Herpes simplex virus specific T cell response in a cohort with primary genital infection correlates inversely with frequency of subsequent recurrences.

Abstract:

OBJECTIVES:During the last decades, a changing epidemiological pattern of genital herpes simplex virus (HSV) infection has emerged. Primary infection is now caused as often by HSV-1 as by HSV-2. Once established, HSV can be reactivated leading to recurrent mucocutaneous lesions as well as meningitis. Why some otherwise immune-competent individuals experience severe and frequent recurrences is not known, and the immunological mechanism underlying recurrent symptomatic HSV infection is not fully understood. In this study, we investigate and characterise the immune response of patients with first episode of HSV genital infection and its relation to the frequency of symptomatic recurrences. METHODS:In this cohort study, clinical and immunological data were collected from 29 patients who were followed 1 year after presenting with a first episode of genital or meningeal HSV infection. They were classified by PCR and serology as those with primary HSV-1, primary HSV-2 and non-primary HSV-2 infection. RESULTS:HSV-specific interleukin(Il)-4 and Il-10 responses at first visit were higher in primary infected HSV-2 infected patients experiencing lower numbers of recurrences during subsequent year. CONCLUSIONS:The median number of recurrences following primary HSV-2 genital infection may partly be predicted by the strength of an early HSV-specific IL-4 and IL-10 response.

journal_name

Sex Transm Infect

authors

Franzen-Röhl E,Schepis D,Atterfelt F,Franck K,Wikström A,Liljeqvist JÅ,Bergström T,Aurelius E,Kärre K,Berg L,Gaines H

doi

10.1136/sextrans-2016-052811

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

169-174

issue

3

eissn

1368-4973

issn

1472-3263

pii

sextrans-2016-052811

journal_volume

93

pub_type

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