Abstract:
:In rat mesenteric arteries, smooth muscle cells exhibit intercellular calcium waves in response to local phenylephrine stimulation. These waves have a velocity of approximately 20 cells/s and a range of approximately 80 cells. We analyze these waves in a theoretical model of a population of coupled smooth muscle cells, based on the hypothesis that the wave results from cell membrane depolarization propagation. We study the underlying mechanisms and highlight the importance of voltage-operated channels, calcium-induced calcium release, and chloride channels. Our model is in agreement with experimental observations, and we demonstrate that calcium waves presenting a velocity of approximately 20 cells/s can be mediated by electrical coupling. The wave velocity is limited by the time needed for calcium influx through voltage-operated calcium channels and the subsequent calcium-induced calcium release, and not by the speed of the depolarization spreading. The waves are partially regenerated, but have a spatial limit in propagation. Moreover, the model predicts that a refractory period of calcium signaling may significantly affect the wave appearance.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Koenigsberger M,Seppey D,Bény JL,Meister JJdoi
10.1016/j.bpj.2010.04.031subject
Has Abstractpub_date
2010-07-21 00:00:00pages
333-43issue
2eissn
0006-3495issn
1542-0086pii
S0006-3495(10)00529-1journal_volume
99pub_type
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