Abstract:
:During active movement the somatosensory cortical responses are often attenuated. This attenuation is referred to as movement-related sensory gating. It is well known that patients with multiple sclerosis (MS) have sensory processing deficits, and recent work has also suggested that these patients display impaired motor control of the ankle musculature. The primary goal of the current study was to: (1) examine the movement-related somatosensory gating in patients with MS and demographically-matched controls, and (2) identify the relationship between the sensory gating and motor control of the ankle musculature. To this end, we used magnetoencephalography brain imaging to assess the neural responses to a tibial nerve electrical stimulation that was applied at rest (passive) and during an ankle plantarflexion motor task (active condition). All participants also completed an ankle isometric motor control task that was performed outside the scanner. Our results indicated that the controls, but not patients with MS, exhibited significantly reduced somatosensory responses during the active relative to passive conditions, and that patients with MS had stronger responses compared with controls during the active condition. Additionally, control of the ankle musculature was related to the extent of movement-related sensory attenuation, with poor motor control being associated with reduced gating. Overall, these results show that patients with MS do not attenuate the somatosensory cortical activity during motor actions, and that the inability to modulate somatosensory cortical activity is partially related to the poor ankle motor control seen in these patients.
journal_name
Brain Topogrjournal_title
Brain topographyauthors
Arpin DJ,Gehringer JE,Wilson TW,Kurz MJdoi
10.1007/s10548-018-0632-0subject
Has Abstractpub_date
2018-07-01 00:00:00pages
700-707issue
4eissn
0896-0267issn
1573-6792pii
10.1007/s10548-018-0632-0journal_volume
31pub_type
杂志文章相关文献
BRAIN TOPOGRAPHY文献大全abstract::The use of tracers is an important technique available for studying cerebral function. Changes in 'signal' are large, but as a result of its photon limited nature, the measurement of this signal is limited: spatially, temporally and in terms of accuracy. The most commonly used single photon (SPECT) system (as apposed ...
journal_title:Brain topography
pub_type: 杂志文章,评审
doi:10.1007/BF01129039
更新日期:1992-01-01 00:00:00
abstract::In the past decade, the possibility of combining recordings of EEG and functional MRI (EEG-fMRI), has brought a new insight into the brain network underlying generalized spike wave discharges (GSWD). Nevertheless, how GSWD duration influences this network is not fully understood. In this study we aim to investigate wh...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/s10548-013-0311-0
更新日期:2014-01-01 00:00:00
abstract::Accurate source localization of electroencephalographic (EEG) signals requires detailed information about the geometry and physical properties of head tissues. Indeed, these strongly influence the propagation of neural activity from the brain to the sensors. Finite difference methods (FDMs) are head modelling approach...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/s10548-018-0683-2
更新日期:2019-03-01 00:00:00
abstract::The topography of the visual evoked magnetic response (VEMR) to pattern reversal stimulation was studied in four normal subjects using a single channel BTI magnetometer. VEMRs were recorded from 20 locations over the occipital scalp and the topographic distribution of the most consistent component (P100M) studied. A s...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/BF01129665
更新日期:1991-10-01 00:00:00
abstract::The combination of transcranial magnetic stimulation (TMS) with simultaneous electroencephalography (EEG) provides us the possibility to non-invasively probe the brain's excitability, time-resolved connectivity and instantaneous state. Early attempts to combine TMS and EEG suffered from the huge electromagnetic artifa...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/s10548-009-0123-4
更新日期:2010-01-01 00:00:00
abstract::Cognitive performance in attention-deficit/hyperactivity disorder (ADHD) is characterised, in part, by frequent fluctuations in response speed, resulting in high reaction time variability (RTV). RTV captures a large proportion of the genetic risk in ADHD but, importantly, is malleable, improving significantly in a fas...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/s10548-017-0554-2
更新日期:2017-05-01 00:00:00
abstract::Spatial principal components analysis (SPCA) applied to the ongoing EEG yields factor loadings which, when mapped, consistently reveal symmetrical patterns resembling the spherical harmonics. In this paper, we consider the mechanisms responsible for these characteristic patterns. In doing so, we demonstrate that volum...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/BF01135564
更新日期:1992-07-01 00:00:00
abstract::This paper describes a set of proposed standardized quantitative descriptors of event-related potentials, based upon principal component varimax analysis (PCVA). No claim is made that these mathematical descriptors correspond to discrete neurophysiological processes which generate the ERP. However, adoption and prospe...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/BF01191080
更新日期:1993-01-01 00:00:00
abstract::Reaction time (RT), the most common measure of CNS efficiency, shows intra- and inter-individual variability. This may be accounted for by hemispheric specialization, individual neuroanatomy, and transient functional fluctuations between trials. To explore RT on these three levels, ERPs were measured in a visual 4-cho...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/s10548-016-0473-7
更新日期:2016-07-01 00:00:00
abstract::Aging and sensorineural hearing loss are known to be involved in the development of chronic tinnitus. This study explores the structural changes of gray matter using surface base methods and focuses more specifically on changes in cortical thickness in 127 tinnitus patients. The linear relationships between cortical t...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/s10548-016-0511-5
更新日期:2016-11-01 00:00:00
abstract::The rationale for the present study was to investigate several aspects of P300 topography in relation to aging and neuropsychological measures. We administered an auditory oddball ERP task to 72 participants aged 21.8 to 94.7 years, 36 males and 36 females, in addition to the Wechsler Abbreviated Scales of Intelligenc...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1023/a:1012563605837
更新日期:2001-10-01 00:00:00
abstract::This study examined the effect of modality of stimulation on two measures of cerebral function: (a) the scalp distribution of sensory evoked potentials and (b) the cerebral distribution of radiolabelled HMPAO. Steady-state stimulation in the auditory, somatosensory or visual modality was presented to six subjects. Sca...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/BF01128854
更新日期:1989-10-01 00:00:00
abstract::The aim of this work was to use probabilistic diffusion tractography to examine the organization of the human insular cortex based on the similarities of its remote projections. Forty right-handed healthy subjects (33.8 ± 12.7 years old) with no history of neurological injury were included in the study. After the spat...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/s10548-011-0205-y
更新日期:2012-07-01 00:00:00
abstract::A visual three-stimulus (target, nontarget, standard) paradigm was employed in which subjects responded only to the target. Nontarget stimulus properties were varied systematically to evaluate how stimulus typicality (non-novel vs. novel) across task discrimination (easy vs. difficult) conditions affects P3a scalp top...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1023/a:1022637732495
更新日期:2003-04-01 00:00:00
abstract::Recent evidence suggests that type 2 diabetes (T2D) is associated with accelerated brain ageing, consistent with the observation of increased risk of cognitive impairment and dementia in affected individuals. Even non-diabetic individuals with impaired fasting plasma glucose (IFG) levels have shown increased cerebral ...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/s10548-017-0544-4
更新日期:2017-05-01 00:00:00
abstract::Automated structural magnetic resonance imaging (MRI) processing pipelines are gaining popularity for Alzheimer's disease (AD) research. They generate regional volumes, cortical thickness measures and other measures, which can be used as input for multivariate analysis. It is not clear which combination of measures an...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/s10548-012-0246-x
更新日期:2013-01-01 00:00:00
abstract::The combination of frequency-tagging with electroencephalography (EEG) has recently proved fruitful for understanding the perception of beat and meter in musical rhythm, a common behavior shared by humans of all cultures. EEG frequency-tagging allows the objective measurement of input-output transforms to investigate ...
journal_title:Brain topography
pub_type: 杂志文章,评审
doi:10.1007/s10548-017-0605-8
更新日期:2018-03-01 00:00:00
abstract::Metastability is currently considered a fundamental property of the functional configuration of brain networks. The present study sought to generate a normative reference framework for the metastability of the major resting-state networks (RSNs) (resting-state metastability dataset) and discover their association with...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/s10548-018-0672-5
更新日期:2019-01-01 00:00:00
abstract::The attentional blink (AB) is a transient attentional deficit that occurs when two stimuli that must both be detected are presented within an interval of less than 500 ms. Event-related potential (ERP) investigations have suggested that the AB affects a specific component, the P3, which is suppressed when targets are ...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/s10548-011-0199-5
更新日期:2012-04-01 00:00:00
abstract::EEG-signals were recorded from subjects as they performed a modified version of Schneider's and Shiffrin's memory search paradigm. The hypothesis was tested whether individual (centre of gravity) alpha frequency, termed IAF, is related to memory performance and/or attentional demands. The results show that memory perf...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/BF01128991
更新日期:1993-04-01 00:00:00
abstract::Previous independent EEG and PET studies suggest that administration of intravenous procaine hydrochloride selectively activates limbic brain structures. To further elucidate procaine's effects and explore the relationship between quantitative EEG (qEEG) and regional cerebral blood flow (rCBF), we simultaneously recor...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/BF01202380
更新日期:1995-04-01 00:00:00
abstract::We trained four right-handed male subjects to detect small changes in the frequency of 21 Hz electrical stimulation applied to digits 2+3+4 of the right hand for 4 hours. Before and after the training, we recorded magnetoencephalographic (MEG) signals when the stimulation was applied to digit 2-5 separately using a wh...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1023/b:brat.0000032858.36816.98
更新日期:2004-07-01 00:00:00
abstract::Spontaneous EEG signal can be parsed into sub-second periods of stable functional states (microstates) that assumingly correspond to brief large scale synchronization events. In schizophrenia, a specific class of microstate (class "D") has been found to be shorter than in healthy controls and to be correlated with pos...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/s10548-015-0460-4
更新日期:2016-03-01 00:00:00
abstract::The term "magnetic source image" (MSI) describes the distribution of neuronal activity in the brain that can be deduced from measurements of the field pattern it produces across the scalp. The signals which provide the basis for an MSI are obtained from the magnetoencephalogram (MEG) which is conventionally recorded w...
journal_title:Brain topography
pub_type: 杂志文章,评审
doi:10.1007/BF01132773
更新日期:1991-01-01 00:00:00
abstract::In 148 patients with focal cerebral lesions the findings of EEG mapping, routine EEG and CT were compared. Regarding etiology 43 patients suffered from completed stroke (CS), 43 patients from transient ischemic attack (TIA), 33 patients had an intracerebral hemorrhage (ICH) and 29 an hemispheric tumor. In 37 patients ...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/BF01129003
更新日期:1991-07-01 00:00:00
abstract::A new residual function in the inverse problem of equivalent dipole localization methods is proposed which is based on the spatial correlation of the background EEG. This residual has the advantage that it allows the calculation of confidence limits for dipole model parameters. The method was applied to VEP data, and ...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/BF01129050
更新日期:1992-01-01 00:00:00
abstract::The simultaneous evaluation of the local electrocorticogram (ECoG) and the more broadly distributed electroencephalogram (EEG) from humans undergoing evaluation for epilepsy surgery has been shown to further the understanding of how pathologies give rise to spontaneous seizures. However, a well-known problem is that t...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/s10548-012-0251-0
更新日期:2013-04-01 00:00:00
abstract::Multisensory processes include the capacity to combine information from the different senses, often improving stimulus representations and behavior. The extent to which multisensory processes are an innate capacity or instead require experience with environmental stimuli remains debated. We addressed this knowledge ga...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/s10548-020-00791-4
更新日期:2020-09-01 00:00:00
abstract::The subcortical connectivity underlying verbal perseveration (VP) remains poorly understood. We have previously reported that intraoperative electrical stimulation of the caudate nucleus during awake surgery resulted in VP. Here, our purpose is to study the white matter pathway underlying VP using subcortical stimulat...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/s10548-013-0343-5
更新日期:2014-05-01 00:00:00
abstract::The objectives of this study were to examine the association of stride time variability (STV) with gray and white matter volumes in healthy older adults, and to determine the specific location of any parenchymal loss associated with higher STV. A total of 71 participants (mean age 69.0 ± 0.8 years; 59.7 % female) were...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/s10548-013-0293-y
更新日期:2014-03-01 00:00:00