Serum ghrelin is inversely associated with cognitive function in a sample of non-demented elderly.

Abstract:

AIM:The orexigenic hormone, ghrelin, is linked to learning and memory in animal studies. No previous study has investigated whether cognition is related to ghrelin in the non-demented elderly. METHODS:Thirty-five older adults underwent neuropsychological testing and fasting blood draw with subsequent serum ghrelin quantification. RESULTS:Ghrelin was negatively correlated with several cognitive domains, including verbal memory, working memory, and naming. CONCLUSION:Areas of cognition associated with ghrelin level were similar to the pattern of deficits observed in early Alzheimer's disease. Findings suggest a potential moderational role of ghrelin in pathological cognitive decline. Further work investigating mechanisms is needed.

authors

Spitznagel MB,Benitez A,Updegraff J,Potter V,Alexander T,Glickman E,Gunstad J

doi

10.1111/j.1440-1819.2010.02145.x

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

608-11

issue

6

eissn

1323-1316

issn

1440-1819

journal_volume

64

pub_type

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