Abstract：
PURPOSE:To study the possible mechanisms of cataractogenesis by evaluating the characteristics of cataractous lens epithelial cells (LECs) in different types of human cataract. SETTING:Kangnam St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea. METHODS:Lens epithelial cells attached to the anterior capsules in eyes with nuclear or anterior subcapsular were analyzed for morphological characteristics by electron microscopy and for cellular characteristics by immunohistochemistry. RESULTS:Human LECs beneath the anterior capsule were degenerated in nuclear cataracts and were transdifferentiated in anterior polar cataracts. In senile nuclear cataractous lenses, LECs beneath the anterior capsule showed degenerative changes in morphology. In nuclear cataracts, LECs were immunohistochemically positive for cytokeratin and vimentin, while those in anterior polar cataracts were positive for vimentin only. The LECs of anterior subcapsular cataracts were transdifferentiated into spindle-shaped fibroblast-like cells without cellular junctions and embedded within a fibrillar meshwork mass. The extracellular matrixes in the anterior capsule of anterior subcapsular cataracts were immunohistochemically positive for fibronectin, laminin, collagen type I, and collagen type IV. CONCLUSIONS:Lens epithelial cells in different types of cataracts have distinct cellular characteristics and may possess a bipotential nature with the ability to transdifferentiate into mesenchymal cells. This may be an underlying mechanism for the development of cataract and capsule opacification.
journal_name
J Cataract Refract Surgjournal_title
Journal of cataract and refractive surgeryauthors
Joo CK,Lee EH,Kim JC,Kim YH,Lee JH,Kim JT,Chung KH,Kim Jdoi
10.1016/s0886-3350(99)00009-7subject
Has Abstractpub_date
1999-05-01 00:00:00pages
652-8issue
5eissn
0886-3350issn
1873-4502pii
S0886335099000097journal_volume
25pub_type
杂志文章abstract：PURPOSE:Iris intraocular implants were developed to manage congenital or traumatic iris defects. However, they are also used to change the color of patient eyes. The aim of this retrospective series was to report complications in patients managed in France after cosmetic implantation. SETTING:Ophthalmological institut...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1097/j.jcrs.0000000000000032
更新日期：2020-01-01 00:00:00
abstract：PURPOSE:To perform a pilot study of a new in-the-bag Fresnel prism intraocular lens (IOL) designed to deviate the image from diseased to healthy retina in eyes with bilateral age-related macular degeneration (AMD). SETTING:Anterior segment subspeciality practice, Pretoria, South Africa. DESIGN:Prospective nonmasked t...
journal_title：Journal of cataract and refractive surgery
pub_type： 临床试验,杂志文章
doi：10.1016/j.jcrs.2013.10.049
更新日期：2014-07-01 00:00:00
abstract：PURPOSE:To examine the outcomes of photoastigmatic refractive keratectomy using corneal and refractive parameters for myopia and astigmatism in eyes with forme fruste and mild keratoconus. SETTING:Private practice, Melbourne, Australia. METHODS:Photoastigmatic refractive keratectomy was performed with a Star 1 or Sta...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2006.12.014
更新日期：2007-04-01 00:00:00
abstract：PURPOSE:To determine the relation between ablation zone decentration, measured by corneal topography, and visual and refractive outcome, contrast sensitivity, glare, and subjective reports of halos after photorefractive keratectomy (PRK). SETTING:Eye Foundation, University of Missouri-Kansas City School of Medicine. ...
journal_title：Journal of cataract and refractive surgery
pub_type： 临床试验,杂志文章
doi：10.1016/s0886-3350(96)80305-1
更新日期：1996-07-01 00:00:00
abstract：:We report a case in which the capsular bag with an intraocular lens (IOL) and a capsular tension ring (CTR) dislocated into the vitreous. The dislocated foldable posterior chamber IOL and CTR were removed with a pars plana vitrectomy and exchanged with a scleral-fixated IOL. No complications occurred intraoperatively ...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2006.05.016
更新日期：2006-10-01 00:00:00
abstract：PURPOSE:To develop and test the validity of a surgical competency assessment tool for simulated small-incision cataract surgery (SICS). SETTING:Participating ophthalmologists contributed from 8 countries. DESIGN:Qualitative and quantitative development and evaluation of face and content validity of an assessment rubr...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jcrs.2019.04.010
更新日期：2019-09-01 00:00:00
abstract：PURPOSE:To determine the prevalence of laser corneal refractive surgery (laser vision correction [LVC]) among ophthalmologists who perform these procedures and to assess the willingness of these ophthalmologists to recommend LVC to immediate family members. SETTING:Online survey with results analyzed at Surgivision Co...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jcrs.2015.10.027
更新日期：2015-09-01 00:00:00
abstract：:Oscillopsia associated with near fixation after multifocal intraocular lens (IOL) implantation has not been fully recognized. A 46-year-old woman presented with shaking of vision in both eyes during near fixation after uneventful implantation of a single-piece multifocal posterior chamber IOL in both eyes. There was n...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1097/j.jcrs.0000000000000360
更新日期：2020-12-01 00:00:00
abstract：:This report details the case of a 65-year-old man with advanced cataract in which there was a large discrepancy between the K-readings taken with a keratometer and those taken with a TMS-1 videokeratoscope. It was suspected the discrepancy was caused by the advanced cataract in the presence of a dilated pupil. Repeat ...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(96)80155-6
更新日期：1996-12-01 00:00:00
abstract：:We present the case of a 56-year-old woman with moderate myopia and bilateral cataract who had cataract extraction and intraocular lens (IOL) implantation. Due to the patient's desire for spectacle independence, a trifocal IOL with toric correction for astigmatism was implanted. During the follow-up, it became obvious...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2016.02.001
更新日期：2016-03-01 00:00:00
abstract：:We introduce a technique for iris fixation of a posterior chamber intraocular lens (IOL) in which most of the procedure is done outside the eye. This minimizes intraocular manipulation, maximizes corneal endothelial preservation, and avoids the risk for IOL drop into the vitreous cavity intraoperatively. The IOL is fi...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2016.10.008
更新日期：2016-12-01 00:00:00
abstract：UNLABELLED:We describe a technique to rescue the continuous curvilinear capsulorhexis (CCC) in cases in which complete radial tears make it impossible to use normal traction forceps. A circumferential path and rapid movement are applied in the plane of the anterior capsule in the direction of the center pupil. This tec...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2012.02.019
更新日期：2012-05-01 00:00:00
abstract：PURPOSE:To assess the safety and effectiveness of an immunotoxin, MDX-RA, designed to inhibit posterior capsule opacification (PCO). SETTING:Eleven private practices in the United States. METHODS:This study comprised 63 eyes of 63 patients having extracapsular cataract extraction by phacoemulsification; these patient...
journal_title：Journal of cataract and refractive surgery
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0886-3350(98)80352-0
更新日期：1998-12-01 00:00:00
abstract：PURPOSE:To evaluate the relationship between the thinnest point in corneal thickness and the refractive state, keratometry, age, sex, and the ocular side. SETTING:Eye clinics in Germany and Austria and the Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. DESIGN:Cross-section...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2011.06.033
更新日期：2011-12-01 00:00:00
abstract：PURPOSE:To evaluate the repeatability of the Galilei dual-Scheimpflug analyzer in measuring corneal curvature, wavefront aberrations, pachymetry, and anterior chamber depth (ACD). SETTING:Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA. METHODS:Three consecutive measurements were performed in 1 ...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2009.09.034
更新日期：2010-03-01 00:00:00
abstract：PURPOSE:To evaluate the visual, refractive, contrast sensitivity, and aberrometric outcomes as well as the patient quality of life and photic phenomena disturbances after cataract surgery with implantation of a new trifocal toric intraocular lens (IOL). SETTINGS:Premium Clinic, Regional Hospital in Havlickuv Brod, Cze...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2015.07.033
更新日期：2015-12-01 00:00:00
abstract：PURPOSE:To study the effects on visual function of glistenings and folding marks in AcrySof (Alcon) intraocular lenses (IOLs). SETTING:Department of Ophthalmology, Dokuz Eylül University, School of Medicine, Izmir, Turkey. METHODS:This study included 91 eyes that had phacoemulsification and in-the-bag AcrySof IOL imp...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(01)00995-6
更新日期：2001-10-01 00:00:00
abstract：PURPOSE:To evaluate the visual and refractive outcomes, predictability, and stability of phakic intraocular lens (pIOL) implantation in keratoconic eyes and compare the results of 2 pIOL models. SETTING:Vissum Instituto Oftalmologico, Alicante, Spain. DESIGN:Retrospective case series. METHODS:An iris-claw (Artiflex)...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2013.07.052
更新日期：2014-03-01 00:00:00
abstract：PURPOSE:To monitor the change in the area of laser posterior capsulotomy over time to determine whether and when the area becomes stable. SETTING:Taipei Municipal Yang-Ming Hospital, Taipei, Taiwan, Republic of China. METHODS:This prospective study comprised 53 eyes (46 patients) with posterior capsule opacification ...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(00)00645-3
更新日期：2001-04-01 00:00:00
abstract：PURPOSE:To compare the outgrowth of lens epithelial cells (LECs) on 3 types of intraocular lenses (IOLs) to determine the influence of lens material and lens design (optic edge) on this phenomenon. SETTING:Department of Ophthalmology, University of Vienna, Medical School, Vienna, Austria. METHOD:Ninety eyes scheduled...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(00)00861-0
更新日期：2001-06-01 00:00:00
abstract：PURPOSE:To assess the safety, efficacy, stability, and predictability of collagen copolymer toric phakic intraocular lens (pIOL) implantation to correct myopia and astigmatism in eyes with keratoconus. SETTING:Fernández-Vega Ophthalmological Institute, Oviedo, Spain. METHODS:This prospective study comprised keratocon...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2009.11.032
更新日期：2010-06-01 00:00:00
abstract：PURPOSE:To describe 7 patients who developed ectasia following laser in situ kerato-mileusis (LASIK). SETTING:Instituto de la Visión, Buenos Aires, Argentina. METHODS:In this retrospective study of 7 patients, visual acuity, refraction, pachymetry, and corneal topography were examined before and after the refractive ...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(01)00799-4
更新日期：2001-09-01 00:00:00
abstract：PURPOSE:To compare 2 ultrasound (US) frequencies for phacoemulsification for moderate to hard cataract to determine a frequency that makes phacoemulsification safer and more efficacious. SETTING:Post Graduate Institute of Medical Education and Research, New Delhi, India. DESIGN:Randomized controlled trial. METHODS:P...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jcrs.2019.04.015
更新日期：2019-09-01 00:00:00
abstract：:We describe a technique for stromal expansion of thin and ultrathin corneas in keratoconus patients that uses refractive stromal lenticules of patients having small-incision lenticule extraction for myopic correction. The stromal lenticule is placed and spread over the host cornea following epithelial debridement so t...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2015.04.007
更新日期：2015-05-01 00:00:00
abstract：PURPOSE:To assess the predictability, efficacy, stability and safety of implantation of an Artisan (Ophtec BV, the Netherlands) iris-fixated phakic intraocular lens (IF-pIOL) for the correction of hyperopia with a follow-up of up to 15 years. SETTING:Leiden University Medical Center, The Netherlands METHODS:: Patients...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1097/j.jcrs.0000000000000532
更新日期：2020-11-27 00:00:00
abstract：PURPOSE:To demonstrate the use of polar value analysis of surgically induced astigmatism (SIA). SETTING:Department of Ophthalmology, Arhus University Hospital, Arhus, Denmark. METHODS:Univariate polar value analysis of SIA was demonstrated for a single patient and for aggregate data. Bivariate polar value analysis wa...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(00)00799-9
更新日期：2001-01-01 00:00:00
abstract：:A poly(methyl methacrylate)(PMMA) intraocular lens (IOL) dislocated into the vitreous cavity in 2 patients after a neodymium:YAG (Nd:YAG) laser posterior capsulotomy. In Case 1, the capsulotomy was performed 19 months after extracapsular cataract extraction (ECCE) and sulcus fixation of an IOL. Six months later the IO...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(98)80182-x
更新日期：1998-11-01 00:00:00
abstract：PURPOSE:To analyze the results of 1-way phacoemulsification and posterior chamber intraocular lens (IOL) implantation combined with trabeculectomy. SETTING:Department of Ophthalmology and Neurosurgery, University of Siena, Siena, Italy. METHODS:This retrospective study comprised 42 eyes of 36 patients with glaucoma a...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/s0886-3350(99)00269-2
更新日期：1999-12-01 00:00:00
abstract：PURPOSE:Comparison of lens capsule-related complications resulting from femtosecond laser-assisted capsulotomy and manual capsulorhexis in patients with white cataracts. SETTING:Eye Center, Second Affiliated Hospital, Zhejiang Medical School, Hangzhou, China. DESIGN:Prospective consecutive nonrandomized comparative c...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2018.10.037
更新日期：2019-03-01 00:00:00
abstract：PURPOSE:To evaluate the performance of the microincision Acri. Smart 46S intraocular lens (IOL) (Acri.Tec) in pediatric cataract surgery. SETTING:Department of Ophthalmology, Ludwig-Maximilians University, Munich, Germany. METHODS:Thirty-two consecutive eyes of 22 children who had cataract surgery with planned IOL im...
journal_title：Journal of cataract and refractive surgery
pub_type： 杂志文章
doi：10.1016/j.jcrs.2007.11.032
更新日期：2008-04-01 00:00:00
