Abstract:
:In Drosophila melanogaster, achaete (ac) and m8 are model basic helix-loop-helix activator (bHLH A) and repressor genes, respectively, that have the opposite cell expression pattern in proneural clusters during Notch signaling. Previous studies have shown that activation of m8 transcription in specific cells within proneural clusters by Notch signaling is programmed by a "combinatorial" and "architectural" DNA transcription code containing binding sites for the Su(H) and proneural bHLH A proteins. Here we show the novel result that the ac promoter contains a similar combinatorial code of Su(H) and bHLH A binding sites but contains a different Su(H) site architectural code that does not mediate activation during Notch signaling, thus programming a cell expression pattern opposite that of m8 in proneural clusters.
journal_name
Mol Cell Bioljournal_title
Molecular and cellular biologyauthors
Cave JW,Xia L,Caudy Mdoi
10.1128/MCB.00003-10subject
Has Abstractpub_date
2011-01-01 00:00:00pages
22-9issue
1eissn
0270-7306issn
1098-5549pii
MCB.00003-10journal_volume
31pub_type
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