Abstract:
:Maternal smoking during pregnancy is associated with increased risk of childhood overweight body mass index (BMI). Less is known about the association between prenatal secondhand tobacco smoke (SHS) exposure and childhood BMI. We followed 292 mother-child dyads from early pregnancy to 3 years of age. Prenatal tobacco smoke exposure during pregnancy was quantified using self-report and serum cotinine biomarkers. We used linear mixed models to estimate the association between tobacco smoke exposure and BMI at birth, 4 weeks, and 1, 2 and 3 years. During pregnancy, 15% of women reported SHS exposure and 12% reported active smoking, but 51% of women had cotinine levels consistent with SHS exposure and 10% had cotinine concentrations indicative of active smoking. After adjustment for confounders, children born to active smokers (self-report or serum cotinine) had higher BMI at 2 and 3 years of age, compared with unexposed children. Children born to women with prenatal serum cotinine concentrations indicative of SHS exposure had higher BMI at 2 (mean difference [MD] 0.3 [95% confidence interval -0.1, 0.7]) and 3 (MD 0.4 [0, 0.8]) years compared with unexposed children. Using self-reported prenatal exposure resulted in non-differential exposure misclassification of SHS exposures that attenuated the association between SHS exposure and BMI compared with serum cotinine concentrations. These findings suggest active and secondhand prenatal tobacco smoke exposure may be related to an important public health problem in childhood and later life. In addition, accurate quantification of prenatal secondhand tobacco smoke exposures is essential to obtaining valid estimates.
journal_name
Paediatr Perinat Epidemioljournal_title
Paediatric and perinatal epidemiologyauthors
Braun JM,Daniels JL,Poole C,Olshan AF,Hornung R,Bernert JT,Khoury J,Needham LL,Barr DB,Lanphear BPdoi
10.1111/j.1365-3016.2010.01146.xsubject
Has Abstractpub_date
2010-11-01 00:00:00pages
524-34issue
6eissn
0269-5022issn
1365-3016journal_volume
24pub_type
杂志文章abstract::In spite of technological progress throughout the world, ill health, both physical and mental, is widespread - but much of this is preventable. With rapid globalization, populations in both industrialised and developing countries are being exposed to various stresses and to new environmental factors, such as those rel...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
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journal_title:Paediatric and perinatal epidemiology
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更新日期:2002-01-01 00:00:00
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journal_title:Paediatric and perinatal epidemiology
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journal_title:Paediatric and perinatal epidemiology
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更新日期:2018-03-01 00:00:00
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journal_title:Paediatric and perinatal epidemiology
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doi:10.1111/j.1365-3016.1991.tb00699.x
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journal_title:Paediatric and perinatal epidemiology
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journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.1990.tb00628.x
更新日期:1990-04-01 00:00:00
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doi:10.1111/j.1365-3016.2010.01129.x
更新日期:2010-07-01 00:00:00
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journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.2006.00714.x
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journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.2010.01183.x
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pub_type: 杂志文章,评审
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更新日期:1994-07-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2001-07-01 00:00:00
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pub_type: 杂志文章
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journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
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更新日期:2014-11-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2014-03-01 00:00:00
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journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章,评审
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更新日期:1989-01-01 00:00:00
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journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
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更新日期:1994-01-01 00:00:00
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journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/ppe.12040
更新日期:2013-05-01 00:00:00
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journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.1991.tb00689.x
更新日期:1991-01-01 00:00:00