Screening and preventive therapy for tuberculosis.

Abstract:

:The tuberculosis (TB) epidemic is well controlled in most developed countries and the focus in these areas has shifted to TB eradication. Transmission within nonendemic areas is limited and most cases of TB result from reactivation of distant (latent) infection. With adequate resources, wide-scale use of preventive therapy can assist to eliminate the pool of latent infection that is required for TB eradication. In contrast, TB control remains poor in many developing countries, especially those worst affected by poverty and the human immunodeficiency virus (HIV) epidemic. In this review the authors critically assess the approach to TB preventive therapy in children and adults, focus on the underlying treatment rationale, discuss available data and identify issues of concern.

journal_name

Clin Chest Med

authors

Marais BJ,Ayles H,Graham SM,Godfrey-Faussett P

doi

10.1016/j.ccm.2009.08.012

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

827-46, x

issue

4

eissn

0272-5231

issn

1557-8216

pii

S0272-5231(09)00088-4

journal_volume

30

pub_type

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