Quantified neurophysiology with mapping: statistical inference, exploratory and confirmatory data analysis.

Abstract:

:Topographic mapping of brain electrical activity has become a commonly used method in the clinical as well as research laboratory. To enhance analytic power and accuracy, mapping applications often involve statistical paradigms for the detection of abnormality or difference. Because mapping studies involve many measurements and variables, the appearance of a large data dimensionality may be created. If abnormality is sought by statistical mapping procedures and if the many variables are uncorrelated, certain positive findings could be attributable to chance. To protect against this undesirable possibility we advocate the replication of initial findings on independent data sets. Statistical difference attributable to chance will not replicate, whereas real difference will reproduce. Clinical studies must, therefore, provide for repeat measurements and research studies must involve analysis of second populations. Furthermore, Principal Components Analysis can be employed to demonstrate that variables derived from mapping studies are highly intercorrelated and data dimensionality substantially less than the total number of variables initially created. This reduces the likelihood of capitalization on chance. The need to constrain alpha levels is not necessary when dimensionality is low and/or a second data set is available. When only one data set is available in research applications, techniques such as the Bonferroni correction, the "leave-one-out" method, and Descriptive Data Analysis (DDA) are available. These techniques are discussed, clinical and research examples are given, and differences between Exploratory (EDA) and Confirmatory Data Analysis (EDA) are reviewed.

journal_name

Brain Topogr

journal_title

Brain topography

authors

Duffy FH,Jones K,Bartels P,Albert M,McAnulty GB,Als H

doi

10.1007/BF01128856

subject

Has Abstract

pub_date

1990-10-01 00:00:00

pages

3-12

issue

1

eissn

0896-0267

issn

1573-6792

journal_volume

3

pub_type

杂志文章,评审
  • The usefulness of the Laplacian in principal component analysis and dipole source localization.

    abstract::Evoked potentials are difficult to analyze because multiple sources are active simultaneously. Principal component analysis and dipole localization are two techniques that have been used to disentangle overlapping sources. Both of these techniques have problems. Principal component analysis suffers from a rotation amb...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/BF01199773

    authors: Klein SA,Carney T

    更新日期:1995-01-01 00:00:00

  • Interaction Between Words and Symbolic Gestures as Revealed By N400.

    abstract::What happens if you see a person pronouncing the word "go" after having gestured "stop"? Differently from iconic gestures, that must necessarily be accompanied by verbal language in order to be unambiguously understood, symbolic gestures are so conventionalized that they can be effortlessly understood in the absence o...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-014-0392-4

    authors: Fabbri-Destro M,Avanzini P,De Stefani E,Innocenti A,Campi C,Gentilucci M

    更新日期:2015-07-01 00:00:00

  • Advantages and limitations of magnetic source imaging.

    abstract::The term "magnetic source image" (MSI) describes the distribution of neuronal activity in the brain that can be deduced from measurements of the field pattern it produces across the scalp. The signals which provide the basis for an MSI are obtained from the magnetoencephalogram (MEG) which is conventionally recorded w...

    journal_title:Brain topography

    pub_type: 杂志文章,评审

    doi:10.1007/BF01132773

    authors: Williamson SJ,Lü ZL,Karron D,Kaufman L

    更新日期:1991-01-01 00:00:00

  • Learning to associate auditory and visual stimuli: behavioral and neural mechanisms.

    abstract::The ability to effectively combine sensory inputs across modalities is vital for acquiring a unified percept of events. For example, watching a hammer hit a nail while simultaneously identifying the sound as originating from the event requires the ability to identify spatio-temporal congruencies and statistical regula...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-013-0333-7

    authors: Altieri N,Stevenson RA,Wallace MT,Wenger MJ

    更新日期:2015-05-01 00:00:00

  • Towards Using Microstate-Neurofeedback for the Treatment of Psychotic Symptoms in Schizophrenia. A Feasibility Study in Healthy Participants.

    abstract::Spontaneous EEG signal can be parsed into sub-second periods of stable functional states (microstates) that assumingly correspond to brief large scale synchronization events. In schizophrenia, a specific class of microstate (class "D") has been found to be shorter than in healthy controls and to be correlated with pos...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-015-0460-4

    authors: Diaz Hernandez L,Rieger K,Baenninger A,Brandeis D,Koenig T

    更新日期:2016-03-01 00:00:00

  • Neurophysiological Correlates of Attentional Fluctuation in Attention-Deficit/Hyperactivity Disorder.

    abstract::Cognitive performance in attention-deficit/hyperactivity disorder (ADHD) is characterised, in part, by frequent fluctuations in response speed, resulting in high reaction time variability (RTV). RTV captures a large proportion of the genetic risk in ADHD but, importantly, is malleable, improving significantly in a fas...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-017-0554-2

    authors: Cheung CHM,McLoughlin G,Brandeis D,Banaschewski T,Asherson P,Kuntsi J

    更新日期:2017-05-01 00:00:00

  • A four sphere model for calculating the magnetic field associated with spreading cortical depression.

    abstract::In our previous model, we ascertained that the large amplitude waves (LAWs), reported by Barkley and coworkers (1990) in time series magnetoencephalography (MEG) recordings from migraine patients, could be simulated and compared with the recorded signals using a simple plane volume conductor model (Tepley and Wijesing...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/BF01190388

    authors: Wijesinghe RS,Tepley N

    更新日期:1997-04-01 00:00:00

  • Neural Correlate of Anterograde Amnesia in Wernicke-Korsakoff Syndrome.

    abstract::The neural correlate of anterograde amnesia in Wernicke-Korsakoff syndrome (WKS) is still debated. While the capacity to learn new information has been associated with integrity of the medial temporal lobe (MTL), previous studies indicated that the WKS is associated with diencephalic lesions, mainly in the mammillary ...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-014-0391-5

    authors: Nahum L,Pignat JM,Bouzerda-Wahlen A,Gabriel D,Liverani MC,Lazeyras F,Ptak R,Richiardi J,Haller S,Thorens G,Zullino DF,Guggisberg AG,Schnider A

    更新日期:2015-09-01 00:00:00

  • Cerebral dynamics of SEPS to non-painful and painful cutaneous electrical stimulation of the thenar and hypothenar.

    abstract::Early, middle and late latency somatosensory evoked potentials (SEPs) elicited by cutaneous electrical stimulation (painful vs. non-painful) of right and left hands were recorded. The aims were to study (1) if lifelong use of dominant right hand would result in different SEP topographies compared to non-dominant left ...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1023/a:1026655001804

    authors: Niddam DM,Arendt-Nielsen L,Chen AC

    更新日期:2000-01-01 00:00:00

  • Saccade related gamma-band activity in intracerebral EEG: dissociating neural from ocular muscle activity.

    abstract::Recent evidence suggests that transient increases in scalp electroencephalography (EEG) gamma band power (above 30 Hz) can be due to miniature eye movements. Although, these findings do not raise doubts about the widely established role of gamma range neural synchrony, it does call for caution when it comes to interpr...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-009-0078-5

    authors: Jerbi K,Freyermuth S,Dalal S,Kahane P,Bertrand O,Berthoz A,Lachaux JP

    更新日期:2009-06-01 00:00:00

  • EEG Artifact Removal in TMS Studies of Cortical Speech Areas.

    abstract::The combination of transcranial magnetic stimulation (TMS) and electroencephalography (EEG) is commonly applied for studying the effective connectivity of neuronal circuits. The stimulation excites neurons, and the resulting TMS-evoked potentials (TEPs) are recorded with EEG. A serious obstacle in this method is the g...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-019-00724-w

    authors: Salo KS,Mutanen TP,Vaalto SMI,Ilmoniemi RJ

    更新日期:2020-01-01 00:00:00

  • Higher gait variability is associated with decreased parietal gray matter volume among healthy older adults.

    abstract::The objectives of this study were to examine the association of stride time variability (STV) with gray and white matter volumes in healthy older adults, and to determine the specific location of any parenchymal loss associated with higher STV. A total of 71 participants (mean age 69.0 ± 0.8 years; 59.7 % female) were...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-013-0293-y

    authors: Beauchet O,Annweiler C,Celle S,Bartha R,Barthélémy JC,Roche F

    更新日期:2014-03-01 00:00:00

  • Bridging the Gap Towards Awareness Detection in Disorders of Consciousness: An Experimental Study on the Mirror Neuron System.

    abstract::Advanced functional neuroimaging approaches dealing with motor imagery have disclosed covert cognitive processes in patients with disorders of consciousness (DoC). However, motor impairment and cognitive-motor dissociation can bias such approaches. Fourteen patients with post-traumatic DoC and ten healthy controls (HC...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-018-0628-9

    authors: Naro A,Calabrò RS,Leo A,Russo M,Milardi D,Cannavò A,Manuli A,Buda A,Casella C,Bramanti P,Cacciola A,Bramanti A

    更新日期:2018-07-01 00:00:00

  • Dynamics of brain activation during an explicit word and image recognition task: an electrophysiological study.

    abstract::Recent brain imaging studies suggest that semantic processing of words and images may share a common neural network, although modality-specific activation can also be observed. Other studies using event-related potentials (ERPs) report that brain responses to words and images may already differ at approximately 150 ms...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1023/a:1014502925003

    authors: Khateb A,Pegna AJ,Michel CM,Landis T,Annoni JM

    更新日期:2002-04-01 00:00:00

  • Change in Excitability of Corticospinal Pathway and GABA-Mediated Inhibitory Circuits of Primary Motor Cortex Induced by Contraction of Adjacent Hand Muscle.

    abstract::The present study examined whether the excitability of the corticospinal pathway and the GABA-mediated inhibitory circuits of the primary motor cortex that project onto the corticospinal neurons in the tonically contracting hand muscle are changed by tonic contraction of the adjacent hand muscle. The motor evoked pote...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-016-0499-x

    authors: Jono Y,Iwata Y,Mizusawa H,Hiraoka K

    更新日期:2016-11-01 00:00:00

  • MEG study of short-term plasticity following multiple digit frequency discrimination training in humans.

    abstract::We trained four right-handed male subjects to detect small changes in the frequency of 21 Hz electrical stimulation applied to digits 2+3+4 of the right hand for 4 hours. Before and after the training, we recorded magnetoencephalographic (MEG) signals when the stimulation was applied to digit 2-5 separately using a wh...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1023/b:brat.0000032858.36816.98

    authors: Liu L,Ioannides AA

    更新日期:2004-07-01 00:00:00

  • Global Brain Involvement in Posterior Cortical Atrophy: Multimodal MR Imaging Investigation.

    abstract::Posterior cortical atrophy (PCA), considered a visual variant of Alzheimer's disease, has similar pathological characteristics yet shows a selective visual manifestation with relative preservation of other cortical areas, at least at early stages of disease. Using a gamut of imaging methods, we aim to evaluate the glo...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-020-00788-z

    authors: Glick-Shames H,Keadan T,Backner Y,Bick A,Levin N

    更新日期:2020-09-01 00:00:00

  • Association of Concurrent fNIRS and EEG Signatures in Response to Auditory and Visual Stimuli.

    abstract::Functional near-infrared spectroscopy (fNIRS) has been proven reliable for investigation of low-level visual processing in both infants and adults. Similar investigation of fundamental auditory processes with fNIRS, however, remains only partially complete. Here we employed a systematic three-level validation approach...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-015-0424-8

    authors: Chen LC,Sandmann P,Thorne JD,Herrmann CS,Debener S

    更新日期:2015-09-01 00:00:00

  • Facial emotion modulates the neural mechanisms responsible for short interval time perception.

    abstract::Emotionally arousing events can distort our sense of time. We used mixed block/event-related fMRI design to establish the neural basis for this effect. Nineteen participants were asked to judge whether angry, happy and neutral facial expressions that varied in duration (from 400 to 1,600 ms) were closer in duration to...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-013-0350-6

    authors: Tipples J,Brattan V,Johnston P

    更新日期:2015-01-01 00:00:00

  • Single trial analysis of neurophysiological correlates of the recognition of complex objects and facial expressions of emotion.

    abstract::In an earlier experiment, we have used the BTi twin MAGNES system (2 x 37 channels) to record the evoked magnetic field from five healthy right-handed male volunteers using two tasks: visual recognition of complex objects including faces and facial expressions of emotion. We have repeated the experiment with one of th...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1023/a:1022258620435

    authors: Liu L,Ioannides AA,Streit M

    更新日期:1999-07-01 00:00:00

  • Hemodynamic and EEG Time-Courses During Unilateral Hand Movement in Patients with Cortical Myoclonus. An EEG-fMRI and EEG-TD-fNIRS Study.

    abstract::Multimodal human brain mapping has been proposed as an integrated approach capable of improving the recognition of the cortical correlates of specific neurological functions. We used simultaneous EEG-fMRI (functional magnetic resonance imaging) and EEG-TD-fNIRS (time domain functional near-infrared spectroscopy) recor...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-014-0402-6

    authors: Visani E,Canafoglia L,Gilioli I,Sebastiano DR,Contarino VE,Duran D,Panzica F,Cubeddu R,Contini D,Zucchelli L,Spinelli L,Caffini M,Molteni E,Bianchi AM,Cerutti S,Franceschetti S,Torricelli A

    更新日期:2015-11-01 00:00:00

  • Movement-Related Somatosensory Activity Is Altered in Patients with Multiple Sclerosis.

    abstract::During active movement the somatosensory cortical responses are often attenuated. This attenuation is referred to as movement-related sensory gating. It is well known that patients with multiple sclerosis (MS) have sensory processing deficits, and recent work has also suggested that these patients display impaired mot...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-018-0632-0

    authors: Arpin DJ,Gehringer JE,Wilson TW,Kurz MJ

    更新日期:2018-07-01 00:00:00

  • Assessing the effects of electroconvulsive therapy on cortical excitability by means of transcranial magnetic stimulation and electroencephalography.

    abstract::Electroconvulsive therapy (ECT) has significant short-term antidepressant effects on drug-resistant patients with severe major depression. Animal studies have demonstrated that electroconvulsive seizures produce potentiation-like synaptic remodeling in both sub-cortical and frontal cortical circuits. However, the elec...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-012-0256-8

    authors: Casarotto S,Canali P,Rosanova M,Pigorini A,Fecchio M,Mariotti M,Lucca A,Colombo C,Benedetti F,Massimini M

    更新日期:2013-04-01 00:00:00

  • Measures of spatial similarity and response magnitude in MEG and scalp EEG.

    abstract::Sensor selection is typically used in magnetoencephalography (MEG) and scalp electroencephalography (EEG) studies, but this practice cannot differentiate between changes in the distribution of neural sources versus changes in the magnitude of neural sources. This problem is further complicated by (1) subject averaging...

    journal_title:Brain topography

    pub_type: 杂志文章,评审

    doi:10.1007/s10548-007-0040-3

    authors: Tian X,Huber DE

    更新日期:2008-04-01 00:00:00

  • Multiple equivalent current dipole source localization of visual event-related potentials during oddball paradigm with motor response.

    abstract::Event-related potentials (ERPs) during a visual oddball paradigm with button-pressing responses were recorded in 12 right-handed subjects from 32 scalp electrodes. The single equivalent current dipole (ECD) of the target C1 (weak occipito-parietal negativity from 30-80 ms) was consistently located at the primary visua...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1023/a:1023467806268

    authors: Yamazaki T,Kamijo K,Kenmochi A,Fukuzumi S,Kiyuna T,Takaki Y,Kuroiwa Y

    更新日期:2000-04-01 00:00:00

  • The normal scalp topography of the middle latency auditory evoked potential Pa component following monaural click stimulation.

    abstract::The scalp topography of the middle latency auditory evoked potential (MLAEP) Pa component following left and right ear click stimulation was investigated in 15 normal hearing and neurologically intact right-handed subjects. An unbiased reference was employed. The Pa component showed a broad voltage field that was reco...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/BF01129337

    authors: Jacobson GP,Grayson AS

    更新日期:1988-10-01 00:00:00

  • Grey Matter Volumes in the Executive Attention System Predict Individual Differences in Effortful Control in Young Adults.

    abstract::Effortful control (EC), considered as one component of temperament, describes an individual's capacity for self-regulation. Previous neuroimaging studies have provided convergent evidence that individual differences in EC are determined by the functioning of neural systems subserving executive attention, primarily com...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-018-0676-1

    authors: Wei L,Guo N,Baeken C,Bi M,Wang X,Qiu J,Wu GR

    更新日期:2019-01-01 00:00:00

  • Similarities between simulated spatial spectra of scalp EEG, MEG and structural MRI.

    abstract::Electrical dipoles oriented perpendicular to the cortical surface are the primary source of the scalp EEGs and MEGs. Thus, in particular, gyri and sulci structures on the cortical surface have a definite possibility to influence the EEGs and MEGs. This was examined by comparing the spatial power spectral density (PSD)...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-009-0104-7

    authors: Ramon C,Freeman WJ,Holmes M,Ishimaru A,Haueisen J,Schimpf PH,Rezvanian E

    更新日期:2009-11-01 00:00:00

  • Influence of a silastic ECoG grid on EEG/ECoG based source analysis.

    abstract::The simultaneous evaluation of the local electrocorticogram (ECoG) and the more broadly distributed electroencephalogram (EEG) from humans undergoing evaluation for epilepsy surgery has been shown to further the understanding of how pathologies give rise to spontaneous seizures. However, a well-known problem is that t...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-012-0251-0

    authors: Lanfer B,Röer C,Scherg M,Rampp S,Kellinghaus C,Wolters C

    更新日期:2013-04-01 00:00:00

  • Behavioral and Health Correlates of Resting-State Metastability in the Human Connectome Project.

    abstract::Metastability is currently considered a fundamental property of the functional configuration of brain networks. The present study sought to generate a normative reference framework for the metastability of the major resting-state networks (RSNs) (resting-state metastability dataset) and discover their association with...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-018-0672-5

    authors: Lee WH,Moser DA,Ing A,Doucet GE,Frangou S

    更新日期:2019-01-01 00:00:00