snRNP (small nuclear RNA protein), and its activity has to be tightly regulated. Brr2 exhibits an unusual architecture, including an ∼ 500-residue N-terminal region, whose functions and mo...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.271528.115
更新日期：2015-12-15 00:00:00
abstract：:The canoemisty1 (cnomis1) mutation was isolated by virtue of its severe rough eye phenotype from approximately 500 fly lines, each harboring a single autosomal insertion of a P element (Bm delta w). Excision of the P element generated a lethal, null allele, cnomis10, together with many revertants with normal eye morph...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.9.5.612
更新日期：1995-03-01 00:00:00
abstract：:This year is the centenary of Edward G. Conklin's signal findings in embryology: the elucidation of complete cell lineages and the discovery of localized maternal determinants. Conklin used ascidian embryos to elucidate universal principles in embryology. A century later, ascidians, or sea squirts, have not only enter...
journal_title：Genes & development
pub_type： 杂志文章,评审
doi：10.1101/gad.1365805
更新日期：2005-10-15 00:00:00
abstract：:Staurosporine, a potent inhibitor of protein kinase C, arrests fission yeast cell elongation specifically at a stage immediately after cell division. We isolated two genes, which, when carried on multicopy plasmids, confer drug resistance in fission yeast. One, spk1+, encodes a protein kinase highly similar (54% ident...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.5.1.60
更新日期：1991-01-01 00:00:00
abstract：:Nonsense-mediated decay (NMD) is a translation-dependent RNA quality control mechanism that occurs in the cytoplasm. However, it is unknown how NMD regulates the stability of RNAs translated at the endoplasmic reticulum (ER). Here, we identify a localized NMD pathway dedicated to ER-translated mRNAs. We previously ide...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.338061.120
更新日期：2020-08-01 00:00:00
abstract：:The molecular mechanisms driving brain development at risk in autism spectrum disorders (ASDs) remain mostly unknown. Previous studies have implicated the transcription factor FOXP1 in both brain development and ASD pathophysiology. However, the specific molecular pathways both upstream of and downstream from FOXP1 ar...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.305037.117
更新日期：2017-10-15 00:00:00
abstract：:The abundance of retinoic acid (RA) is determined by the balance between its synthesis by retinaldehyde dehydrogenase (RALDH) and its degradation by CYP26. In particular, the dynamic expression of three CYP26 genes controls the regional level of RA within the body. Pregastrulation mouse embryos express CYP26 but not R...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1776209
更新日期：2009-07-15 00:00:00
abstract：:Stem cells do not all respond the same way, but the mechanisms underlying this heterogeneity are not well understood. Here, we found that expression of Hes1 and its downstream genes oscillate in mouse embryonic stem (ES) cells. Those expressing low and high levels of Hes1 tended to differentiate into neural and mesode...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1823109
更新日期：2009-08-15 00:00:00
abstract：:TGF-β receptors phosphorylate SMAD2 and SMAD3 transcription factors, which then form heterotrimeric complexes with SMAD4 and cooperate with context-specific transcription factors to activate target genes. Here we provide biochemical and structural evidence showing that binding of SMAD2 to DNA depends on the conformati...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.330837.119
更新日期：2019-11-01 00:00:00
abstract：:Mammalian cells exhibit a complex response to DNA damage. The tumor suppressor BRCA1 and associated protein BARD1 are thought to play an important role in this response, and our previous work demonstrated that this includes transient inhibition of the pre-mRNA 3' processing machinery. Here we provide evidence that thi...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1309505
更新日期：2005-05-15 00:00:00
abstract：:We characterized a gene, extradenticle, which seems to interact with a specific subset of Drosophila homeo domain proteins, possibly affecting their target specificity. This interpretation is based on an examination of the zygotic and maternal effect phenotypes of extradenticle mutations. In embryos with reduced level...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.4.7.1209
更新日期：1990-07-01 00:00:00
abstract：:Historically, biomedical research has been based on two paradigms. First, measurements of biological behaviors have been based on bulk assays that average over large populations. Second, these behaviors have then been crudely perturbed by systemic administration of therapeutic treatments. Nanotechnology has the potent...
journal_title：Genes & development
pub_type： 杂志文章,评审
doi：10.1101/gad.226837.113
更新日期：2013-11-15 00:00:00
abstract：:Estrogen receptor α (ER) is the major driver of ∼75% of breast cancers, and multiple ER targeting drugs are routinely used clinically to treat patients with ER+ breast cancer. However, many patients relapse on these targeted therapies and ultimately develop metastatic and incurable disease, and understanding the mecha...
journal_title：Genes & development
pub_type： 杂志文章,评审
doi：10.1101/gad.316646.118
更新日期：2018-09-01 00:00:00
abstract：:Smads regulate transcription of defined genes in response to TGF-beta receptor activation, although the mechanisms of Smad-mediated transcription are not well understood. We demonstrate that the TGF-beta-inducible Smad3 uses the tumor suppressor Smad4/DPC4 and CBP/p300 as transcriptional coactivators, which associate ...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.12.14.2153
更新日期：1998-07-15 00:00:00
abstract：:The P family of transposable elements in Drosophila transpose by a cut-and-paste mechanism involving double-strand gap repair. We report here that a Drosophila mutagen-sensitive mutant, mus3O9, contains a mutation in IRBP (inverted repeat binding protein), the Drosophila homolog of the mammalian Ku p70 gene. We show t...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.10.8.921
更新日期：1996-04-15 00:00:00
abstract：:Growth of numerous cancer types is believed to be driven by a subpopulation of poorly differentiated cells, often referred to as cancer stem cells (CSCs), that have the capacity for self-renewal, tumor initiation, and generation of nontumorigenic progeny. Despite their potentially key role in tumor establishment and m...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.188292.112
更新日期：2012-09-01 00:00:00
abstract：:We identify the "M region" of the muscle-specific Xenopus cardiac actin gene promoter from -282 to -348 as necessary for the embryonic expression of a cardiac actin-beta-globin reporter gene injected into fertilized eggs. Four DNA-binding activities in embryo extracts, embryonic M-region factors 1-4 (EMF1-4), are desc...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.5.7.1149
更新日期：1991-07-01 00:00:00
abstract：:We have shown that Wnt signals are necessary and sufficient for neural crest cells to adopt pigment cell fates. nacre, a zebrafish homolog of MITF, is required for pigment cell differentiation. We isolated a promoter region of nacre that contains Tcf/Lef binding sites, which can mediate Wnt responsiveness. This promot...
journal_title：Genes & development
pub_type： 杂志文章
doi：
更新日期：2000-01-15 00:00:00
