A review comparing the safety and tolerability of memantine with the acetylcholinesterase inhibitors.

Abstract:

OBJECTIVE:Alzheimer's disease (AD) is prevalent among elderly people, who often have comorbid conditions, and may be prescribed multiple medications. Drug safety and tolerability is paramount in maximising efficacy and optimising patient and carer quality of life, as patients are vulnerable to adverse events (AEs) and/or compliance difficulties. The two principal categories of drug used in the treatment of AD are the acetylcholinesterase inhibitors (AChEIs) and the NMDA-receptor antagonist, memantine. This paper reviews the most recent safety data for memantine in comparison with the AChEIs. DESIGN:Review of most recent safety/tolerability data for memantine and AChEIs, derived from meta-analyses, pooled analyses, European SPCs and EMEA publications. RESULTS:Memantine was found to have a favourable tolerability profile when used as monotherapy or in combination with other agents. AChEIs were found to be fairly well tolerated. All treatments commonly or very commonly produce dizziness and/or headache. AChEIs are associated with many more types of AEs than memantine, particularly in the gastrointestinal category. Agitation is a less common AE when comparing memantine treatment to placebo, but just as common when comparing AChEI treatment to placebo. Withdrawals in memantine-treated groups are comparable to placebo, and more common in AChEI-treated groups compared to placebo. Overall, drug-drug interactions, contraindications and warnings were fewer for memantine than AChEIs. CONCLUSIONS:In both the clinical and naturalistic setting, memantine displays a safety and tolerability profile that is favourable and distinct from that of AChEIs. Safety and tolerability profiles should be given careful consideration when selecting treatment for AD patients.

authors

Jones RW

doi

10.1002/gps.2384

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

547-53

issue

6

eissn

0885-6230

issn

1099-1166

journal_volume

25

pub_type

杂志文章,评审
  • Executive functioning in older adults with hoarding disorder.

    abstract:BACKGROUND:Hoarding disorder (HD) is a chronic and debilitating psychiatric condition. Midlife HD patients have been found to have neurocognitive impairment, particularly in areas of executive functioning, but the extent to which this is due to comorbid psychiatric disorders has not been clear. AIMS/METHOD:The purpose...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.3940

    authors: Ayers CR,Wetherell JL,Schiehser D,Almklov E,Golshan S,Saxena S

    更新日期:2013-11-01 00:00:00

  • A novel hybrid scale for the assessment of cognitive and executive function: The Free-Cog.

    abstract:BACKGROUND:Scales measuring cognitive and executive functions are integral to the assessment and management of patients with suspected cognitive impairment. Some of the most commonly used cognitive tests are now subject to copyright restrictions. Furthermore, no existing scale assesses both executive and cognitive abil...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.5454

    authors: Burns A,Harrison JR,Symonds C,Morris J

    更新日期:2020-10-29 00:00:00

  • Risk factors for symptomatic HIV-associated neurocognitive disorder in adults aged 50 and over attending a HIV clinic in Tanzania.

    abstract:OBJECTIVES:HIV-associated neurocognitive disorder (HAND), although prevalent, remains a poorly researched cause of morbidity particularly in sub-Saharan Africa (SSA). We aimed to explore the risk factors for HAND in people aged 50 and over under regular follow-up at a government HIV clinic in Tanzania. METHODS:HIV-pos...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.5357

    authors: Eaton P,Lewis T,Kellett-Wright J,Flatt A,Urasa S,Howlett W,Dekker M,Kisoli A,Rogathe J,Thornton J,McCartney J,Yarwood V,Irwin C,Mukaetova-Ladinska EB,Akinyemi R,Gray WK,Walker RW,Dotchin CL,Makupa PC,Quaker AS,Pad

    更新日期:2020-06-04 00:00:00

  • Trajectories of quality of life in early-stage dementia: individual variations and predictors of change.

    abstract:BACKGROUND:Little evidence is available about how quality of life (QoL) changes as dementia progresses. OBJECTIVES:We explored QoL trajectories over a 20-month period and examined what predicted change in QoL. METHOD:Fifty-one individuals with a diagnosis of Alzheimer's, vascular or mixed dementia (people with dement...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.4044

    authors: Clare L,Woods RT,Nelis SM,Martyr A,Marková IS,Roth I,Whitaker CJ,Morris RG

    更新日期:2014-06-01 00:00:00

  • An integrative review of acupressure interventions for older people: A focus on sleep quality, depression, anxiety, and agitation.

    abstract:OBJECTIVES:This integrative review aimed to synthesize studies that investigated the effects of acupressure on sleep quality, depression, anxiety, and agitation in older people, and to describe the acupressure procedures and techniques applied in the included studies. METHODS:A literature search was conducted using el...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.5031

    authors: Hmwe NTT,Browne G,Mollart L,Allanson V,Chan SW

    更新日期:2019-03-01 00:00:00

  • Effects of modified 8-week reminiscence therapy on the older spouse caregivers of stroke survivors in Chinese communities: A randomized controlled trial.

    abstract:OBJECTIVE:Our aim was to evaluate the effectiveness of a modified 8-week reminiscence therapy on the burden, positive experience, and life satisfaction of older spouse caregivers and the life satisfaction of stroke survivors. METHODS:We conducted a randomized controlled trial by using 75 older stroke couples recruited...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/gps.4833

    authors: Mei Y,Lin B,Li Y,Ding C,Zhang Z

    更新日期:2018-04-01 00:00:00

  • Old age mental health services in England: implementing the National Service Framework for Older People.

    abstract:BACKGROUND:There is much variation in the services provided for older people with mental health problems. In England, the National Service Framework for Older People (NSFOP) sought to address these inconsistencies and improve care. This study describes the situation three years after its publication. METHODS:A postal ...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.1662

    authors: Tucker S,Baldwin R,Hughes J,Benbow S,Barker A,Burns A,Challis D

    更新日期:2007-03-01 00:00:00

  • Does patient expectancy account for the cognitive and clinical benefits of mindfulness training in older adults?

    abstract:OBJECTIVES:Patient expectations of treatment effects could influence neuropsychological and clinical outcomes in clinical trials of behavioral and lifestyle interventions, which could potentially confound the interpretation of findings. Our aim was to examine whether patient expectancy mediated effectiveness of Mindful...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.5279

    authors: Haddad R,Lenze EJ,Nicol G,Miller JP,Yingling M,Wetherell JL

    更新日期:2020-06-01 00:00:00

  • The association between intensive care unit admission and subsequent depression in patients with diabetes.

    abstract:OBJECTIVE:To examine whether intensive care unit (ICU) admission is independently associated with increased risk of major depression in patients with diabetes. METHODS:This prospective cohort study included 3596 patients with diabetes enrolled in the Pathways Epidemiologic Follow-Up Study, of whom 193 had at least one...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.2684

    authors: Davydow DS,Hough CL,Russo JE,Von Korff M,Ludman E,Lin EH,Ciechanowski P,Young B,Oliver M,Katon WJ

    更新日期:2012-01-01 00:00:00

  • Medication use in nursing homes for elderly people.

    abstract::Residents of nursing and residential homes are often prescribed medication for physical and mental ill-health with resultant polypharmacy and the possibility of iatrogenic disorders. Sometimes drugs are prescribed inappropriately and a number of studies have highlighted the overuse of psychotropic drugs. Legislation i...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章,评审

    doi:10.1002/(sici)1099-1166(199807)13:7<433::aid-gps79

    authors: Furniss L,Craig SK,Burns A

    更新日期:1998-07-01 00:00:00

  • Biomarker counseling, disclosure of diagnosis and follow-up in patients with mild cognitive impairment: A European Alzheimer's disease consortium survey.

    abstract:OBJECTIVES:Mild cognitive impairment (MCI) is associated with an increased risk of further cognitive decline, partly depending on demographics and biomarker status. The aim of the present study was to survey the clinical practices of physicians in terms of biomarker counseling, management, and follow-up in European exp...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.5427

    authors: Frederiksen KS,Nielsen TR,Appollonio I,Andersen BB,Riverol M,Boada M,Ceccaldi M,Dubois B,Engelborghs S,Frölich L,Hausner L,Gabelle A,Gabryelewicz T,Grimmer T,Hanseeuw B,Hort J,Hugon J,Jelic V,Koivisto A,Kramberger M

    更新日期:2021-02-01 00:00:00

  • Performance of a computer-based assessment of cognitive function measures in two cohorts of seniors.

    abstract:BACKGROUND:Computer-administered assessment of cognitive function is being increasingly incorporated in clinical trials; however, its performance in these settings has not been systematically evaluated. DESIGN:The Seniors Health and Activity Research Program pilot trial (N = 73) developed a computer-based tool for ass...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/gps.3949

    authors: Espeland MA,Katula JA,Rushing J,Kramer AF,Jennings JM,Sink KM,Nadkarni NK,Reid KF,Castro CM,Church T,Kerwin DR,Williamson JD,Marottoli RA,Rushing S,Marsiske M,Rapp SR,LIFE Study Group.

    更新日期:2013-12-01 00:00:00

  • Subjective complaints and self-evaluation of memory test performance in Questionable dementia.

    abstract:BACKGROUND:The clinical significance of subjective memory complaints in elderly subjects has been an area of active research. In this study, we evaluated subjective complaints and self-evaluation of memory test performance in subjects with Questionable dementia (QD) and mild Alzheimer's disease (AD). METHODS:Ninety-tw...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.1586

    authors: Wong CH,Lam LC,Lui VW,Chiu HF,Chan SS,Tam CW

    更新日期:2006-10-01 00:00:00

  • Neuropsychiatric disturbance in Alzheimer's disease clusters into three groups: the Cache County study.

    abstract:OBJECTIVE:We investigated the frequency and inter-relationship of neuropsychiatric disturbances in a population sample of persons suffering from Alzheimer's disease (AD). METHOD:Screening 5,092 elderly residents (90% of the population aged 65 and older) of Cache County, Utah, for dementia, we identified 198 persons wi...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.448

    authors: Lyketsos CG,Sheppard JM,Steinberg M,Tschanz JA,Norton MC,Steffens DC,Breitner JC

    更新日期:2001-11-01 00:00:00

  • The effects of aging on insight into illness in schizophrenia: a review.

    abstract:OBJECTIVES:Impaired insight into illness is a prevalent feature of schizophrenia, which negatively influences treatment adherence and clinical outcomes. Little is known about the effects of aging on insight impairment. We aimed to review the available research literature on the effects of aging on insight into illness ...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章,评审

    doi:10.1002/gps.4154

    authors: Gerretsen P,Plitman E,Rajji TK,Graff-Guerrero A

    更新日期:2014-11-01 00:00:00

  • Normative study of the Stroop Color and Word Test in an educationally diverse elderly population.

    abstract:OBJECTIVE:The purpose of this study was to explore the effects of demographic variables on Stroop Color and Word Test (SCWT) performance in an educationally diverse elderly population and to provide normative information. METHODS:SCWT was administered to 564 community-dwelling volunteers aged 60-90 years with an educa...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.2027

    authors: Seo EH,Lee DY,Choo IH,Kim SG,Kim KW,Youn JC,Jhoo JH,Woo JI

    更新日期:2008-10-01 00:00:00

  • Caregivers of people with Alzheimer's disease: a qualitative study from the Indian 10/66 Dementia Research Network.

    abstract:BACKGROUND:Dementia is a rapidly growing problem in all parts of the developing world. Such societies are characterised by low levels of awareness regarding dementia as a chronic degenerative brain syndrome, and by an absence of supportive health and welfare services. There is reliance upon families as the cornerstone ...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.649

    authors: Shaji KS,Smitha K,Lal KP,Prince MJ

    更新日期:2003-01-01 00:00:00

  • Outcome of delirium: Part 1. Outcome of delirium diagnosed by DSM-III-R, ICD-10 and CAMDEX and derivation of the Reversible Cognitive Dysfunction Scale among acute geriatric inpatients.

    abstract:OBJECTIVE:To study performance of DSM-III-R, ICD-10 and CAMDEX diagnoses of delirium as predictors of improvement in mental state in survivors, and to develop a brief rating scale which will predict reversibility of cognitive dysfunction. DESIGN:Prospective cohort study. SETTING:Acute geriatric inpatient units. PATI...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/(sici)1099-1166(199706)12:6<609::aid-gps55

    authors: Treloar AJ,Macdonald AJ

    更新日期:1997-06-01 00:00:00

  • Utility of the Algase Wandering Scale in an outpatient Alzheimer's disease sample.

    abstract:BACKGROUND:Wandering represents a major problem in the management of patients with Alzheimer's disease (AD). In this study we examined the utility of the Algase Wandering Scale (AWS), a newly developed psychometric instrument that asks caregivers to assess the likelihood of wandering behavior. METHODS:The AWS was admi...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.1745

    authors: Marcus JF,Cellar JS,Ansari FP,Bliwise DL

    更新日期:2007-08-01 00:00:00

  • Reliability and validity of the Spanish version of the IDEAL Schedule for assessing care needs in dementia: Cross-sectional, multicenter study.

    abstract:OBJECTIVE:The IDEAL Schedule was developed for staging "care needs" in patients with dementia. We here aim to validate the Spanish version, further test its psychometric properties and explore a latent construct for "care needs". METHODS:A multicenter study was done in 8 dementia care facilities across Spain. Patients...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章,多中心研究

    doi:10.1002/gps.4781

    authors: López-Antón R,Barrada JR,Santabárbara J,Posadas-de Miguel M,Agüera L,Burillo C,Franco M,López-Álvarez J,Mesa P,Petidier R,Quintanilla MÁ,Robles-Del Olmo B,Ventura T,Semrau M,Sartorius N,Lobo A,the members of the IDEAL Spa

    更新日期:2018-03-01 00:00:00

  • Neuropsychiatric symptoms in South-East Asian patients with mild cognitive impairment and dementia: prevalence, subtypes, and risk factors.

    abstract:BACKGROUND:The subtypes and risk factors of neuropsychiatric symptoms remain largely unexplored in South-East Asian populations. OBJECTIVE:We investigated the prevalence, subtypes, and risk factors, namely, demographic, medical morbidity, and cognitive impairment associated with neuropsychiatric symptoms in a South-Ea...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.4693

    authors: Yatawara C,Hiu S,Tan L,Kandiah N

    更新日期:2018-01-01 00:00:00

  • Exploring perspectives of young onset dementia caregivers with high versus low unmet needs.

    abstract:BACKGROUND:This study is part of the Research to Assess Policies and Strategies for Dementia in the Young project. Information about specific needs in young onset dementia (YOD) will provide the basis for the development of an e-health intervention to assist caregivers in coping with YOD in several European countries. ...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.4749

    authors: Millenaar JK,Bakker C,van Vliet D,Koopmans RTCM,Kurz A,Verhey FRJ,de Vugt ME

    更新日期:2018-02-01 00:00:00

  • Comparative effects of risperidone and olanzapine on cognition in elderly patients with schizophrenia or schizoaffective disorder.

    abstract:OBJECTIVE:To examine the effects of risperidone and olanzapine on cognitive functioning in elderly patients with schizophrenia or schizoaffective disorder. METHOD:One hundred seventy-six elderly inpatients and outpatients with schizophrenia or schizoaffective disorder were enrolled in this multicenter, double-blind tr...

    journal_title:International journal of geriatric psychiatry

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1002/gps.929

    authors: Harvey PD,Napolitano JA,Mao L,Gharabawi G

    更新日期:2003-09-01 00:00:00

  • Resilience and social support as protective factors against abuse of patients with dementia: A study on family caregivers.

    abstract:OBJECTIVE:Scientific literature has identified different vulnerability factors associated to abuse in people with dementia (PWD), but little is known about the psychosocial protective variables against abuse. The main objective of this study is to investigate a set of caregiver and patient factors linked to abuse-relat...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.4905

    authors: Serra L,Contador I,Fernández-Calvo B,Ruisoto P,Jenaro C,Flores N,Ramos F,Rivera-Navarro J

    更新日期:2018-08-01 00:00:00

  • Mortality and causes of death in older patients with schizophrenia.

    abstract:OBJECTIVE:The aim of this study was to evaluate mortality and causes of death in older patients with schizophrenia in comparison with the general population. The mortality of patients experiencing relapse was also compared with those in remission. METHODS:The study sample consists of patients (n = 9461) over 65 years ...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.2833

    authors: Talaslahti T,Alanen HM,Hakko H,Isohanni M,Häkkinen U,Leinonen E

    更新日期:2012-11-01 00:00:00

  • The challenge of evaluating mental health services for older people.

    abstract:BACKGROUND:Despite a consensus on the need to expand and improve mental health care for older people, evidence on models of service development is limited. OBJECTIVE:Referring to two case studies, this paper considers how evaluation of service innovations can inform policy and practice. CONCLUSIONS:Evaluation should ...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章,评审

    doi:10.1002/gps.2576

    authors: McCrae N,Banerjee S

    更新日期:2011-06-01 00:00:00

  • Self-reported vision impairment, vision correction, and depressive symptoms among middle-aged and older Chinese: Findings from the China health and retirement longitudinal study.

    abstract:OBJECTIVE:To investigate associations between vision impairment (VI), vision correction (VC) and depressive symptoms among middle-aged and older Chinese. METHODS:22 203 participants aged ≥45 years from China Health and Retirement Longitudinal Study 2011 to 2015 were divided into four self-reported VI categories: no VI...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.5398

    authors: Zhang Q,Cao GY,Yao SS,Wang C,Chen ZS,Hu YH,Xu B

    更新日期:2021-01-01 00:00:00

  • Prevalence of cognitive impairment in the hospitalized elderly.

    abstract::Surveys of older populations reveal rates of senile dementia varying from 5.2% to 25%. The specialist branch of psychiatry dealing with the elderly advocates that services for these patients and their carers should predominantly be based outside hospital. The following study was conducted in Limerick, Ireland before t...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/(sici)1099-1166(199701)12:1<27::aid-gps446

    authors: Hickey A,Clinch D,Groarke EP

    更新日期:1997-01-01 00:00:00

  • CSF biomarkers in delirium: a systematic review.

    abstract:OBJECTIVE:In recent years, there has been a blossoming of studies examining cerebrospinal fluid (CSF) as a method of studying the pathophysiology of delirium. We systematically reviewed the literature for CSF studies in delirium and provide here a summary of the implications for our understanding of delirium pathophysi...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.4720

    authors: Hall RJ,Watne LO,Cunningham E,Zetterberg H,Shenkin SD,Wyller TB,MacLullich AMJ

    更新日期:2018-11-01 00:00:00

  • Antidementia medication use by aged care facility residents with dementia.

    abstract:OBJECTIVES:Little is known about the use of antidementia medications in Australia. Other countries have reported sociodemographic disparities in use. Our objective was to estimate prevalence, duration, and time to initiation of antidementia medication (cholinesterase inhibitors or memantine) among Australians with deme...

    journal_title:International journal of geriatric psychiatry

    pub_type: 杂志文章

    doi:10.1002/gps.5105

    authors: Lind KE,Gray LC,Raban MZ,Georgiou A,Westbrook JI

    更新日期:2019-07-01 00:00:00