Abstract:
:Electroconvulsive therapy (ECT) has significant short-term antidepressant effects on drug-resistant patients with severe major depression. Animal studies have demonstrated that electroconvulsive seizures produce potentiation-like synaptic remodeling in both sub-cortical and frontal cortical circuits. However, the electrophysiological effects of ECT in the human brain are not known. In this work, we evaluated whether ECT induces a measurable change in the excitability of frontal cortical circuits in humans. Electroencephalographic (EEG) potentials evoked by transcranial magnetic stimulation (TMS) were collected before and after a course of ECT in eight patients with severe major depression. Cortical excitability was measured from the early and local EEG response to TMS. Clinical assessment confirmed the beneficial effects of ECT on depressive symptoms at the group level. TMS/EEG measurements revealed a clear-cut increase of frontal cortical excitability after ECT as compared to baseline, that was significant in each and every patient. The present findings corroborate in humans the idea that ECT may produce synaptic potentiation, as previously observed in animal studies. Moreover, results suggest that TMS/EEG may be employed in depressed patients to monitor longitudinally the electrophysiological effects of different therapeutic neuromodulators, e.g. ECT, repetitive TMS, and sleep deprivation. To the extent that depression involves an alteration of frontal cortical excitability, these measurements may be used to guide and evaluate treatment progression over time at the single-patient level.
journal_name
Brain Topogrjournal_title
Brain topographyauthors
Casarotto S,Canali P,Rosanova M,Pigorini A,Fecchio M,Mariotti M,Lucca A,Colombo C,Benedetti F,Massimini Mdoi
10.1007/s10548-012-0256-8subject
Has Abstractpub_date
2013-04-01 00:00:00pages
326-37issue
2eissn
0896-0267issn
1573-6792journal_volume
26pub_type
杂志文章相关文献
BRAIN TOPOGRAPHY文献大全abstract::A new residual function in the inverse problem of equivalent dipole localization methods is proposed which is based on the spatial correlation of the background EEG. This residual has the advantage that it allows the calculation of confidence limits for dipole model parameters. The method was applied to VEP data, and ...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/BF01129050
更新日期:1992-01-01 00:00:00
abstract::Recently, exploring brain activity based on functional networks during naturalistic stimuli especially music and video represents an attractive challenge because of the low signal-to-noise ratio in collected brain data. Although most efforts focusing on exploring the listening brain have been made through functional m...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/s10548-020-00758-5
更新日期:2020-05-01 00:00:00
abstract::Effortful control (EC), considered as one component of temperament, describes an individual's capacity for self-regulation. Previous neuroimaging studies have provided convergent evidence that individual differences in EC are determined by the functioning of neural systems subserving executive attention, primarily com...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/s10548-018-0676-1
更新日期:2019-01-01 00:00:00
abstract::A single flash accompanied by two auditory beeps tends to be perceived as two flashes (Shams et al. Nature 408:788, 2000, Cogn Brain Res 14:147-152, 2002). This phenomenon is known as 'sound-induced flash illusion.' Previous neuroimaging studies have shown that this illusion is correlated with modulation of activity i...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/s10548-009-0090-9
更新日期:2009-05-01 00:00:00
abstract::EEG reveals brain functions with high temporal resolution. Yet, multiple implicit variables may be involved in limited ERP measures. Special computation techniques are needed to recover these parameters. In the study of attention, we can obtain the ERP in attended (V) and unattended (U) conditions. Usually, the effect...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1023/a:1025662500837
更新日期:2003-10-01 00:00:00
abstract::Muscle or electromyogenic (EMG) artifact poses a serious risk to inferential validity for any electroencephalography (EEG) investigation in the frequency-domain owing to its high amplitude, broad spectrum, and sensitivity to psychological processes of interest. Even weak EMG is detectable across the scalp in frequenci...
journal_title:Brain topography
pub_type: 杂志文章,评审
doi:10.1007/s10548-009-0079-4
更新日期:2009-06-01 00:00:00
abstract::The rationale for the present study was to investigate several aspects of P300 topography in relation to aging and neuropsychological measures. We administered an auditory oddball ERP task to 72 participants aged 21.8 to 94.7 years, 36 males and 36 females, in addition to the Wechsler Abbreviated Scales of Intelligenc...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1023/a:1012563605837
更新日期:2001-10-01 00:00:00
abstract::Over the last 20 years, a body of techniques known as high resolution EEG has allowed precise estimation of cortical activity from non-invasive EEG measurements. The availability of cortical waveforms from non-invasive EEG recordings allows to have not only the level of activation within a single region of interest (R...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/s10548-007-0019-0
更新日期:2007-04-01 00:00:00
abstract::Facilitation and inhibition of return (IOR) are, respectively, faster and slower responses to a peripherally cued target. In a spatially uninformative peripheral cueing task, facilitation is normally observed when the interval between the cue and target stimulus, the stimulus onset asynchrony (SOA), is shorter than 25...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/s10548-011-0172-3
更新日期:2011-06-01 00:00:00
abstract::The subcortical connectivity underlying verbal perseveration (VP) remains poorly understood. We have previously reported that intraoperative electrical stimulation of the caudate nucleus during awake surgery resulted in VP. Here, our purpose is to study the white matter pathway underlying VP using subcortical stimulat...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/s10548-013-0343-5
更新日期:2014-05-01 00:00:00
abstract::Recent brain imaging studies suggest that semantic processing of words and images may share a common neural network, although modality-specific activation can also be observed. Other studies using event-related potentials (ERPs) report that brain responses to words and images may already differ at approximately 150 ms...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1023/a:1014502925003
更新日期:2002-04-01 00:00:00
abstract::The combination of transcranial magnetic stimulation (TMS) with simultaneous electroencephalography (EEG) provides us the possibility to non-invasively probe the brain's excitability, time-resolved connectivity and instantaneous state. Early attempts to combine TMS and EEG suffered from the huge electromagnetic artifa...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/s10548-009-0123-4
更新日期:2010-01-01 00:00:00
abstract::The event-related responses of 18 individuals were recorded while they were listening to 3 music clips of 6 s duration which were repeated 30 times each. The music clips differed in the level of their complex structure, induced mood, musical tempo and prominent frequency. They were taken from Mozart's sonata (K. 448),...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1023/b:brat.0000006331.10425.4b
更新日期:2003-01-01 00:00:00
abstract::Early, middle and late latency somatosensory evoked potentials (SEPs) elicited by cutaneous electrical stimulation (painful vs. non-painful) of right and left hands were recorded. The aims were to study (1) if lifelong use of dominant right hand would result in different SEP topographies compared to non-dominant left ...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1023/a:1026655001804
更新日期:2000-01-01 00:00:00
abstract::Reaction time (RT), the most common measure of CNS efficiency, shows intra- and inter-individual variability. This may be accounted for by hemispheric specialization, individual neuroanatomy, and transient functional fluctuations between trials. To explore RT on these three levels, ERPs were measured in a visual 4-cho...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/s10548-016-0473-7
更新日期:2016-07-01 00:00:00
abstract::The growing interest in brain networks to study the brain's function in cognition and diseases has produced an increase in methods to extract these networks. Typically, each method yields a different network. Therefore, one may ask what the resulting networks represent. To address this issue we consider electrocortico...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/s10548-018-0692-1
更新日期:2019-05-01 00:00:00
abstract::In an earlier experiment, we have used the BTi twin MAGNES system (2 x 37 channels) to record the evoked magnetic field from five healthy right-handed male volunteers using two tasks: visual recognition of complex objects including faces and facial expressions of emotion. We have repeated the experiment with one of th...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1023/a:1022258620435
更新日期:1999-07-01 00:00:00
abstract::Temporal structure is ubiquitous in sensory signals, and the brain has been shown to robustly represent information about temporal structure in the phase of low frequency neural oscillations. In a related construct, the integration of information across the different senses has been proposed to be at least partly due ...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/s10548-017-0560-4
更新日期:2017-09-01 00:00:00
abstract::Over the last decade, there has been growing interest in aberrant salience as a precursor of positive symptoms in schizophrenia. The present study investigates the neurophysiology of attentional capture by salient stimuli in the visual modality. Evoked oscillatory activity in the gamma frequency range (40 Hz) was asse...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/s10548-014-0418-y
更新日期:2015-01-01 00:00:00
abstract::We trained four right-handed male subjects to detect small changes in the frequency of 21 Hz electrical stimulation applied to digits 2+3+4 of the right hand for 4 hours. Before and after the training, we recorded magnetoencephalographic (MEG) signals when the stimulation was applied to digit 2-5 separately using a wh...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1023/b:brat.0000032858.36816.98
更新日期:2004-07-01 00:00:00
abstract::The altered functional connectivity in the brain of patients with early vascular dementia (VaD) is poorly understood. Here we investigated the directed connectivity differences between VaD and normal elderly while performing a visual oddball task. Multichannel EEG data during a visual oddball task were recorded for 12...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/s10548-014-0385-3
更新日期:2015-03-01 00:00:00
abstract::Despite genetic, morphological and experimental in vivo, data implying fixed abnormalities in patients with absence seizures, attempts to find highly consistent features in the 3-Hz spike-and-wave pattern recorded during sequential seizures from the same subject have been largely unsuccessful. We used a new data decom...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1023/a:1023462211778
更新日期:1999-01-01 00:00:00
abstract::The aim of this work was to use probabilistic diffusion tractography to examine the organization of the human insular cortex based on the similarities of its remote projections. Forty right-handed healthy subjects (33.8 ± 12.7 years old) with no history of neurological injury were included in the study. After the spat...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/s10548-011-0205-y
更新日期:2012-07-01 00:00:00
abstract::Spontaneous EEG signal can be parsed into sub-second periods of stable functional states (microstates) that assumingly correspond to brief large scale synchronization events. In schizophrenia, a specific class of microstate (class "D") has been found to be shorter than in healthy controls and to be correlated with pos...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/s10548-015-0460-4
更新日期:2016-03-01 00:00:00
abstract::Adaptive behaviour requires an ability to obtain rewards by choosing between different risky options. Financial gambles can be used to study effective decision-making experimentally, and to distinguish processes involved in choice option evaluation from outcome feedback and other contextual factors. Here, we used a pa...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/s10548-011-0210-1
更新日期:2012-01-01 00:00:00
abstract::In the past decade, the possibility of combining recordings of EEG and functional MRI (EEG-fMRI), has brought a new insight into the brain network underlying generalized spike wave discharges (GSWD). Nevertheless, how GSWD duration influences this network is not fully understood. In this study we aim to investigate wh...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/s10548-013-0311-0
更新日期:2014-01-01 00:00:00
abstract::Understanding the neural mechanisms of disorders of consciousness (DOC) is essential for estimating the conscious level and diagnosing DOC patients. Although previous studies reported brain functional connectivity (FC) and spontaneous neural activity patterns associated with consciousness, the relationship between the...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/s10548-018-0693-0
更新日期:2019-05-01 00:00:00
abstract::It is well known that, following an early visual deprivation, the neural network involved in processing auditory spatial information undergoes a profound reorganization. In particular, several studies have demonstrated an extensive activation of occipital brain areas, usually regarded as essentially "visual", when ear...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/s10548-009-0075-8
更新日期:2009-05-01 00:00:00
abstract::The functional organization of cortical speech processing is thought to be hierarchical, increasing in complexity and proceeding from primary sensory areas centrifugally. The current study used the mismatch negativity (MMN) obtained with electrophysiology (EEG) to investigate the early latency period of visual speech ...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/s10548-009-0094-5
更新日期:2009-05-01 00:00:00
abstract::Most EEG studies analysing speech production with event related brain potential (ERP) have adopted silent metalinguistic tasks or delayed or tacit picture naming in order to avoid possible artefacts during motor preparation. A central issue in the interpretation of these results is whether the processes involved in th...
journal_title:Brain topography
pub_type: 杂志文章
doi:10.1007/s10548-010-0162-x
更新日期:2011-03-01 00:00:00