The Cole-Moore Effect: Still Unexplained?

Abstract:

:In the first issue, on the first page of the Biophysical Journal in 1960, Cole and Moore provided the first confirmation of the Hodgkin and Huxley formulation of the sodium and potassium conductances that underlie the action potential. In addition, working with the squid giant axon, Cole and Moore noted that strong hyperpolarization preceding a depolarizing voltage-clamp pulse delayed the rise of the potassium conductance: once started, the time course of the rise was always the same but after significant hyperpolarization there was a long lag before the rise began. This phenomenon has come to be known as the Cole-Moore effect. Their article examines and disproves the hypothesis that the lag reflects the time required to refill the membrane with potassium ions after the ions are swept out of the membrane into the axoplasm by hyperpolarization. The work by Cole and Moore indirectly supports the idea of a membrane channel for potassium conductance. However, the mechanism of the Cole-Moore effect remains a mystery even now, buried in the structure of the potassium channel, which was completely unknown at the time.

journal_name

Biophys J

journal_title

Biophysical journal

authors

Hoshi T,Armstrong CM

doi

10.1016/j.bpj.2015.07.052

subject

Has Abstract

pub_date

2015-10-06 00:00:00

pages

1312-6

issue

7

eissn

0006-3495

issn

1542-0086

pii

S0006-3495(15)00819-X

journal_volume

109

pub_type

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