Abstract:
:Understanding the mechanisms that underlie successful human reproduction and development is an ambitious goal, given the many unique methodological challenges surrounding such study. These challenges are well understood by reproductive and perinatal epidemiologists and include its conditional nature, unobservable yet informative outcomes such as conception, multi-scale missing data, correlated or non-independent outcomes, interval censoring and a hierarchical data structure. Novel methodologies for overcoming these challenges and for answering critical data gaps are needed if we are to better understand the inefficiency that currently characterises human reproduction with the goal of improving population health. The exposome is an emerging paradigm that offers promise for understanding the natural history of human reproduction and development, and its many associated impairments that develop later in child- or adulthood. This novel paradigm recognises the need to identify and measure the totality of environmental (non-genetic) exposures from preconception through sensitive windows, and to identify patterns associated with healthy and adverse outcomes. The exposome accommodates research focusing on unique subpopulations, such as couples undergoing assisted reproductive technologies, so that methodological limitations such as unobservable and conditional outcomes can be better addressed. Reproductive and perinatal epidemiology is uniquely suited for proof-of-concept exposome research, given the intricate relations between fecundity, gravid health and later onset disease and the narrow and interrelated sensitive windows that characterise the conditional nature of human reproduction and development. Bold new conceptual frameworks such as the exposome are needed for designing research that may lead to discovery and improve population health.
journal_name
Paediatr Perinat Epidemioljournal_title
Paediatric and perinatal epidemiologyauthors
Buck Louis GM,Yeung E,Sundaram R,Laughon SK,Zhang Cdoi
10.1111/ppe.12040subject
Has Abstractpub_date
2013-05-01 00:00:00pages
229-36issue
3eissn
0269-5022issn
1365-3016journal_volume
27pub_type
杂志文章abstract:BACKGROUND:We evaluated the importance of measuring early vaginal levels of eight bacterial vaginosis (BV)-associated bacteria, at two points in pregnancy, and the risk of spontaneous preterm delivery (SPTD) among pregnant women and the subgroup of pregnant women with a history of preterm delivery (PTD). METHODS:This ...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1111/ppe.12106
更新日期:2014-03-01 00:00:00
abstract::This study describes the timing of puberty in 8- to 13-year-old girls enrolled in the Avon Longitudinal Study of Parents and Children (ALSPAC) and identifies factors associated with earlier achievement of menarche. Women were enrolled during pregnancy and their offspring were followed prospectively. We analysed self-r...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.2009.01055.x
更新日期:2009-09-01 00:00:00
abstract::In this study we have examined the early life predictors of smoking at age 14 in a birth cohort of individuals born in Brisbane, Australia between 1981 and 1984. In stratified and multivariable analyses maternal smoking throughout pregnancy and when the child was aged 14 were both associated with the child smoking: fu...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.2005.00674.x
更新日期:2005-09-01 00:00:00
abstract::Recurrence risk provides information on the heterogeneity of risk in the population, and thus is useful for aetiological studies. While recurrence risk is observable in many areas of epidemiology, it is particularly accessible in the study of perinatal events. High recurrence rates of pregnancy problems suggest geneti...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.2007.00830.x
更新日期:2007-07-01 00:00:00
abstract::We studied infant mortality rates in Canada within specific gestational age and birthweight categories after using probabilistic techniques to link information in Statistics Canada's live births data base (1985-94) with that in the death data base (1985-95). Gestational age- and birthweight-specific mortality rates in...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1046/j.1365-3016.2000.00298.x
更新日期:2000-10-01 00:00:00
abstract::Between 1988 and 1991, years of political and economic crisis, Bulgaria reported a 25% increase in infant mortality. From 1991 to 1995, the rate then dropped slightly. Analysis of detailed unpublished vital statistics shows that the reported increase could not have been a result of more complete reporting of early neo...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1046/j.1365-3016.2000.00242.x
更新日期:2000-04-01 00:00:00
abstract::Previous studies have suggested a relationship between reproductive history, pregnancy and birth factors, and the risk of neuroblastoma. We conducted a case-control telephone interview study that included a total of 504 children under the age of 19 years with newly diagnosed neuroblastoma identified by two national co...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1046/j.1365-3016.2001.0376a.x
更新日期:2001-10-01 00:00:00
abstract::There is still much debate as to the pathways through which some children develop asthma and others do not. One possible mechanism outlined here concerns the way in which stress may influence the neuroendocrine system and thence the immune system. Supporting evidence from animal experiments suggests that maternal pren...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.2007.00879.x
更新日期:2007-11-01 00:00:00
abstract::The incidence of neural tube defects was monitored among all live- and still-births delivered between June 1986 and July 1988. In all there were 19,115 total births. The incidence of neural tube defects (NTD) was 1.9 per 1000 among those whose conception time was prior to May 1986. However, in conceptions occurring in...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.1989.tb00370.x
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:To optimise the health of pregnant women and their children by evidence-based primary and secondary prevention, more scientific knowledge is needed. To overcome the methodological limitations of many studies on pregnancy and child health, which often use a retrospective design, we established the PRIDE (PReg...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/ppe.12023
更新日期:2013-01-01 00:00:00
abstract::Cognitively delayed children are at risk for poor mental and physical health throughout their lives. The economically disadvantaged and some race/ethnic groups are more likely to experience cognitive delay, but the age at which delays first emerge and the underlying mechanisms responsible for disparities are not well ...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.2008.01006.x
更新日期:2009-05-01 00:00:00
abstract::We estimated the accuracy of a non-invasive, inexpensive method (the Chinese lunar calendar, CLC) to predict the sex of a baby from around the time of conception, using 2,840,755 singleton births occurring in Sweden between 1973 and 2006. Maternal lunar age and month of conception were estimated, and used to predict e...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.2010.01129.x
更新日期:2010-07-01 00:00:00
abstract::Birthweight is associated with health outcomes throughout the lifespan. Official birthweight records are not always available, and researchers must rely on self-reports for birthweight information. This study evaluates the accuracy of adolescent self-reports of birthweight, using medical records as a standard, and com...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.2006.00757.x
更新日期:2006-11-01 00:00:00
abstract::There is adequate evidence that growth during the perinatal period is linked to the risk of several adult onset diseases, and recent findings indicate that the insulin-like growth factor (IGF) system is involved in prenatal growth, as reflected in birthweight. However, whether major components of the IGF system are in...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1046/j.1365-3016.2003.00494.x
更新日期:2003-07-01 00:00:00
abstract::Over the last decade, there has been growing concern about the possible health effects, including a number of adverse reproductive outcomes, from pesticide exposure of people living near agricultural fields. This systematic review evaluates the current epidemiological evidence on the association between living near ag...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-3016.2010.01165.x
更新日期:2011-03-01 00:00:00
abstract::We investigated time trends in maternal weight before and during pregnancy and in infant birthweight in France, from 1972 to 2003, using data on singleton live term births from the representative National Perinatal Surveys of 1972, 1981, 1995, 1998 and 2003 (n=8,664, 4,494, 11,445, 12,006, 12,692, respectively). Mothe...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.2010.01188.x
更新日期:2011-05-01 00:00:00
abstract::Development of the perineum as well as the external genitalia is determined by dihydrotestosterone, resulting in a greater anogenital distance (AGD) in males than females. In animal experiments with hormonally active agents, anogenital distance is used as a bioassay of fetal androgen action. Use of anogenital distance...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1365-3016.2007.00810.x
更新日期:2007-05-01 00:00:00
abstract::Otitis media is one of the most common infections of early childhood. Children who first experience acute otitis media at an early age (before 6 months) are at increased risk for recurrent otitis media. This prospective study investigated exposure to measured levels of airborne household mould and the risk of early ot...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1365-3016.2004.00596.x
更新日期:2004-11-01 00:00:00
abstract::Passive smoking during pregnancy leads to adverse effects on mother and infant. The present investigation was designed to evaluate the association between maternal reported passive smoking with the cotinine concentration of maternal urine and umbilical cord blood at delivery and to determine the accuracy of maternal r...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.2011.01242.x
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Studies using vital records-based maternal weight data have become more common, but the validity of these data is uncertain. METHODS:We evaluated the accuracy of prepregnancy body mass index (BMI) and gestational weight gain (GWG) reported on birth certificates using medical record data in 1204 births at a ...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/ppe.12120
更新日期:2014-05-01 00:00:00
abstract::We examined hospital and domestic infant care practices in Oxfordshire and Northampton Health Districts to measure changes in prevalence of sudden infant death syndrome (SIDS) risk factors, and to evaluate a specific educational intervention restricted to Oxfordshire. We sent a postal questionnaire to 2781 parents of ...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1046/j.1365-3016.1998.00089.x
更新日期:1998-04-01 00:00:00
abstract::Social differences in late fetal death and infant mortality were examined in a population-based prospective study. All singletons born to Nordic citizens in Sweden 1985-86 were included, 185,156 births in all. The overall rates of late fetal death and infant mortality were 3.5 and 5.3 per 1000 respectively. Socio-econ...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.1993.tb00599.x
更新日期:1993-01-01 00:00:00
abstract::This report describes a cohort study of over 5000 infants and their mothers who participated in a cord blood serosurvey designed to examine the relationship between maternal exposure to Lyme disease and adverse pregnancy outcome. Based on serology and reported clinical history, mothers of infants in an endemic hospita...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.1995.tb00148.x
更新日期:1995-07-01 00:00:00
abstract::A prospective study of 4934 babies of different ethnic groups has confirmed the high perinatal mortality rate for Pakistanis and has shown that this was not due to a reluctance to terminate a fetus who is known to be seriously malformed. The major cause of early mortality was a high rate of lethal malformations, which...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.1991.tb00689.x
更新日期:1991-01-01 00:00:00
abstract::The aims of the study were to describe the trend in birthweight from 1985 to 2000 in Chile and ascertain the possible factors that may explain the changes in birthweight during the period. We used time series of birthweight and length at birth of all live births (n > 4,000,000). Multivariable regression analyses were ...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.2005.00673.x
更新日期:2005-11-01 00:00:00
abstract::This study evaluated the diagnostic accuracy of a verbal autopsy (VA) tool in ascertaining the causes of stillbirths and neonatal deaths in rural Ghana and was nested within a community-based maternal vitamin A supplementation trial (ObaapaVitA trial). All stillbirths and neonatal deaths between 1 January 2003 and 30 ...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1365-3016.2008.00962.x
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:Self-reported weight prior to pregnancy is prone to error. We utilised a measured pre-conceptional weight from the electronic health record (EHR) to investigate error in recalled pre-pregnancy body mass index (BMI) category and compared how associations between pre-pregnancy BMI and pregnancy outcomes varied...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/ppe.12286
更新日期:2016-07-01 00:00:00
abstract::There has been a trend over the past two decades in some Western countries for women to delay childbearing, a factor associated with an increased risk of perinatal mortality (stillbirth and neonatal death). While the rates of stillbirth and neonatal mortality have improved in some countries, it has not been establishe...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.2007.00849.x
更新日期:2007-11-01 00:00:00
abstract::The fetal growth curve and neonatal mortality rate, based on gestational age and birthweight, are important for identifying groups of high-risk neonates and developing appropriate medical services and health-care programmes. The purpose of this study was to develop a national fetal growth curve for neonates in Korea, ...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章
doi:10.1111/j.1365-3016.2007.00850.x
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:Clinicians' interest in the long-term effects of early postnatal growth (EPG) is growing. There is compelling evidence linking rapid EPG with later cardiovascular risk, but its neurodevelopmental benefits still remain hypothetical in individuals born moderately preterm (MP) or small for gestational at term (...
journal_title:Paediatric and perinatal epidemiology
pub_type: 杂志文章,评审
doi:10.1111/ppe.12468
更新日期:2018-05-01 00:00:00