Valproate in children with newly diagnosed idiopathic generalized epilepsy.

Abstract:

OBJECTIVES:Sparse information on dose-response characteristics for initial antiepileptic drug monotherapy in children with idiopathic generalized epilepsy (IGE) is available. The aim of this study is to characterize the therapeutic dose of valproate in children with newly diagnosed IGE. MATERIALS AND METHODS:Effect of initial valproate monotherapy and doses associated with seizure freedom were examined in consecutive children with IGE identified from a New Onset Seizure Clinic. RESULTS:Of 84 patients identified, 48 (57%) became seizure-free on valproate monotherapy and another 10 patients became seizure-free but discontinued VPA because of adverse effects. The mean dose in seizure-free children was 15.7 mg/kg/day and over 95% of IGE patients will respond below 25 mg/kg/day. CONCLUSIONS:Half of children became seizure-free on valproate monotherapy and did so at modest doses.

journal_name

Acta Neurol Scand

authors

Holland KD,Monahan S,Morita D,Vartzelis G,Glauser TA

doi

10.1111/j.1600-0404.2009.01308.x

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

149-53

issue

3

eissn

0001-6314

issn

1600-0404

pii

ANE1308

journal_volume

121

pub_type

杂志文章
  • Evoked potentials and CSF-immunoglobulins in MS: relationship to disease duration, disability, and functional status.

    abstract::In 100 MS patients, BAEP and tibial SEP abnormality rates increased significantly with disease duration and clinical disability. VEP correlated non-linearly with disease duration, and median nerve SEP correlated with disability. In multifactorial analysis, however, BAEP correlated significantly only with clinical brai...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1990.tb04491.x

    authors: Sand T,Sulg IA

    更新日期:1990-09-01 00:00:00

  • M-wave analysis and passive tilt in patients with different degrees of carotid artery disease.

    abstract:BACKGROUND AND PURPOSE:Carotid artery disease (CAD) is able to critically impair cerebral autoregulation which increases the risk for stroke. As therapeutic strategy largely depends on the degree of CAD, we investigated whether this gradation is also related to significant changes in autoregulatory capacity. We applied...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0404.2003.00210.x

    authors: Haubrich C,Klemm A,Diehl RR,Möller-Hartmann W,Klötzsch C

    更新日期:2004-03-01 00:00:00

  • "Chronic painter's syndrome". A reanalysis of psychological test data in a group of diagnosed cases, based on comparisons with matched controls.

    abstract::Twenty solvent-exposed workers, most of them painters, had been diagnosed as cases of toxic encephalopathy in 1978/79. Two years later they were re-examined with an extensive battery of neuropsychological tests. Their performance was unchanged on retesting. We have now compared their test results with those of non-exp...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1988.tb05913.x

    authors: Gade A,Mortensen EL,Bruhn P

    更新日期:1988-04-01 00:00:00

  • Thymic lymphoepitheliomas and skeletal muscle expressing common antigen(s).

    abstract::Rabbit antiserum to a citric acid extract of human skeletal muscle (CA) stained epithelial thymoma cells as well as skeletal muscle. Thymomas from two myasthenia gravis (MG) patients showing no circulating anti-CA antibodies prior to thymectomy were also stained by the antiserum. Thus, in these patients as well, the t...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1986.tb03300.x

    authors: Gilhus NE,Matre R,Aarli JA,Hofstad H,Thunold S

    更新日期:1986-04-01 00:00:00

  • Incidence and significance of adverse effects of albendazole therapy in patients with a persistent solitary cysticercus granuloma.

    abstract:OBJECTIVE:To study the incidence of adverse reactions to albendazole therapy in patients presenting with seizures and a persistent (>3 months after diagnosis), solitary cysticercus granuloma and to determine whether the occurrence of adverse reactions predicted the response of the granuloma to therapy. MATERIAL AND ME...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1998.tb01730.x

    authors: Rajshekhar V

    更新日期:1998-08-01 00:00:00

  • Abnormalities of T-lymphocyte subsets in epileptic patients.

    abstract::This study concerns the distribution of T-cell subsets as determined by specific monoclonal antibodies in 50 individuals with complex partial seizures (31) and primary generalized tonic-clonic seizures (19), and in 30 healthy controls. The epileptic group had significantly fewer circulating T4 "helper" lymphocytes and...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1985.tb00855.x

    authors: Eeg-Olofsson O,Prchal JF,Andermann F

    更新日期:1985-08-01 00:00:00

  • Dynamic F wave study in patients suffering from peripheral arterial occlusive disease.

    abstract:OBJECTIVE:To prospectively detect significant transient F wave abnormalities obtained after exercise in patients with peripheral arterial disease (PAD) and to assess the potential diagnostic sensitivity of dynamic F wave study in such a context. PATIENTS AND METHODS:A series of 40 electrical stimuli were delivered to ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2006.00725.x

    authors: Argyriou AA,Tsolakis I,Papadoulas S,Polychronopoulos P,Gourzis P,Chroni E

    更新日期:2007-02-01 00:00:00

  • Evaluation of fatigue in Parkinson's disease patients with stimulated single fiber electromyography.

    abstract:OBJECTIVES:Fatigue is a disabling and dopa-resistant symptom in Parkinson's disease (PD). Pathological studies have shown that both peripheral and central cholinergic systems are involved in PD. Electrophysiological investigation showed decremental muscle responses following repetitive nerve stimulation (RNS). We hypot...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0404.2001.00046.x

    authors: Hwang WJ,Lin TS

    更新日期:2001-11-01 00:00:00

  • Cerebrospinal fluid markers in MS patients and their healthy siblings.

    abstract::In a previous study we found that nine of 47 siblings to multiple sclerosis (MS) patients with a normal neurological examination carry an intrathecal oligoclonal immunopathy with limited specificity, a condition we termed MS immunopathic trait. The purpose of this study is to further characterize the MS immunopathic t...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0404.2003.00197.x

    authors: Haghighi S,Andersen O,Odén A,Rosengren L

    更新日期:2004-02-01 00:00:00

  • Serum soluble interleukin-2 receptor levels in chronic progressive, stable and steroid-treated multiple sclerosis.

    abstract::Serum levels of the soluble interleukin-2 receptor (sIL-2R), an indicator of T cell activation, were significantly elevated in chronic progressive MS (CPMS) patients, clinically stable MS patients and in patients with other neurological diseases (OND) as compared to healthy controls. Levels of sIL-2R in steroid treate...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1991.tb04955.x

    authors: Bansil S,Troiano R,Cook SD,Rohowsky-Kochan C

    更新日期:1991-10-01 00:00:00

  • Neuropsychological assessment in MS: clinical, neurophysiological and neuroradiological relationships.

    abstract::We assessed cognitive performance and its relationship with clinical and anatomic disease severity in MS with mild to moderate handicap; 34 definite MS and 18 healthy subjects matched for age and education were submitted to a neuropsychological test battery. Both groups were examined for anxiety. MS patients underwent...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1992.tb05052.x

    authors: Maurelli M,Marchioni E,Cerretano R,Bosone D,Bergamaschi R,Citterio A,Martelli A,Sibilla L,Savoldi F

    更新日期:1992-08-01 00:00:00

  • Genetic factors in temporal lobe epilepsy.

    abstract::Genetic investigation of 74 patients with temporal lobe epilepsy, resistant to medication, who underwent unilateral temporal lobectomy 1960-1969. Thirty per cent had a positive family history of epilepsy; 49 per cent of other neurological diseases; and 46 per cent of major psychiatric disorders. Neither of the genetic...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1975.tb05833.x

    authors: Jensen I

    更新日期:1975-11-01 00:00:00

  • ECG changes in epilepsy patients.

    abstract:OBJECTIVES:To investigate the frequency of ECG abnormalities suggestive of myocardial ischaemia in patients with severe drug resistant epilepsy and without any indication of previous cardiac disease, assuming that these changes may be of significance for the group of epileptic patients with sudden unexpected death. MA...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1997.tb00242.x

    authors: Tigaran S,Rasmussen V,Dam M,Pedersen S,Høgenhaven H,Friberg B

    更新日期:1997-08-01 00:00:00

  • Phosphomannosyl receptors of lysosomal enzymes of skeletal muscle in neuromuscular diseases.

    abstract::The phosphomannosyl receptor system is responsible for both the receptor-mediated endocytosis and the intracellular transport of lysosomal enzymes. In the present study this receptor system was examined in affected muscles of patients with various neuromuscular diseases. The total activity of beta-N-acetyl-glucosamini...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1988.tb05941.x

    authors: Salminen A,Marjomäki V,Tolonen U,Myllylä VV

    更新日期:1988-06-01 00:00:00

  • Probabilistic ictal EEG sources and temporal lobe epilepsy surgical outcome.

    abstract:OBJECTIVE:For patients with medication refractory medial temporal lobe epilepsy (MTLE), surgery offers the hope of a cure. However, up to 30% of patients with MTLE continue to experience disabling seizures after surgery. The reasons why some patients do not achieve seizure freedom are poorly understood. A promising the...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12253

    authors: Breedlove J,Nesland T,Vandergrift WA 3rd,Betting LE,Bonilha L

    更新日期:2014-08-01 00:00:00

  • Prior poliomyelitis: an immunohistochemical study of cytoskeletal proteins and a marker for muscle fibre regeneration in relation to usage of remaining motor units.

    abstract::Patients with prior poliomyelitis with paresis and excessive use (n = 8) and low use (n = 6) of residual anterior tibial motor units (MUs) during walking were subjected to muscle biopsy of the anterior tibial muscle (TA). Antibodies directed against cytoskeletal proteins, spectrin and desmin, and against Leu-19, a myo...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1993.tb04091.x

    authors: Borg K,Edström L

    更新日期:1993-02-01 00:00:00

  • Systemic connective tissue abnormalities in patients with saccular intracranial aneurysms.

    abstract:OBJECTIVES:Our purpose was to identify the incidence and significance of markers of systemic connective tissue abnormalities (CTA) in patients with saccular intracranial aneurysms (SIA). MATERIALS AND METHODS:This prospective case-control study included 199 consecutive patients with SIA (103 women and 96 men, mean age...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12088

    authors: Lebedeva ER,Sakovich VP

    更新日期:2013-08-01 00:00:00

  • Acute and chronic pain syndromes in multiple sclerosis.

    abstract::A representative sample of 117 patients with definite multiple sclerosis (MS) was interviewed on pain syndromes. Chronic syndromes lasting more than one month included dysaestesthesia, low back pain, spasms, tonic seizures, tightening and painful sensations in the extremities. Acute syndromes included neuralgia, L'Her...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1991.tb04937.x

    authors: Stenager E,Knudsen L,Jensen K

    更新日期:1991-09-01 00:00:00

  • Bell's palsy: a manifestation of prediabetes?

    abstract:BACKGROUND:Idiopathic peripheral facial nerve palsy or Bell's palsy (BP) is the most common cause of facial nerve palsy. OBJECTIVE:To evaluate the role of glucose metabolism abnormalities in BP. METHODS:We identified 148 patients with unilateral BP and 128 control subjects. In all we evaluated glucose level at fastin...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2010.01365.x

    authors: Bosco D,Plastino M,Bosco F,Consoli A,Labate A,Pirritano D,Consoli D,Fava A

    更新日期:2011-01-01 00:00:00

  • Prediction of length of stay for stroke patients.

    abstract:OBJECTIVES:To examine the factors that influence acute and total length of stay (LOS) for stroke patients. MATERIALS AND METHODS:The basis of this investigation was a population-based cohort of first-ever stroke patients (n = 388). Subjects were survivors of the initial hospitalization (n = 295). Age, sex, social fact...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2006.00756.x

    authors: Appelros P

    更新日期:2007-07-01 00:00:00

  • The reliability of the MSFC and its components.

    abstract:BACKGROUND:The Multiple Sclerosis Functional Composite (MSFC) is a multidimensional measurement tool for multiple sclerosis (MS) including a measure of ambulation (Timed 25-foot Walk [TWT]), arm function (Nine-Hole Peg Test [9HPT]) and cognition (Paced Auditory Serial Addition Test [PASAT]). OBJECTIVES:To assess the r...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2007.00972.x

    authors: Rosti-Otajärvi E,Hämäläinen P,Koivisto K,Hokkanen L

    更新日期:2008-06-01 00:00:00

  • The Gulf War era multiple sclerosis cohort: 3. Early clinical features.

    abstract:OBJECTIVES:To present clinical features at diagnosis for a large nationwide incident cohort of multiple sclerosis (MS) among those serving in the US military during the Gulf War era (GWE). MATERIALS & METHODS:Medical records and databases from the Department of Veterans Affairs (VA) for cases of MS with onset in or af...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12810

    authors: Wallin MT,Culpepper WJ,Maloni H,Kurtzke JF

    更新日期:2018-01-01 00:00:00

  • Tau protein concentrations in cerebrospinal fluid of patients with multiple sclerosis.

    abstract:UNLABELLED:FUNDAMENTALS AND OBJECTIVE: Multiple sclerosis (MS) is the prototype of demyelinating disease, but recently, it has been shown that the existence of axonal lesions contribute to irreversible central nervous system damage in this disease. Tau proteins are considered to be important for maintaining the stabili...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1034/j.1600-0404.2002.01370.x

    authors: Jiménez-Jiménez FJ,Zurdo JM,Hernanz A,Medina-Acebrón S,de Bustos F,Barcenilla B,Sayed Y,Ayuso-Peralta L

    更新日期:2002-12-01 00:00:00

  • Anal sphincter electromyography in patients with newly diagnosed idiopathic parkinsonism.

    abstract:OBJECTIVES:The differential diagnosis of patients with idiopathic parkinsonism is difficult, especially early in the course of the disease. External anal sphincter electromyography (EAS-EMG) has been reported to be of value in the differential diagnosis between Parkinson's disease (PD) and multiple system atrophy (MSA)...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.2011.01633.x

    authors: Linder J,Libelius R,Nordh E,Holmberg B,Stenlund H,Forsgren L

    更新日期:2012-10-01 00:00:00

  • Frequent administration of levodopa/carbidopa microtablets vs levodopa/carbidopa/entacapone in healthy volunteers.

    abstract:OBJECTIVES:An oral dispersible microtablet formulation of levodopa/carbidopa 5/1.25 mg (LC-5) was developed for individualized repeated dosing. The aim was to compare pharmacokinetic profiles of LC-5 and levodopa/carbidopa/entacapone (LCE). MATERIALS AND METHODS:A randomized, crossover study was carried out in 11 heal...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1600-0404.2012.01700.x

    authors: Nyholm D,Ehrnebo M,Lewander T,Trolin CG,Bäckström T,Panagiotidis G,Spira J,Nyström C,Aquilonius SM

    更新日期:2013-02-01 00:00:00

  • WT1 and interferon-β-vitamin D association in MS: a longitudinal study.

    abstract:BACKGROUND:It has been suggested that polymorphisms in the WT1 gene modulate the effect of IFN-β treatment in multiple sclerosis (MS) through regulation of the relationship between IFN-β and vitamin D. OBJECTIVE:To examine whether WT1 modulates the relationship between IFN-β and vitamin D in a longitudinal study with ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/ane.12448

    authors: Holmøy T,Esbensen QY,Torkildsen Ø,Wergeland S,Bjerve KS,Beiske AG,Midgard R,Šaltytė-Benth J,Hovdal H,Myhr KM

    更新日期:2016-04-01 00:00:00

  • Studies on the clustering of multiple sclerosis in Finland I: Comparison between the domiciles and places of birth in selected subpopulations.

    abstract::Further studies pm yjr rofr,op;phu pg ,i;yo;r dv;rtpdod (MS) IN Finland were carried out in three different types of geographical unit: in counties, combined clerical districts, and single clerical district. For longitudinal studies, the prevalence of MS by present domicile was compared to that by place of birth, and ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1975.tb01362.x

    authors: Wikström J,Palo J

    更新日期:1975-02-01 00:00:00

  • Improvement in verbal memory after withdrawal of carbamazepine and valproate in patients with well-controlled epilepsy: a randomized, double-blind study.

    abstract:BACKGROUND:For most major antiepileptic drugs, neuropsychological side effects have been reported. Healthy volunteer studies have found that both carbamazepine and valproate impair aspects of verbal memory. OBJECTIVE:The aim of this study was to assess the effects of carbamazepine and valproate on verbal memory, in a ...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1600-0404.2010.01452.x

    authors: Hessen E,Lossius MI,Gjerstad L

    更新日期:2011-06-01 00:00:00

  • Experimental facial myokymia in cat.

    abstract:INTRODUCTION:The objective of this study was to describe facial myokymia in experimental animals accompanying kainic acid affects on facial motor neurons. MATERIAL & METHODS:Anesthetized cats were injected with kainic acid into the pons adjacent to the facial nucleus. Facial movements appeared shortly after the inject...

    journal_title:Acta neurologica Scandinavica

    pub_type: 杂志文章

    doi:10.1111/j.1600-0404.1997.tb00062.x

    authors: Zaaroor M,Starr A

    更新日期:1997-01-01 00:00:00

  • The effect of L-Deprenyl on on-off phenomena in Parkinson's disease.

    abstract::L-Deprenyl, a specific monoamine oxidase subtype B inhibitor, has been reported a valuable adjunct to conventional treatment of Parkinsonism. A double-blind cross-over controlled study was performed in 19 parkinsonian patients with on-off type problems. Five mg L-Deprenyl per day reduced the number of on-off episodes....

    journal_title:Acta neurologica Scandinavica

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1600-0404.1985.tb03233.x

    authors: Brodersen P,Philbert A,Gulliksen G,Stigård A

    更新日期:1985-06-01 00:00:00