Abstract:
:The nitrile stretching vibration is increasingly used as a sensitive infrared probe of local protein environments. However, site-specific incorporation of a nitrile moiety into proteins is difficult. Here we show that various aromatic nitriles can be easily incorporated into peptides and proteins via either thiol alkylation or arylation reaction.
journal_name
Biochemistryjournal_title
Biochemistryauthors
Jo H,Culik RM,Korendovych IV,Degrado WF,Gai Fdoi
10.1021/bi101711asubject
Has Abstractpub_date
2010-12-14 00:00:00pages
10354-6issue
49eissn
0006-2960issn
1520-4995journal_volume
49pub_type
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