Abstract：
:Oral-facial-digital type I (OFDI) syndrome is an X-linked male lethal developmental disorder. It is ascribed to ciliary dysfunction and characterized by malformation of the face, oral cavity, and digits. Conditional inactivation using different Cre lines allowed us to study the role of the Ofd1 transcript in limb development. Immunofluorescence and ultrastructural studies showed that Ofd1 is necessary for correct ciliogenesis in the limb bud but not for cilia outgrowth, in contrast to what was previously shown for the embryonic node. Mutants with mesenchymal Ofd1 inactivation display severe polydactyly with loss of antero-posterior (A/P) digit patterning and shortened long bones. Loss of digit identity was found to be associated with a progressive loss of Shh signaling and an impaired processing of Gli3, whereas defects in limb outgrowth were due to defective Ihh signaling and to mineralization defects during endochondral bone formation. Our data demonstrate that Ofd1 plays a role in regulating digit number and identity during limb and skeletal patterning increasing insight on the functional role of primary cilia during development.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Bimonte S,De Angelis A,Quagliata L,Giusti F,Tammaro R,Dallai R,Ascenzi MG,Diez-Roux G,Franco Bdoi
10.1016/j.ydbio.2010.09.020subject
Has Abstractpub_date
2011-01-15 00:00:00pages
179-91issue
2eissn
0012-1606issn
1095-564Xpii
S0012-1606(10)01098-5journal_volume
349pub_type
杂志文章abstract：:The source of neurite outgrowth in explant cultures of normal adult Apteronotus spinal cord was examined. Explants which contained the central region of spinal cord, including ependyma, showed neurite outgrowth in culture. Explants which did not contain ependyma showed no neurite outgrowth. It is concluded that the ep...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(87)90062-5
更新日期：1987-02-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：2015-10-01 00:00:00
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journal_title：Developmental biology
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更新日期：2006-03-01 00:00:00
abstract：:The myelin of the peripheral nervous system from the shiverer mutant mice is characterized by the absence of myelin basic protein, while the other myelin protein components are present at normal levels. Myelin lamella formation is normal in the shiverer mutant. Therefore, by using antiserum against myelin basic protei...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(84)90277-x
更新日期：1984-09-01 00:00:00
abstract：:From July 19-24, 2015, 169 clinicians and basic scientists gathered in the vertiginous heights of Snowmass, Colorado (2502 m) for the fourth FASEB summer research conference on the 'Biology of Cilia and Flagella'. Organizers Maureen Barr (Rutgers University), Iain Drummond (Massachusetts General Hospital/Harvard Medic...
journal_title：Developmental biology
pub_type：
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更新日期：2016-01-15 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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abstract：:There has been a resurgence of interest in comparative embryology. It is now important to be able to compare gene expression in different species at similar developmental stages. One phenomenon which may make it difficult to compare embryos in this way is heterochrony--a change in developmental timing during evolution...
journal_title：Developmental biology
pub_type： 杂志文章,评审
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更新日期：1995-12-01 00:00:00
abstract：:Previous work has documented the importance of BMPs in eye development. Loss-of-function studies in mice, with targeted deletions in either the Bmp7 or Bmp4 genes, have shown that these molecules are critical for early eye development. On the basis of the asymmetry in the dorsal-ventral expression patterns of several ...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/s0012-1606(02)00115-x
更新日期：2003-04-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2007.03.018
更新日期：2007-06-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：1989-11-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(84)90026-5
更新日期：1984-05-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：2004-08-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(91)90467-h
更新日期：1991-07-01 00:00:00
abstract：:The mammalian kidney consists of an array of tubules connected to a ductal system that collectively function to control water/salt balance and to remove waste from the organisms' circulatory system. During mammalian embryogenesis, three kidney structures form within the intermediate mesoderm. The two most anterior str...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2008.03.044
更新日期：2008-07-15 00:00:00
abstract：:The distribution of the catalytic and regulatory subunits of the cAMP-dependent protein kinase between cytoplasm and nucleus was determined during the development of Dictyostelium discoideum. In vegetative amoebae approximately 2% of the subunits were in the nucleus. During development there was an approximately 5-fol...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(86)90221-6
更新日期：1986-05-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/s0012-1606(03)00250-1
更新日期：2003-09-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2013.02.015
更新日期：2013-05-01 00:00:00
abstract：:Two 80- to 100-kb chromosomal replicons containing clustered chorion genes amplify in the ovarian follicle cells during the final 22 hr of Drosophila oogenesis. We have studied the relationship between amplification and transcription within one of these domains, located at 7E10-7F3,4 on the X chromosome. A tandem clus...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(86)90372-6
更新日期：1986-09-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：2015-06-15 00:00:00
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pub_type： 杂志文章
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更新日期：2015-04-15 00:00:00
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pub_type： 杂志文章
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更新日期：2009-06-15 00:00:00
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pub_type： 杂志文章
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journal_title：Developmental biology
pub_type： 杂志文章
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：2006-12-15 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：1987-07-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：1992-10-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2005.07.025
更新日期：2005-10-01 00:00:00
abstract：:Kidney development is a complex, little understood process based on inductive interactions and intricate epithelial and mesenchymal morphogenesis. Here, we report the use of subtractive hybridization to clone cDNAs expressed in early nephrogenesis. cDNA made from E14.5 mouse kidney was hybridized with adult mouse live...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1995.1139
更新日期：1995-05-01 00:00:00
