High selenium intake and increased diabetes risk: experimental evidence for interplay between selenium and carbohydrate metabolism.

abstract：:Neutrophil accumulation within epithelial crypts and in the intestinal mucosa directly correlates with clinical disease activity and epithelial injury in ulcerative colitis (UC). Current advances have defined the mechanisms by which neutrophils are activated or migrate across mucosal epithelia. A better understanding ...

journal_title：Journal of clinical biochemistry and nutrition

authors： Naito Y,Takagi T,Yoshikawa T

更新日期：2007-07-01 00:00:00

abstract：:Intestinal ischemia/reperfusion injury is a severe disease associated with a high mortality. The mechanisms that cause ischemia/reperfusion injury are complex and many factors are involved in the injury formation process; however, the only available treatment is surgical intervention. Recent studies demonstrated that ...

journal_title：Journal of clinical biochemistry and nutrition

authors： Nadatani Y,Watanabe T,Shimada S,Otani K,Tanigawa T,Fujiwara Y

更新日期：2018-07-01 00:00:00

abstract：:The effects of topical application of Rafflesia hasseltii buds and flowers extract on the rate of wound healing and histology of healed wound were assessed. Four groups of adult male Sprague Dawley rats were experimentally wounded in the posterior neck area. A thin layer of blank placebo was applied topically to wound...

journal_title：Journal of clinical biochemistry and nutrition

authors： Abdulla MA,Ahmed KA,Ali HM,Noor SM,Ismail S

更新日期：2009-11-01 00:00:00

abstract：:Resistance to anti-fungal drugs has become the main cause for increasing incidence rate of Candida infections in pediatric intensive care units (PICU). Zinc supplementation has been shown to exhibit beneficial effects on many pediatric illnesses. This study aimed to investigate the efficacy of zinc supplementation on ...

journal_title：Journal of clinical biochemistry and nutrition

authors： Xie J,Zhu L,Zhu T,Jian Y,Ding Y,Zhou M,Feng X

更新日期：2019-03-01 00:00:00

abstract：:Citrus bioflavonoids may offer some protection against the early stage of diabetes mellitus and the development of complications. We investigated the effect of hesperidin on blood glucose levels, hepatic glucose-regulating enzyme activities, serum insulin and adiponectin levels, serum and hepatic lipid levels, and par...

journal_title：Journal of clinical biochemistry and nutrition

authors： Akiyama S,Katsumata S,Suzuki K,Ishimi Y,Wu J,Uehara M

更新日期：2010-01-01 00:00:00

abstract：:Parkinson's disease is a major neurodegenerative disease involving the selective degeneration of dopaminergic neurons and α-synuclein containing Lewy bodies formation in the substantia nigra. Although α-synuclein is a key molecule for both dopaminergic neuron death and the formation of inclusion bodies, the mechanism ...

journal_title：Journal of clinical biochemistry and nutrition

authors： Teraoka M,Nakaso K,Kusumoto C,Katano S,Tajima N,Yamashita A,Zushi T,Ito S,Matsura T

更新日期：2012-09-01 00:00:00

abstract：:Although carbon monoxide derived from heme oxygenase has been reported to exert diverse biological actions in mammals, macromolecules responsible for its direct reception and functional outcomes of the gas binding remain largely unknown. Based on our previous results in vivo suggesting carbon monoxide serves as an inh...

journal_title：Journal of clinical biochemistry and nutrition

authors： Yamamoto T,Takano N,Ishiwata K,Suematsu M

更新日期：2011-01-01 00:00:00

abstract：:Gastrointestinal symptoms are a problematic issue for patients who take low-dose aspirin for long time. We conducted a pilot study to investigate the efficacy of combination therapy with proton pump inhibitor and rebamipide. This was a prospective, randomized, double-blind, placebo-controlled cross-over study. All the...

journal_title：Journal of clinical biochemistry and nutrition

authors： Mizukami K,Murakami K,Hirashita Y,Hisamatsu A,Ogawa R,Uchida M,Nakagawa Y,Okimoto T,Kodama M,Fujioka T

更新日期：2012-11-01 00:00:00

abstract：:Colon cancer prevalence is high worldwide. O-GlcNAcylation has been associated with tumor growth in various tissues, including the colon; however, its link to carcinogenesis is not fully understood. We investigated the association of O-GlcNAcylation with colon carcinogenesis using a 1,2-dimethylhydrazine/dextran sodiu...

journal_title：Journal of clinical biochemistry and nutrition

authors： Hirata Y,Nakagawa T,Moriwaki K,Koubayashi E,Kakimoto K,Takeuchi T,Inoue T,Higuchi K,Asahi M

更新日期：2018-05-01 00:00:00

abstract：:Although atopic dermatitis is known to be closely associated with food antigens, the actual changes in the gastrointestinal tract have not been clarified. The aim of this study was to investigate the macroscopic and histological features of the large intestine in patients with atopic dermatitis. We studied 15 outpatie...

journal_title：Journal of clinical biochemistry and nutrition

authors： Arisawa T,Arisawa S,Yokoi T,Kuroda M,Hirata I,Nakano H

更新日期：2007-01-01 00:00:00

abstract：:Recently, it has been reported that α-tocopherol (α-Toc) is effective for amelioration of liver damage. However, it is unknown whether other vitamin E analogs are effective. In this study, we investigated the effects of γ-tocopherol (γ-Toc) and tocotrienols (T3) in rats with fatty liver. Rats fed a vitamin E-deficient...

journal_title：Journal of clinical biochemistry and nutrition

authors： Yachi R,Igarashi O,Kiyose C

更新日期：2010-09-01 00:00:00

abstract：:We investigated the effect of the sodium glucose cotransporter-2 inhibitor (SGLT-2i) luseogliflozin on skeletal muscle. Eight-week-old mice were fed a standard diet or the standard diet with added luseogliflozin for 8 weeks. The mice were divided into the following four genotype/dietary groups: Db/m mice without SGLT-...

journal_title：Journal of clinical biochemistry and nutrition

authors： Okamura T,Hashimoto Y,Osaka T,Fukuda T,Hamaguchi M,Fukui M

更新日期：2019-07-01 00:00:00

abstract：:It is accepted that pulmonary exposure of rodents to porcine pancreatic elastase (ELT) induces lesions that morphologically resemble human emphysema. Nonetheless, extensive analysis of this model has rarely been conducted. The present study was designed to extensively examine the effects of ELT on lung inflammation, c...

journal_title：Journal of clinical biochemistry and nutrition

authors： Inoue K,Koike E,Yanagisawa R,Takano H

更新日期：2010-03-01 00:00:00

abstract：:Prostaglandin E2 plays a role in an array of pathophysiological responses, including inflammation, carcinogenesis and so on. Prostaglandin E2 is synthesized from arachidonic acid by the enzymes cyclooxygenase and prostaglandin E synthase. In some pathological conditions, the isozymes cyclooxygenase-2 and microsomal pr...

journal_title：Journal of clinical biochemistry and nutrition

authors： Suzuki-Yamamoto T,Tanaka S,Tsukayama I,Takafuji M,Hanada T,Arakawa T,Kawakami Y,Kimoto M,Takahashi Y

更新日期：2014-11-01 00:00:00

abstract：:Recently, we administered fish oil containing eicosapentaenoic acid and docosahexaenoic acid (DHA) to senescence-accelerated mice P8 (SAMP8), in order to investigate the effects on lifespan. Surprisingly, the lifespan of SAMP8 that were fed fish oil was shortened significantly, through a mechanism that likely involved...

journal_title：Journal of clinical biochemistry and nutrition

authors： Sugawara S,Honma T,Ito J,Kijima R,Tsuduki T

更新日期：2013-03-01 00:00:00

abstract：:Geranylgeranoic acid, a 20-carbon polyprenoic acid (all-trans 3,7,11,15-tetramethyl-2,4,6,10,14-hexadecatetraenoic acid) and its derivatives were previously developed as synthetic "acyclic retinoids" for cancer chemoprevention. Recently, we demonstrated the natural occurrence of geranylgeranoic acid in various medicin...

journal_title：Journal of clinical biochemistry and nutrition

authors： Muraguchi T,Okamoto K,Mitake M,Ogawa H,Shidoji Y

更新日期：2011-07-01 00:00:00

abstract：:The present study was conducted to assess the association between 25-hydroxyvitamin D [25(OH)D], estimated glomerular filtration rate (eGFR) and urine microalbumin/creatinine ratio (uACR) in Korean adults. Data on 4,948 adults aged ≥20 years from the Korean National Health and Nutrition Examination Survey V-3 (2012) w...

journal_title：Journal of clinical biochemistry and nutrition

authors： Kim SG,Kim GS,Lee JH,Moon AE,Yoon H

更新日期：2018-01-01 00:00:00

abstract：:This study investigated the effects of a drink supplement containing Momordica charantia extract from bitter melon on physical fitness and levels of stress hormones during a four-week exercise training program in a hot environment. Ten male tennis players were orally administrated in a four-week (100 ml, 6 times a day...

journal_title：Journal of clinical biochemistry and nutrition

authors： Yook JS,Kwak JJ,Jeong WM,Song YH,Hijioka Y,Honda Y,Kim SE,Ha MS

更新日期：2020-11-01 00:00:00

abstract：:Selenoprotein P (encoded by SELENOP) contains the essential trace element selenium in the form of selenocysteine, which is an analog of cysteine that contains selenium instead of sulfur. Selenoprotein P is a major selenium-containing protein in human plasma and is mainly synthesized in the liver. It functions as a sel...

journal_title：Journal of clinical biochemistry and nutrition

authors： Saito Y

更新日期：2020-01-01 00:00:00

abstract：:Although some studies have indicated a correlation between Helicobacter pylori infection and the risk of colorectal neoplasms, these findings have not been consistent and are controversial. This case-control study aimed to investigate the association between endoscopic gastric mucosal atrophy and colorectal polyp occu...

journal_title：Journal of clinical biochemistry and nutrition

authors： Kawahara Y,Kodama M,Mizukami K,Saito T,Hirashita Y,Sonoda A,Fukuda K,Matsunari O,Okamoto K,Ogawa R,Okimoto T,Murakami K

更新日期：2019-09-01 00:00:00

abstract：:Proton pump inhibitors (PPIs) are now commonly used for the treatment of acid related diseases such as peptic ulcer and reflux esophagitis. Because of their ability to produce direct inhibition of the proton pump, PPIs provide more sustained increase of the gastric pH than H(2)-receptor (H(2)R) antagonists. Diverse re...

journal_title：Journal of clinical biochemistry and nutrition

authors： Masaoka T,Suzuki H,Hibi T

更新日期：2008-05-01 00:00:00

abstract：:The pathophysiology of hypertension or stroke is associated with an excess of ROS generation in the vascular system, and results in induction of various pathological cascades of cerebrovascular damage. We have demonstrated that electron spin resonance methods using a spin trap or spin probe will be useful for understa...

journal_title：Journal of clinical biochemistry and nutrition

authors： Lee MC

更新日期：2013-01-01 00:00:00

abstract：:Although the accumulation of advanced glycation end-products (AGEs) of the Maillard reaction in our body is reported to increase with aging and is enhanced by the pathogenesis of lifestyle-related diseases such as diabetes, routine measurement of AGEs is not applied to regular clinical diagnoses due to the lack of con...

journal_title：Journal of clinical biochemistry and nutrition

authors： Yamanaka M,Matsumura T,Ohno R,Fujiwara Y,Shinagawa M,Sugawa H,Hatano K,Shirakawa J,Kinoshita H,Ito K,Sakata N,Araki E,Nagai R

更新日期：2016-03-01 00:00:00

abstract：:This study aimed to consider the significance of breast milk in preventing oxidative stress by comparing total antioxidant capacity (TAC) in breast milk and formula milk for premature infants, demonstrating the relationship between TAC in breast milk and postnatal age in days. We used the biological anti-oxidant poten...

journal_title：Journal of clinical biochemistry and nutrition

authors： Ezaki S,Ito T,Suzuki K,Tamura M

更新日期：2008-03-01 00:00:00

abstract：:Secretory immunoglobulin A (sIgA) is produced from intestinal mucosa and is essential in preventing infection. We analyzed the influence of moderate exercise on intestinal sIgA production and antioxidative function under different carbohydrate nutritional conditions. Thirty-six mice were fed an experimental diet for 1...

journal_title：Journal of clinical biochemistry and nutrition

authors： Shibuya T,Kaburagi T,Nagai R,Oshiro S

更新日期：2015-07-01 00:00:00

abstract：:Anti-peptic and anti-inflammatory actions of ecabet sodium might be beneficial in either improving gastritis or relieving dyspeptic symptoms. This study was designed to evaluate the clinical efficacy of ecabet sodium on dyspeptic symptoms and to elucidate the molecular mechanism attributable to symptom relief in patie...

journal_title：Journal of clinical biochemistry and nutrition

authors： Yang Kim H,Hahm KB,Choi MG,Rew JS,Seol SY,Chun HJ,Lee OY,Hong WS

更新日期：2007-11-01 00:00:00

abstract：:We assessed the effect of multi-species probiotic mixture on the changes in fecal microbiota and irritable bowel syndrome (IBS) symptoms. Eighty-one IBS patients were randomly assigned to receive either probiotic mixture (n = 39; containing Lactobacillus acidophilus, L. rhamnosus, Bifidobacterium breve, B. actis, B. l...

journal_title：Journal of clinical biochemistry and nutrition

authors： Yoon H,Park YS,Lee DH,Seo JG,Shin CM,Kim N

更新日期：2015-09-01 00:00:00

abstract：:The fatty acid composition of serum phospholipids were analyzed in 20 patients with alcoholic liver cirrhosis (11 with malnutrition and 9 with acceptable nutritional status); 25 healthy age and sex-matched adults were used as controls. Cirrhotic patients showed higher levels of palmitic acid and total saturated fatty ...

journal_title：Journal of clinical biochemistry and nutrition

authors： Ristić-Medić D,Takić M,Vučić V,Kandić D,Kostić N,Glibetić M

更新日期：2013-07-01 00:00:00

abstract：:Kangen-karyu, a prescription containing six herbs, has been shown to achieve its pharmacological effect through oxidative stress-dependent pathways in animal models. The aim of this study is to investigate the relationship between the antioxidative effect and pharmacological mechanisms of Kangen-karyu, specifically it...

journal_title：Journal of clinical biochemistry and nutrition

authors： Hirayama A,Okamoto T,Kimura S,Nagano Y,Matsui H,Tomita T,Oowada S,Aoyagi K

更新日期：2016-05-01 00:00:00

abstract：:Nutritional and immunological status of patients with obstructive jaundice is usually severely altered, with high mortality rates. The n-3 polyunsaturate fatty acids (PUFA), particularly eicosapentaenoic acid (EPA, 20:5 n-3), posess potent immunomodulatory activities. Thus, our aim was to compare the plasma phospholip...

journal_title：Journal of clinical biochemistry and nutrition

authors： Popovic T,Ranic M,Bulajic P,Milicevic M,Arsic A,Vucic V,Glibetic M

更新日期：2009-11-01 00:00:00