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Rapidly progressing bilateral cataracts in a patient with beta thalassemia and pellagra.

Abstract：

:Soon after the diagnosis of pellagra in a 20-year-old patient with beta thalassemia, bilateral intumescent cataracts rapidly developed. We believe the patient's crystalline lenses were at an increased oxidative state due to iron overload from the thalassemia. Depletion of the lens epithelial cells of an important antioxidative agent (glutathione) as a result of niacin (vitamin B3) deficiency due to pellagra reduced the antioxidative capacity of the lenses. The oxidative damage led to rapid development of cataracts.

journal_name

J Cataract Refract Surg

journal_title

Journal of cataract and refractive surgery

authors

Athanasiadis I,Konstantinidis A,Kyprianou I,Robinson R,Moschou V,Kouzi-Koliakos K

doi

10.1016/j.jcrs.2007.05.011

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

1659-61

issue

9

eissn

0886-3350

issn

1873-4502

pii

S0886-3350(07)00894-2

journal_volume

33

pub_type

杂志文章

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