Biomechanical parameters of the cornea after collagen crosslinking measured by waveform analysis.

Abstract:

PURPOSE:To compare 2 corneal biomechanical parameters--corneal hysteresis (CH) and corneal resistance factor (CRF)--before and after collagen crosslinking (CXL) for keratoconus. SETTING:Eye Research Center of Mashhad University of Medical Sciences, Khatam-al-Anbia Eye Hospital, Mashhad, and Department of Ophthalmology, Baqiyatallah University of Medical Science, Tehran, Iran. DESIGN:Case series study. METHODS:Topical riboflavin was applied to the deepithelialized cornea every 3 minutes for 30 minutes and every 5 minutes during ultraviolet-A irradiation of the cornea. Corneal hysteresis and CRF were measured by biomechanical waveform analysis (Ocular Response Analyzer) before and 6 months after CXL. The values were compared using the paired Student t test. RESULTS:The study comprised 51 patients (56 eyes). The mean age of the patients was 23.27 years ± 6.3 (SD). Before CXL, the mean CH was 7.9 ± 1.5 mm Hg and the mean CRF was 7.3 ± 1.4 mm Hg. Six months after CXL, the mean values were 8.20 ± 1.5 mm Hg and 7.59 ± 1.5 mm Hg, respectively. The changes in CH and CRF were not statistically significant (P>.05). The changes in central corneal thickness and Goldmann-correlated intraocular pressure (IOP) between preoperatively and postoperatively were not statistically significant, although the change in corneal-compensated IOP was (P<.05). CONCLUSION:Although previous in vitro studies found a change in corneal rigidity, this study found no significant change in CH or CHF measured by biomechanical waveform analysis.

authors

Sedaghat M,Naderi M,Zarei-Ghanavati M

doi

10.1016/j.jcrs.2010.06.056

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

1728-31

issue

10

eissn

0886-3350

issn

1873-4502

pii

S0886-3350(10)01207-1

journal_volume

36

pub_type

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