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Synthesis and biological evaluation of [D-lysine]8cyclosporin A analogs as potential anti-HCV agents.

Abstract：

:An efficient synthesis of [D-lysine](8)cyclosporin A has been developed. Several analogs of [D-lysine](8)cyclosporin A have been synthesized and show promising anti-HCV activity, particularly compounds 39 and 43, which each exhibit an anti-HCV EC(50)<200 nM, and are each ≥50-fold less immunosuppressive than cyclosporin A.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Scribner A,Houck D,Huang Z,Mosier S,Peel M,Scorneaux B

doi

10.1016/j.bmcl.2010.09.036

subject

Has Abstract

pub_date

2010-11-15 00:00:00

pages

6542-6

issue

22

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(10)01327-2

journal_volume

20

pub_type

杂志文章

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