FOXN1 Transcription Factor in Epithelial Growth and Wound Healing.

abstract：:The numerous members of the steroid/nuclear hormone receptor superfamily act as direct transducers of circulating signals, such as steroids, thyroid hormone, and vitamin or lipid metabolites, and modulate the transcription of specific target genes, primarily as dimeric complexes. The receptors for 9-cis retinoic acid ...

journal_title：Molecular and cellular biology

authors： Lemon BD,Fondell JD,Freedman LP

更新日期：1997-04-01 00:00:00

abstract：:Smads 1, 5, and 8 are the intracellular mediators for the bone morphogenetic proteins (BMPs), which play crucial roles during mammalian development. Previous research has shown that Smad1 is important in the formation of the allantois, while Smad5 has been shown to be critical in the process of angiogenesis. To furthe...

journal_title：Molecular and cellular biology

authors： Hester M,Thompson JC,Mills J,Liu Y,El-Hodiri HM,Weinstein M

更新日期：2005-06-01 00:00:00

abstract：:The metabolic lifetime of mRNA can be specified by specific cis-acting elements within mRNA. One type of element is an adenylate- and uridylate-rich element (ARE) found in the 3' untranslated region of many highly unstable mRNAs for mammalian early-response genes (ERGs). Among the better-characterized members of the E...

journal_title：Molecular and cellular biology

authors： Chen CY,Shyu AB

更新日期：1994-12-01 00:00:00

abstract：:DNA from the centromere region of linkage group (LG) VII of Neurospora crassa was cloned previously from a yeast artificial chromosome library and was found to be atypical of Neurospora DNA in both composition (AT rich) and complexity (repetitive). We have determined the DNA sequence of a small portion (approximately ...

journal_title：Molecular and cellular biology

authors： Cambareri EB,Aisner R,Carbon J

更新日期：1998-09-01 00:00:00

abstract：:IME1 encodes a transcriptional activator required for the transcription of meiosis-specific genes and initiation of meiosis in Saccharomyces cerevisiae. The transcription of IME1 is repressed in the presence of glucose, and a low basal level of IME1 RNA is observed in vegetative cultures with acetate as the sole carbo...

journal_title：Molecular and cellular biology

authors： Sagee S,Sherman A,Shenhar G,Robzyk K,Ben-Doy N,Simchen G,Kassir Y

更新日期：1998-04-01 00:00:00

abstract：:Sequence data are presented for the Saccharomyces cerevisiae TAP1 gene and for a mutant allele, tap1-1, that activates transcription of the promoter-defective yeast SUP4 tRNA(Tyr) allele SUP4A53T61. The degree of in vivo activation of this allele by tap1-1 is strongly affected by the nature of the flanking DNA sequenc...

journal_title：Molecular and cellular biology

authors： Aldrich TL,Di Segni G,McConaughy BL,Keen NJ,Whelen S,Hall BD

更新日期：1993-06-01 00:00:00

abstract：:Expression of the recombinant human U1-70K protein in COS cells resulted in its rapid transport to the nucleus, even when binding to U1 RNA was debilitated. Deletion analysis of the U1-70K protein revealed the existence of two segments of the protein which were independently capable of nuclear localization. One nuclea...

journal_title：Molecular and cellular biology

authors： Romac JM,Graff DH,Keene JD

更新日期：1994-07-01 00:00:00

abstract：:Although largely involved in innate and adaptive immunity, NF-kappa B plays an important role in vertebrate development. In chicks, the inactivation of the NF-kappa B pathway induces functional alterations of the apical ectodermal ridge, which mediates limb outgrowth. In mice, the complete absence of NF-kappa B activi...

journal_title：Molecular and cellular biology

authors： Correa RG,Tergaonkar V,Ng JK,Dubova I,Izpisua-Belmonte JC,Verma IM

更新日期：2004-06-01 00:00:00

abstract：:Using nuclear runoff transcription assays we demonstrated that alpha interferon-mediated induction of transcription of four mRNAs in HeLa monolayer cells needed ongoing protein synthesis and that such a need could be obviated by pretreating the cells with gamma interferon which, by itself, did not induce transcription...

journal_title：Molecular and cellular biology

authors： Kusari J,Sen GC

更新日期：1987-01-01 00:00:00

abstract：:Although the splicing of transcripts from most eukaryotic genes occurs in a constitutive fashion, some genes can undergo a process of alternative splicing. This is a genetically economical process which allows a single gene to give rise to several protein isoforms by the inclusion or exclusion of sequences into or fro...

journal_title：Molecular and cellular biology

authors： Bell MV,Cowper AE,Lefranc MP,Bell JI,Screaton GR

更新日期：1998-10-01 00:00:00

abstract：:The pocket protein family of tumor suppressors, and Rb specifically, have been implicated as controlling terminal differentiation in many tissues, including the heart. To establish the biological functions of Rb in the heart and overcome the early lethality caused by germ line deletion of Rb, we used a Cre/loxP system...

journal_title：Molecular and cellular biology

authors： MacLellan WR,Garcia A,Oh H,Frenkel P,Jordan MC,Roos KP,Schneider MD

更新日期：2005-03-01 00:00:00

abstract：:Previous results of our cDNA microarray analysis to look for genes whose expression level correlates well with in vitro tubulogenesis by NP31 endothelial cells revealed the transcription factor ATF3 known to be responsive to stress such as reactive oxygen species (ROS). Anti-ATF3 small interfering RNA gave an inhibito...

journal_title：Molecular and cellular biology

authors： Okamoto A,Iwamoto Y,Maru Y

更新日期：2006-02-01 00:00:00

abstract：:It is well established that cell survival signals stimulated by growth factors, cytokines, and oncoproteins are initiated by phosphoinositide 3-kinase (PI3K)- and Akt-dependent signal transduction pathways. Oncogenic Ras, an upstream activator of Akt, requires NF-kappaB to initiate transformation, at least partially t...

journal_title：Molecular and cellular biology

authors： Madrid LV,Wang CY,Guttridge DC,Schottelius AJ,Baldwin AS Jr,Mayo MW

更新日期：2000-03-01 00:00:00

abstract：:TEL-JAK2 fusion proteins, which are a result of t(9;12)(p24;p13) translocations associated with human leukemia, activate Stat5 in vitro and in vivo and cause a myelo- and lymphoproliferative disease in a murine bone marrow transplant model. We report that Socs-1, a member of the SOCS family of endogenous inhibitors of...

journal_title：Molecular and cellular biology

authors： Frantsve J,Schwaller J,Sternberg DW,Kutok J,Gilliland DG

更新日期：2001-05-01 00:00:00

abstract：:It has been hypothesized that protein factors may protect CpG islands from methyltransferase during development and that demethylation may involve protein-DNA interactions at demethylated sites. However, direct evidence has been lacking. In this study, demethylation at the EBNA-1 binding sites of the Epstein-Barr viru...

journal_title：Molecular and cellular biology

authors： Hsieh CL

更新日期：1999-01-01 00:00:00

abstract：:We report our molecular characterization of the Drosophila melanogaster Abelson gene (abl), a gene in which recessive loss-of-function mutations result in lethality at the pupal stage of development. This essential gene consists of 10 exons extending over 26 kilobase pairs of genomic DNA. The DNA sequence encodes a pr...

journal_title：Molecular and cellular biology

authors： Henkemeyer MJ,Bennett RL,Gertler FB,Hoffmann FM

更新日期：1988-02-01 00:00:00

abstract：:Exposure of phosphatidylserine (PS) on the cell surface occurs early during apoptosis and serves as a recognition signal for phagocytes. Clearance of apoptotic cells by a membrane PS receptor is one of the critical anti-inflammatory functions of macrophages. However, the PS binding receptors and their recognition mech...

journal_title：Molecular and cellular biology

authors： Park SY,Kim SY,Jung MY,Bae DJ,Kim IS

更新日期：2008-09-01 00:00:00

abstract：:Viruses have developed numerous strategies to counteract the host cell defense. Kaposi's sarcoma-associated herpesvirus (KSHV) is a DNA tumor virus linked to the development of Kaposi's sarcoma, Castleman's disease, and primary effusion lymphoma (PEL). The virus-encoded viral interferon regulatory factor 3 (vIRF-3) ge...

journal_title：Molecular and cellular biology

authors： Baresova P,Musilova J,Pitha PM,Lubyova B

更新日期：2014-02-01 00:00:00

abstract：:The effect of atenolol, propranolol, trifluoperazine, and caffeine on the occurrence of meiotic diploid and disomic products in Saccharomyces cerevisiae was investigated. We demonstrated that atenolol, propranolol, and trifluoperazine reduce the occurrence of meiotic diploid products and that propranolol also slightly...

journal_title：Molecular and cellular biology

authors： Sora S,Bianchi M

更新日期：1982-11-01 00:00:00

abstract：:CD133, a widely known marker of cancer stem cells, was recently found in extracellular vesicles. However, the mechanisms underlying CD133 translocation to the extracellular space remain largely unknown. Here we report that CD133 is monoubiquitinated. Ubiquitination occurs primarily on complex glycosylated CD133. The l...

journal_title：Molecular and cellular biology

authors： Yang F,Xing Y,Li Y,Chen X,Jiang J,Ai Z,Wei Y

更新日期：2018-07-16 00:00:00

abstract：:The apoptotic process is accompanied by major changes in chromatin structure and gene expression. The apoptotic genetic program is progressively set up with the inhibition of antiapoptotic genes and the activation of proapoptotic ones. Here, we show that the histone deacetylase 3 (HDAC-3), which is a known co-represso...

journal_title：Molecular and cellular biology

authors： Escaffit F,Vaute O,Chevillard-Briet M,Segui B,Takami Y,Nakayama T,Trouche D

更新日期：2007-01-01 00:00:00

abstract：:C3G, which was identified as a Crk SH3 domain-binding guanine nucleotide-releasing factor, shows sequence similarity to CDC25 and Sos family proteins (S. Tanaka, T. Morishita, Y. Hashimoto, S. Hattori, S. Nakamura, M. Shibuya, K. Matuoka, T. Takenawa, T. Kurata, K. Nagashima, and M. Matsuda, Proc. Natl. Acad. Sci. USA...

journal_title：Molecular and cellular biology

authors： Gotoh T,Hattori S,Nakamura S,Kitayama H,Noda M,Takai Y,Kaibuchi K,Matsui H,Hatase O,Takahashi H

更新日期：1995-12-01 00:00:00

abstract：:In Saccharomyces cerevisiae, double-strand breaks (DSBs) activate DNA checkpoint pathways that trigger several responses including a strong G(2)/M arrest. We have previously provided evidence that the phosphatases Ptc2 and Ptc3 of the protein phosphatase 2C type are required for DNA checkpoint inactivation after a DSB...

journal_title：Molecular and cellular biology

authors： Guillemain G,Ma E,Mauger S,Miron S,Thai R,Guérois R,Ochsenbein F,Marsolier-Kergoat MC

更新日期：2007-05-01 00:00:00

abstract：:B-cell stimulatory factor 2 (BSF-2) is a lymphokine which induces the final maturation of B cells. BSF-2 acts on a variety of cells other than B cells, and moreover, expression of BSF-2 mRNA is detected in interleukin-1 beta-stimulated glioblastoma and astrocytoma cell lines. Here, we studied the function of BSF-2 on ...

journal_title：Molecular and cellular biology

authors： Satoh T,Nakamura S,Taga T,Matsuda T,Hirano T,Kishimoto T,Kaziro Y

更新日期：1988-08-01 00:00:00

abstract：:The use of small-molecule inhibitors to study molecular components of cellular signal transduction pathways provides a means of analysis complementary to currently used techniques, such as antisense, dominant-negative (interfering) mutants and constitutively activated mutants. We have identified and characterized a sm...

journal_title：Molecular and cellular biology

authors： Blake RA,Broome MA,Liu X,Wu J,Gishizky M,Sun L,Courtneidge SA

更新日期：2000-12-01 00:00:00

abstract：:In the present study we have analyzed the genetic regulation of increased expression of transformation-associated traits, a process termed progression, in adenovirus type 5 (Ad5)-transformed secondary rat embryo cells. Somatic cell hybrids were formed between a highly progressed neomycin-resistant Ad5-transformed clon...

journal_title：Molecular and cellular biology

authors： Duigou GJ,Babiss LE,Iman DS,Shay JW,Fisher PB

更新日期：1990-05-01 00:00:00

abstract：:We provide evidence that human SLFN5, an interferon (IFN)-inducible member of the Schlafen (SLFN) family of proteins, exhibits key roles in controlling motility and invasiveness of renal cell carcinoma (RCC) cells. Our studies define the mechanism by which this occurs, demonstrating that SLFN5 negatively controls expr...

journal_title：Molecular and cellular biology

authors： Sassano A,Mavrommatis E,Arslan AD,Kroczynska B,Beauchamp EM,Khuon S,Chew TL,Green KJ,Munshi HG,Verma AK,Platanias LC

更新日期：2015-08-01 00:00:00

abstract：:Treatment of K562 cells, a human erythroleukemia cell line, with desferrioxamine raised the levels of the receptor for transferrin (Tf) two- to threefold over that of the control cells. The levels of receptor were reduced by at least 50 and 35% of that of the control in cells treated with diferric Tf and ferric ammoni...

journal_title：Molecular and cellular biology

authors： Rao KK,Shapiro D,Mattia E,Bridges K,Klausner R

更新日期：1985-04-01 00:00:00

abstract：:Histone methylation at H3K4 and H3K36 is commonly associated with genes actively transcribed by RNA polymerase II (RNAPII) and is catalyzed by Saccharomyces cerevisiae Set1 and Set2, respectively. Here we report that both methyltransferases can be UV cross-linked to RNA in vivo High-throughput sequencing of the bound ...

journal_title：Molecular and cellular biology

authors： Sayou C,Millán-Zambrano G,Santos-Rosa H,Petfalski E,Robson S,Houseley J,Kouzarides T,Tollervey D

更新日期：2017-06-29 00:00:00

abstract：:Receptor tyrosine kinases (RTKs) play distinct roles in multiple biological systems. Many RTKs transmit similar signals, raising questions about how specificity is achieved. One potential mechanism for RTK specificity is control of the magnitude and kinetics of activation of downstream pathways. We have found that the...

journal_title：Molecular and cellular biology

authors： Zhang SQ,Tsiaras WG,Araki T,Wen G,Minichiello L,Klein R,Neel BG

更新日期：2002-06-01 00:00:00