Comparison of the in vivo hemodynamic effects of the antiarrhythmic agents vernakalant and flecainide in a rat hindlimb perfusion model.

abstract：:A number of studies using endothelin (ET) precursors, commonly termed big ETs, have revealed the presence of endothelin-converting enzyme (ECE) activity in various vascular and nonvascular preparations. Since then, more than one ECE has been cloned. It has also been observed that big ET-1 and big ET-3 are not converte...

journal_title：Journal of cardiovascular pharmacology

authors： Rizzi A,Calo G,Battistini B,Regoli D

更新日期：1998-01-01 00:00:00

abstract：:The hypothesis that local release of prostanoids may contribute to the pharmacologic effect of nitroglycerin (NTG) has long been debated. Results of prostanoid blockade by indomethacin on NTG-induced effects, to date, have been inconclusive. To quantitate the effects of intravenous indomethacin on NTG-induced myocardi...

journal_title：Journal of cardiovascular pharmacology

authors： Bednarcyzk EM,Furniss SM,Green JA,Munger MA

更新日期：1997-12-01 00:00:00

abstract：:MDL 19205 4-ethyl-1-,3-dihydro-5-(4-pyridinylcarbonyl)-2H-imidazol-2-one, a new cardioactive agent, has been shown to increase myocardial contractile force in animals. It is effective by both oral and intravenous routes. We studied 11 patients with congestive heart failure--in 10 cases owing to coronary artery disease...

journal_title：Journal of cardiovascular pharmacology

authors： Cottier C,Follath F,Kiowski W,Pfisterer M,Emmenegger H,Burkart F

更新日期：1987-02-01 00:00:00

abstract：:The positive inotropic effect of DPI 201-106 has been studied in isolated, electrically driven papillary muscles of spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WK). The positive inotropic effect of isoprenaline (Iso) and Ca2+ was studied for comparison. The maximal positive inotropic effect of Iso was...

journal_title：Journal of cardiovascular pharmacology

authors： Böhm M,Diet F,Erdmann E

更新日期：1988-04-01 00:00:00

abstract：:Dilevalol, the stereoisomer of labetalol, was given in repeated incremental intravenous bolus injections to 10 patients with severe hypertension requiring urgent blood pressure lowering. The mean cumulative dose of dilevalol was 445 +/- 165 mg. Blood pressure was reduced from 201 +/- 33/131 +/- 13 to 150 +/- 12/109 +/...

journal_title：Journal of cardiovascular pharmacology

authors： Bursztyn M,Gavras I,Blasucci DJ,Gavras H

更新日期：1989-05-01 00:00:00

abstract：:Drug-induced delayed cardiac repolarization is a recognized risk factor for proarrhythmia and is associated with block of IKr (the potassium current encoded by the human ether-a- go-go-related gene [hERG]). To evaluate the utility of 2 in vitro assays widely used to assess delayed repolarization, we compared the effec...

journal_title：Journal of cardiovascular pharmacology

authors： Martin RL,McDermott JS,Salmen HJ,Palmatier J,Cox BF,Gintant GA

更新日期：2004-03-01 00:00:00

abstract：:Erythrocyte lithium-sodium countertransport, a mode of ouabain-insensitive monovalent cation metabolism, is increased in human essential hypertension, but no pathophysiological link to hypertension has yet been established. Similarities between red cell lithium-sodium countertransport and renal proximal tubular sodium...

journal_title：Journal of cardiovascular pharmacology

authors： Weder AB,Fitzpatrick MA

更新日期：1986-01-01 00:00:00

abstract：:Previous studies have suggested that prazosin is a selective post-synaptic alpha-receptor blocker. It has also been suggested that it may have greater blocking actions on arterioles than on venous beds. These aspects have been investigated in cats anesthetized with pentobarbital. Prazosin had no effect on conductance ...

journal_title：Journal of cardiovascular pharmacology

authors： Patel P,Bose D,Greenway C

更新日期：1981-09-01 00:00:00

abstract：:The elimination of an acute oral saline load is markedly blunted in adult Sabra hypertension-prone (SBH) rats compared with hypertension-resistant Sabra normotensive (SBN) rats. Within 2 h, urinary output and the excretion of sodium and potassium are significantly reduced, while urine osmolality is markedly elevated i...

journal_title：Journal of cardiovascular pharmacology

authors： Mekler J,Ben-Ishay D,Garthoff B,Kazda S

更新日期：1987-01-01 00:00:00

abstract：:During the last few years, there has been a growing awareness that treated hypertensive patients are still at substantially increased risks for cardiovascular morbidity and mortality and that one conceivable explanation for this is that their blood pressure has not been lowered to strictly normotensive levels. To obta...

journal_title：Journal of cardiovascular pharmacology

authors： Dahlöf B,Eggertsen R,Hansson L

更新日期：1988-01-01 00:00:00

abstract：:This article reviews the relation of cardiac cellular Na+ load and increased force of contraction. Digitalis glycosides and naturally occurring Na+ channel activators are considered. DPI201-106 was described as the first synthetic organic molecule with cardioselective Na+ channel-activating properties and investigated...

journal_title：Journal of cardiovascular pharmacology

authors： Scholtysik G

更新日期：1989-01-01 00:00:00

abstract：:When the cervical vagus nerve is briefly stimulated, a triphasic cardiac chronotropic response ensues: the cardiac cycle length initially increases, then briefly decreases, and subsequently increases again. Verapamil, a calcium channel blocker, alters these responses to acetylcholine when the heart is in sinoatrial no...

journal_title：Journal of cardiovascular pharmacology

authors： Wallick DW,Stuesse SL,Crafford W

更新日期：1988-07-01 00:00:00

abstract：:Cardiovascular effects of Nifekalant were examined using halothane-anesthetized dogs, and its proarrhythmic potential was estimated with chronic complete atrioventricular block dogs. Nifekalant was intravenously administered to the halothane-anesthetized dogs in three doses of 0.03, 0.3, and 3 mg/kg/10 minutes with a ...

journal_title：Journal of cardiovascular pharmacology

authors： Satoh Y,Sugiyama A,Takahara A,Chiba K,Hashimoto K

更新日期：2004-05-01 00:00:00

abstract：:A randomized, double-blind, crossover trial was carried out in 17 hypertensive patients to evaluate the hypotensive efficacy and safety of verapamil. Verapamil in doses of 120 mg thrice daily was compared with pindolol in doses of 7.5 mg twice daily. A thiazide diuretic was given with both drugs. Blood pressure fell a...

journal_title：Journal of cardiovascular pharmacology

authors： Anavekar SN,Christophidis N,Louis WJ,Doyle AE

更新日期：1981-03-01 00:00:00

abstract：:Nebivolol, a chemically novel beta 1-adrenoceptor antagonist, acutely lowers blood pressure in spontaneously hypertensive rats, anaesthetised normotensive dogs, and hypertensive patients. We have investigated the actions of dl-nebivolol in five conscious normotensive rabbits (sham, mean blood pressure (BP) of 82.2 +/-...

journal_title：Journal of cardiovascular pharmacology

authors： Ward JE,Coles P,Cox H,Eisenhofer G,Angus JA

更新日期：1992-07-01 00:00:00

abstract：:Vascular smooth muscle cells (SMCs) play a key role in the development of atherosclerotic lesions. Vascular smooth muscle, however, does not represent a homogeneous tissue. Using myosin as a marker of the differentiation processes in development and in vascular disease, we have been able to demonstrate the existence o...

journal_title：Journal of cardiovascular pharmacology

authors： Pauletto P,Sartore S,Giuriato L,Scatena M,Tonello M,Scannapieco G,Pessina AC,Dal Palù C

更新日期：1992-01-01 00:00:00

abstract：:The formation of bone occurs via a series of events that are regulated by various hormones and cytokines. We previously reported that endothelin (ET) inhibits the mineralization by osteoblastic cells and natriuretic peptide (NP) promotes osteoblastic differentiation. Therefore, we attempted to identify the genes induc...

journal_title：Journal of cardiovascular pharmacology

authors： Inoue A,Kamiya A,Ishiji A,Hiruma Y,Hirose S,Hagiwara H

更新日期：2000-11-01 00:00:00

abstract：:The mode of action of Crataegus extracts in the treatment of heart failure is still under examination. WS 1442, a standardized special extract from Crataegus leaves with flowers, exerts direct positive inotropic effects. This study was designed to investigate the mode of inotropic action of WS 1442 in human myocardium...

journal_title：Journal of cardiovascular pharmacology

authors： Schwinger RH,Pietsch M,Frank K,Brixius K

更新日期：2000-05-01 00:00:00

abstract：:The effect of two calcium antagonists on left ventricular (LV) relaxation and diastolic filling was evaluated in 16 randomized patients. Isradipine and nifedipine were administered intravenously in a maximum dose of 60 micrograms/min for isradipine and 63 micrograms/min for nifedipine. Heart rate was increased signifi...

journal_title：Journal of cardiovascular pharmacology

authors： Hoppeler H,Hess OM,Hug R,Turina J,Krayenbühl HP

更新日期：1990-01-01 00:00:00

abstract：:The acute, 60 min blood pressure and plasma renin responses to an oral test dose of captopril given to a quietly seated patient can be used to gain information quickly on renin dependency or lack of it in a hypertensive situation. This information is verified by a baseline renin sodium profile test. These two diagnost...

journal_title：Journal of cardiovascular pharmacology

authors： Laragh JH

更新日期：1985-01-01 00:00:00

abstract：:The effects of purified baicalin and baicalein from the traditional Chinese herb, Huangqin, on contractions induced by phenylephrine, U46619, and high extracellular K+ were investigated in isolated rat mesenteric arteries. Both baicalin (1-100 microM) and baicalein (1-50 microM) potentiated the contractile response to...

journal_title：Journal of cardiovascular pharmacology

authors： Tsang SY,Chen ZY,Yao XQ,Huang Y

更新日期：2000-08-01 00:00:00

abstract：:The extent to which posture altered the haemodynamic response to slow calcium channel blocker nicardipine was evaluated in 22 male patients with angiographically confirmed coronary artery disease. Patients were randomly allocated to supine or upright posture and an otherwise identical protocol performed in each group....

journal_title：Journal of cardiovascular pharmacology

authors： Silke B,Verma SP,Zezulka AV,Sharma S,Goldhammer E,Jackson N,Taylor SH

更新日期：1990-07-01 00:00:00

abstract：:Low density lipoprotein (LDL) oxidation plays a crucial role in the development and progression of atherosclerosis and is enhanced in patients with essential hypertension. This finding has stimulated a search for antihypertensive drugs with high intrinsic antioxidant properties. We investigated the antihypertensive an...

journal_title：Journal of cardiovascular pharmacology

authors： Maggi E,Marchesi E,Covini D,Negro C,Perani G,Bellomo G

更新日期：1996-04-01 00:00:00

abstract：:The cardioprotective effects of betaxolol were studied in a rat model with heart failure induced by autoimmune myocarditis. Twenty-eight days after immunization, Lewis rats were divided into four groups; 0.1 mg/kg betaxolol per day (group 0.1), 1.0 mg/kg betaxolol per day (group 1), 10 mg/kg betaxolol per day (group 1...

journal_title：Journal of cardiovascular pharmacology

authors： Watanabe K,Juan W,Narasimman G,Ma M,Inoue M,Saito Y,Wahed MI,Nakazawa M,Hasegawa G,Naito M,Tachikawa H,Tanabe N,Kodama M,Aizawa Y,Yamamoto T,Yamaguchi K,Takahashi T

更新日期：2003-01-01 00:00:00

abstract：:The effect of two dihydropyridine derivatives, nifedipine and felodipine, on myocardial blood flow distribution 1 h after ligation of the left anterior descending coronary artery (LAD) was studied in open-chest dogs by means of radioactive microspheres. The myocardium normally perfused from the LAD was first labeled w...

journal_title：Journal of cardiovascular pharmacology

authors： Sjöquist PO,Duker G,Almgren O

更新日期：1985-07-01 00:00:00

abstract：:We studied 11 previously refractory hypertensive subjects who were treated with minoxidil, propranolol, and diuretics for 2--7 years. During this time 70 random blood samples were collected in the supine position and analyzed for plasma norepinephrine (PNE) and plasma renin activity (PRA). The mean PNE was 546 pg/ml (...

journal_title：Journal of cardiovascular pharmacology

authors： Mitchell HC,Pettinger WA

更新日期：1980-01-01 00:00:00

abstract：:Defibrillation strength shocks delivered within an action potential (AP) delay repolarization. Shock-induced AP duration extension (APDE) may prolong refractoriness and terminate or prevent reinitiation of reentry, favoring defibrillation. This study examined LY-190147 (LY) effects on defibrillation threshold (DFT) in...

journal_title：Journal of cardiovascular pharmacology

authors： Beatch GN,Dickenson DR,Wood RH,Tang AS

更新日期：1996-02-01 00:00:00

abstract：:The cardiac electrophysiology of flecainide a new antiarrhythmic agent, was studied in open-chested dogs. At plasma concentrations of 0.4 to 0.7 microgram/ml, flecainide significantly prolonged atrioventricular (AV) conduction. At plasma concentrations greater than 6.5 micrograms/ml, flecainide caused delay throughout...

journal_title：Journal of cardiovascular pharmacology

authors： Hodess AB,Follansbee WP,Spear JF,Moore EN

更新日期：1979-07-01 00:00:00

abstract：:A contribution by active vasodilation to the hypotensive effect of medroxalol was investigated in anesthetized dogs and reserpinized pithed rats. In anesthetized dogs, intravenous doses of medroxalol, which decreased blood pressure and heart rate, also produced a dose-related vasodilation in the isolated perfused grac...

journal_title：Journal of cardiovascular pharmacology

authors： Dage RC,Hsieh CP,Spedding M

更新日期：1983-01-01 00:00:00

abstract：:BMY 20064 is a dihydropyridine Ca2+ entry blocker with potent and selective alpha 1-adrenoceptor antagonist properties. The drug was equal in potency to nifedipine as a Ca2+ entry blocker in depolarized smooth muscle preparations. It was less active than nifedipine in antagonizing Ca2+-induced contractions of isolated...

journal_title：Journal of cardiovascular pharmacology

authors： Stanton HC,Rosenberger LB,Hanson RC,Fleming JS,Poindexter GS

更新日期：1988-04-01 00:00:00