Abstract:
OBJECTIVE:The development of a rapid immunofiltration (flow-through) test for the simultaneous detection of non-treponemal and treponemal antibodies in the serum of patients with syphilis. METHODS:The assay is rapid, inexpensive, and requires limited expertise in interpreting the results. The test is based on the principle of immunofiltration, with two antigens and control material spotted on the membrane of a through-flow device. A positive test is characterised by the appearance of three red/magenta spots within 2-10 min. RESULTS:A total of 376 banked serum samples obtained from the Georgia Public Health Laboratory was examined by the flow-through test, the rapid plasma reagin (RPR) test and the Treponema pallidum passive particle agglutination assay (TPPA). The sensitivity and specificity of the non-treponemal spot were 96.5% and 97.7%, respectively, when compared with the RPR test, and the sensitivity and specificity of the treponemal test spot were 97.3% and 99.1% when compared with the TPPA test. In addition, the test yielded equivalent results to those obtained in comparator tests when 104 sera from cases of syphilis of known stage, 49 sera from diseases other than syphilis and 23 sera known to exhibit biological false-positive reactions were tested in parallel. CONCLUSIONS:These results indicate that the dual treponemal and non-treponemal assay could be used as a screen and confirmatory test for the serological diagnosis of syphilis in remote or resource-poor settings where there is a need to provide counselling and treatment at the initial consultation.
journal_name
Sex Transm Infectjournal_title
Sexually transmitted infectionsauthors
Castro AR,Mody HC,Parab SY,Patel MT,Kikkert SE,Park MM,Ballard RCdoi
10.1136/sti.2010.042937subject
Has Abstractpub_date
2010-12-01 00:00:00pages
532-6issue
7eissn
1368-4973issn
1472-3263pii
sti.2010.042937journal_volume
86pub_type
杂志文章abstract:OBJECTIVES:To determine the prevalence of urethritis pathogens amongst male symptomatic urethritis (MUS) patients, genital ulcer (GUS) patients without urethritis symptoms and men requesting HIV testing at a voluntary counselling and testing (VCT) clinic. METHODS:A prospective study was conducted in Johannesburg, Sout...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2007.028464
更新日期:2008-08-01 00:00:00
abstract::Despite having the highest prevalence of any sexually transmitted infection (STI) globally, there is a dearth of data describing Trichomonas vaginalis (TV) incidence and prevalence in the general population. The lack of basic epidemiological data is an obstacle to addressing the epidemic. Once considered a nuisance in...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,评审
doi:10.1136/sextrans-2013-051075
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:To compare and contrast attitudes and behaviours of family doctors and patients with regard to genital herpes and its management. METHODS:Family doctors and infected patients were surveyed online to explore disease importance/seriousness, emotional impact, transmission and treatment. The study received ethic...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
doi:10.1136/sti.2007.027631
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVE:To describe patterns of HIV infection among stable sexual partnerships across sub-Saharan Africa (SSA). METHODS:The authors defined measures of HIV discordancy and conducted a comprehensive quantitative assessment of discordancy among stable partnerships in 20 countries in SSA through an analysis of the Demo...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
doi:10.1136/sextrans-2011-050114
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVES:While much research to date has examined female sex trade work, little has been done to evaluate factors associated with male sex trade involvement or to assess their health service needs. This is particularly true for male sex trade workers who are also injection drug users (IDUs). Therefore, the present an...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2004.011106
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVES:To investigate the impact of a health adviser in genitourinary medicine as a training and support resource on the management of Chlamydia trachomatis in a large inner city health centre. METHODS:A large, inner city health centre was selected at random for the intervention, with another selected as control. ...
journal_title:Sexually transmitted infections
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/sti.79.5.369
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:Identifying predictors that contribute to geographical disparities in sexually transmitted infections (STIs) is necessary. This study assesses the spatial relationship between condom availability to locations of STIs in order to better understand these geographical disparities. OBJECTIVES:We conducted a con...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2015-052144
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:To pilot and evaluate sexually transmitted infection (STI) management in community family planning clinics (FPCs). METHODS:Number of STI tests taken, positive results, infections treated, contacts traced/treated, referrals to specialist services and time from testing to treatment were documented as well as a...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2003.004382
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND:Genital herpes (GH) is a common sexually transmitted infection. Novel tools for the control of GH (for example, tests and vaccines) are emerging, but optimal assessment of the cost effectiveness of such interventions requires scaled, preference based estimates of the impact of GH on health related quality of...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
doi:10.1136/sti.2004.011619
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVES:To investigate the epidemiology of sexually transmitted infections (STI) among female sex workers (FSW) in Kaiyuan city, Yunnan province, China, and to identify risk factors associated with STI. METHODS:A cross-sectional study of 737 FSW was carried out from March to May 2006, with confidential interviews a...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2008.033100
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:In settings with poor sexually transmitted infection (STI) control in high-risk groups, periodic presumptive treatment (PPT) can quickly reduce the prevalence of genital ulcers, Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT). However, few studies have assessed the impact on HIV. Mathematical model...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
doi:10.1136/sti.2008.034678
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVES:The diagnosis and treatment of Chlamydia trachomatis infection is important in preventing persistent or recurrent infection. Expedited partner therapy (EPT) is the favoured and supported method for STI treatment of the Centers for Disease Control and Prevention when the provider cannot be assured that all re...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2016-052887
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:To investigate the possible involvement of human trichomonads (Pentatrichomonas hominis and Trichomonas tenax) other than Trichomonas vaginalis in the aetiology of vaginal trichomoniasis. METHODS:Vaginal swabs taken from women attending antenatal clinics were tested for Trichomonas vaginalis by traditional a...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2006.020941
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVES:To assess HIV and syphilis prevalence, HIV-related behaviours and testing for HIV in female sex workers (FSW) in Sudan. DESIGN:Bio-behavioural surveys using respondent-driven sampling were carried out among FSW in the capital cities of 14 states in Sudan in 2011-2012. HIV and syphilis testing was done by ra...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
doi:10.1136/sextrans-2013-051097
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVES:To assess the effectiveness of an internet-accessed STI (e-STI) testing and results service on testing uptake among young adults (16-30 years) who have never tested for STIs in London, England. METHODS:We conducted secondary analyses on data from a randomised controlled trial. In the trial, participants wer...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,随机对照试验
doi:10.1136/sextrans-2019-053992
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:The Spectrum program is used to estimate key HIV indicators from the trends in incidence and prevalence estimated by the Estimation and Projection Package or the Workbook. These indicators include the number of people living with HIV, new infections, AIDS deaths, AIDS orphans, the number of adults and childr...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2010.044222
更新日期:2010-12-01 00:00:00
abstract:OBJECTIVE:To assess HIV prevalence and predictive factors for HIV among male sex workers in Spain. METHODS:In this study we analysed all male sex workers who visited HIV testing clinics in 19 Spanish cities between 2000 and 2002. The information was obtained during examination by means of a brief questionnaire. For re...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
doi:10.1136/sti.2003.008649
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVES:During the last decades, a changing epidemiological pattern of genital herpes simplex virus (HSV) infection has emerged. Primary infection is now caused as often by HSV-1 as by HSV-2. Once established, HSV can be reactivated leading to recurrent mucocutaneous lesions as well as meningitis. Why some otherwise...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2016-052811
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVES:To validate a simplified grading scheme for Gram stained smears of vaginal fluid for the diagnosis of bacterial vaginosis (BV) against the accepted "gold" standard of Amsel's composite criteria. METHODS:Women attending genitourinary medicine (GUM) clinics, as part of a multicentre study, were diagnosed as h...
journal_title:Sexually transmitted infections
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1136/sti.78.6.413
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVE:Prior studies have shown that men who have sex with men (MSM) who attend sex clubs or parties are at higher risk for HIV and other STIs than those who do not. We sought to provide data about MSM who attend sex clubs/parties in New York City (NYC) in the era of biomedical HIV prevention. METHODS : We conducted...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2018-053816
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVE:To determine feasibility, validity, and cost effectiveness of the syndromic approach to male patients with urethral discharge in Bandung, Indonesia. METHODS:The WHO algorithm on urethral discharge with no microscopy available was evaluated. Patients presented with a complaint of urethral discharge and if dis...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:
更新日期:1998-06-01 00:00:00
abstract:OBJECTIVES:To assess changes in seroadaptive behaviours among men who have sex with men (MSM) in San Francisco over the past 4 years. METHODS:461 MSM were recruited in 2008 as the second wave of the US National HIV Behavioural Surveillance (NHBS) survey in San Francisco. Participants were classified into patterns of s...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2010.042986
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVES:To determine the prevalence and risk factors for human papillomavirus (HPV) infection in female sex workers (FSW) in Lima, Peru. METHODS:Cross-sectional study of 87 FSW. Information regarding demographics, sex work practices, and genital and blood specimens was collected. RESULTS:Forty-four (50.6%) of 87 F...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2010.043315
更新日期:2011-02-01 00:00:00
abstract::Recent advances in genetic characterisation of Trichomonas vaginalis isolates show that the extensive clinical variability in trichomoniasis and its disease sequelae are matched by significant genetic diversity in the organism itself, suggesting a connection between the genetic identity of isolates and their clinical ...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,评审
doi:10.1136/sextrans-2013-051098
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:Mother-to-child transmission (MTCT) of syphilis and HIV continue to be important yet preventable causes of perinatal and infant morbidity and mortality. OBJECTIVES:To systematically review, critically appraise and perform a meta-analysis to evaluate the operational characteristics of dual rapid diagnostic t...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,meta分析,评审
doi:10.1136/sextrans-2016-053069
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVES:To present the current epidemiology of prevalent diagnosed HIV infections in England, Wales, and Northern Ireland (E, W, & NI) and describe trends over time. METHODS:Descriptive analyses of the annual national Survey of Prevalent HIV Infections Diagnosed (SOPHID) for the period 1997 to 2003. RESULTS:In 200...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2004.012070
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVES:A key indicator of success of HIV prevention programmes is the number of female sex worker (FSW) sex acts protected by condoms. This measure usually relies on FSW reports, which may be biased. We examined condom availability data in five Karnataka districts to estimate the proportion of FSW sex acts potentia...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2009.038398
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:Genital warts (condyloma acuminatum) remain one of the most commonly reported sexually transmitted infections (STI) worldwide. Most genital warts are caused by non-oncogenic human papilloma virus. Recurrence is common and many patients receive several rounds of treatment. There are limited data in the litera...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2008.030999
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVES:Although the prevalence of sexually transmitted infections (STIs) among girls infected with HIV has been reported, the incidence of STI diagnoses has not been well documented. The objectives of this study were to examine (1) incident STI diagnoses and (2) the association between viral load (VL) and incident ...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2007.026161
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of sexual dysfunction and dissatisfaction (SD) among new heterosexual attendees at a central London genitourinary medicine (GUM) clinic. METHODS:Consecutive new attendees seen by a single clinician were asked a probe question about SD in the previous year. A clinical interview fol...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.76.3.208
更新日期:2000-06-01 00:00:00