Abstract：
:This study reports changes in the prevalence and outcome of Down's syndrome pregnancies within a 15-year period in a defined geographical population in the north of England. Cases of Down's syndrome in births and terminations of pregnancy occurring between 1985 and 1999, were identified from the Northern Congenital Abnormality Survey. The total prevalence for the 15 years was 15.2 per 10 000 births and terminations of pregnancy [95% CI 14.2, 16.2]. Total prevalence showed an upward trend over time, due largely to increasing maternal age. Sixty-seven per cent of cases resulted in live births, and the overall live birth prevalence was 10.3 per 10 000 live births [95% CI 9.4, 11.1]. The proportion of cases resulting in termination of pregnancy rose from 15% in 1985-89 to 38% in 1995-99; the rate of increase was greater in women aged < 35 years. Forty-five per cent of live born infants had an additional anomaly recorded. Survival at 1 year was 78% for those with an additional anomaly recorded, and 96% for those without. There was a non-significant trend towards improved survival in all infants with Down's syndrome, from 87% in 1985-94 to 92% in 1995-99. Despite increasing termination of Down's syndrome pregnancies resulting from the greater availability of antenatal screening and diagnosis, there has been no significant reduction in live birth prevalence. These infants have high rates of co-existing structural anomalies and are at high risk of death in the first year of life. There is a continuing need to address the reasons for poor survival for Down's syndrome infants, and to plan for their complex health and social care needs. These findings are useful for parents deciding on prenatal screening, as well as for clinicians and health service managers.
journal_name
Paediatr Perinat Epidemioljournal_title
Paediatric and perinatal epidemiologyauthors
Bell R,Rankin J,Donaldson LJ,Northern Congenital Abnormality Survey Steering Group.doi
10.1046/j.1365-3016.2003.00463.xsubject
Has Abstractpub_date
2003-01-01 00:00:00pages
33-9issue
1eissn
0269-5022issn
1365-3016pii
463journal_volume
17pub_type
杂志文章abstract：BACKGROUND:Recent data suggest that early-term births are associated with later respiratory morbidity (LRTI), and post-term births may decrease this risk. OBJECTIVES:The objective was to determine the impact of early-term, late-term, and post-term birth on hospital admission for LRTI up to the age of seven years. Addi...
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pub_type： 杂志文章,评审
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更新日期：2001-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2010-07-01 00:00:00
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journal_title：Paediatric and perinatal epidemiology
pub_type： 杂志文章
doi：10.1111/j.1365-3016.1991.tb00699.x
更新日期：1991-04-01 00:00:00
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journal_title：Paediatric and perinatal epidemiology
pub_type： 杂志文章
doi：10.1111/j.1365-3016.1990.tb00655.x
更新日期：1990-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：1990-04-01 00:00:00
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更新日期：2009-11-01 00:00:00
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更新日期：2010-05-01 00:00:00
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更新日期：2009-03-01 00:00:00
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更新日期：2013-07-01 00:00:00
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