Abstract:
:The inner core of lipopolysaccharide (LPS) structures in Gram-negative bacteria is considered a highly conserved region. The sugar connecting the membrane-associated lipid A moiety with the hydrophilic saccharide moiety, 3-deoxy-alpha-d-manno-oct-2-ulosonic acid (Kdo) is present in every LPS molecule investigated but it may be partially replaced by d-glycero-alpha-d-talo-oct-2-ulosonic acid (Ko). l-Glycero-alpha-d-manno-heptose (Hep) and phosphate residues are part of most but not all LPS structures and additionally, modifications with 4-amino-4-deoxy-beta-l-arabinose (Ara4N) residues occur in some. A number of different glycosyltransferases is involved in the biosynthesis of the inner core region of different lipopolysaccharides. Here, we report the characterization of Kdo transferases, heptosyltransferases and Ara4N transferases from a variety of bacteria.
journal_name
Eur J Cell Bioljournal_title
European journal of cell biologyauthors
Gronow S,Xia G,Brade Hdoi
10.1016/j.ejcb.2009.10.002subject
Has Abstractpub_date
2010-01-01 00:00:00pages
3-10issue
1eissn
0171-9335issn
1618-1298pii
S0171-9335(09)00316-1journal_volume
89pub_type
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journal_title:European journal of cell biology
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journal_title:European journal of cell biology
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journal_title:European journal of cell biology
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journal_title:European journal of cell biology
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