Abstract:
BACKGROUND:In settings with poor sexually transmitted infection (STI) control in high-risk groups, periodic presumptive treatment (PPT) can quickly reduce the prevalence of genital ulcers, Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT). However, few studies have assessed the impact on HIV. Mathematical modelling is used to quantify the likely HIV impact of different PPT interventions. METHODS:A mathematical model was developed to project the impact of PPT on STI/HIV transmission amongst a homogeneous population of female sex workers (FSWs) and their clients. Using data from Johannesburg, the impact of PPT interventions with different coverages and PPT frequencies was estimated. A sensitivity analysis explored how the projections were affected by different model parameters or if the intervention was undertaken elsewhere. RESULTS:Substantial decreases in NG/CT prevalence are achieved among FSWs receiving PPT. Although less impact is achieved among all FSWs, large decreases in NG/CT prevalence (>50%) are possible with >30% coverage and supplying PPT every month. Higher PPT frequencies achieve little additional impact, whereas improving coverage increases impact until NG/CT becomes negligible. The impact on HIV incidence is smaller, longer to achieve, and depends heavily on the assumed NG/CT cofactors, whether they are additive, the assumed STI/HIV transmission probabilities and STI durations. Greater HIV impact can be achieved in settings with lower sexual activity (except at high coverage), less STI treatment or high prevalences of Haemophilus ducreyi. CONCLUSIONS:Despite the model's assumption of homogeneous risk behaviour probably resulting in optimistic projections, and uncertainty in STI cofactors and transmission probabilities, projections suggest PPT interventions with sufficient coverage (> or = 40%) and follow-up (> or = 2 years) could noticeably decrease the HIV incidence (>20%) among FSW populations with inadequate STI treatment.
journal_name
Sex Transm Infectjournal_title
Sexually transmitted infectionsauthors
Vickerman P,Ndowa F,O'Farrell N,Steen R,Alary M,Delany-Moretlwe Sdoi
10.1136/sti.2008.034678subject
Has Abstractpub_date
2010-06-01 00:00:00pages
163-8issue
3eissn
1368-4973issn
1472-3263pii
sti.2008.034678journal_volume
86pub_type
杂志文章,多中心研究abstract:OBJECTIVES:To develop, evaluate and implement a new multiplex real-time PCR test for the detection of herpes simplex virus (HSV)1, HSV2 and syphilis in a single sample using a single test. METHODS:A multiplex real-time PCR test detecting HSV1, HSV2 and Treponema pallidum was designed, validated and evaluated for a per...
journal_title:Sexually transmitted infections
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journal_title:Sexually transmitted infections
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journal_title:Sexually transmitted infections
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journal_title:Sexually transmitted infections
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更新日期:2013-09-01 00:00:00
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journal_title:Sexually transmitted infections
pub_type: 杂志文章
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journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2016-052719
更新日期:2017-06-01 00:00:00
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journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
doi:10.1136/sti.2008.034314
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVES:Geosocial networking application specific to men who have sex with men (MSM) (gay app) has revolutionised the social networking of MSM globally, much concern was raised over its linkage to HIV/syphilis risk. This study sought to examine the association between use of gay app and sexual behaviours and HIV/syp...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2018-053902
更新日期:2019-11-01 00:00:00
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journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2013-051279
更新日期:2014-05-01 00:00:00
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journal_title:Sexually transmitted infections
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journal_title:Sexually transmitted infections
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2012-02-01 00:00:00
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journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.76.2.98
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND:HIV is now well established in the Caribbean, with prevalence in several countries being surpassed only by those of sub-Saharan Africa. Continuing inward migration from the Caribbean and a high incidence of some bacterial STIs among Britain's black Caribbean communities, suggests a considerable potential for...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2003.006163
更新日期:2004-02-01 00:00:00
abstract::The distribution of HIV-1 subtypes in a population tracks the spread and evolution of the epidemic. This study is a systematic review of all available evidence on HIV-1 molecular epidemiology and subtype distribution in the Middle East and North Africa. Sources of data included Medline and various institutional docume...
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pub_type: 杂志文章,评审
doi:10.1136/sti.2010.043711
更新日期:2011-03-01 00:00:00
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journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2012-050564
更新日期:2013-05-01 00:00:00
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journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2016-02-01 00:00:00
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更新日期:2003-12-01 00:00:00
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journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
doi:10.1136/sti.2009.041293
更新日期:2010-10-01 00:00:00
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journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2003.006106
更新日期:2004-02-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2015-03-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2009-02-01 00:00:00
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journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
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更新日期:2008-11-01 00:00:00
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journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2005.019513
更新日期:2006-12-01 00:00:00
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journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
doi:10.1136/sti.2005.016097
更新日期:2005-12-01 00:00:00
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journal_title:Sexually transmitted infections
pub_type: 杂志文章,评审
doi:10.1136/sti.2005.016022
更新日期:2006-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1136/sti.74.5.345
更新日期:1998-10-01 00:00:00
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journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.77.2.114
更新日期:2001-04-01 00:00:00
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journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
doi:10.1136/sextrans-2013-051294
更新日期:2014-05-01 00:00:00
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journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2015-052246
更新日期:2016-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1136/sti.2010.046284
更新日期:2011-06-01 00:00:00