Abstract：
:Henoch-Schönlein purpura is an acute, systemic, immune complex-mediated, leukocytoclastic vasculitis. It is characterized by a triad of palpable purpura (without thrombocytopenia), abdominal pain, and arthritis. Most patients have an antecedent upper respiratory illness. More than 90 percent of Henoch-Schönlein purpura cases occur in children younger than 10 years; however, adults with this condition are more likely to experience complications than children. All patients with Henoch-Schönlein purpura develop a purpuric rash, 75 percent develop arthritis, 60 to 65 percent develop abdominal pain, and 40 to 50 percent develop renal disease. Because Henoch-Schönlein purpura spontaneously resolves in 94 percent of children and 89 percent of adults, supportive treatment is the primary intervention. Oral prednisone at 1 to 2 mg per kg daily for two weeks has been used to treat abdominal and joint symptoms. A meta-analysis found that corticosteroid use in children reduced the mean time to resolution of abdominal pain and decreased the odds of developing persistent renal disease. Early aggressive therapy with high-dose steroids plus immunosuppressants is recommended for patients with severe renal involvement. Long-term prognosis depends on the severity of renal involvement. End-stage renal disease occurs in 1 to 5 percent of patients.
journal_name
Am Fam Physicianjournal_title
American family physicianauthors
Reamy BV,Williams PM,Lindsay TJsubject
Has Abstractpub_date
2009-10-01 00:00:00pages
697-704issue
7eissn
0002-838Xissn
1532-0650journal_volume
80pub_type
杂志文章abstract：:Although many physicians consider constipation a trivial problem, it is one of the most frequent and chronic digestive disorders in the United States, affecting 4.53 million people and causing considerable morbidity. More than $200 million are spent for over-the-counter laxatives and untold millions of dollars are spe...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：1990-11-01 00:00:00
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journal_title：American family physician
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更新日期：2007-12-15 00:00:00
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journal_title：American family physician
pub_type： 杂志文章
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更新日期：1978-04-01 00:00:00
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更新日期：2014-04-01 00:00:00
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journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：2010-12-01 00:00:00
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journal_title：American family physician
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doi：
更新日期：1998-04-15 00:00:00
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更新日期：2005-01-15 00:00:00
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更新日期：2011-08-15 00:00:00
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doi：
更新日期：2007-03-15 00:00:00
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journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：1981-11-01 00:00:00
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journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：2000-09-15 00:00:00
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journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：2018-01-01 00:00:00
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journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：1976-08-01 00:00:00
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journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：1995-12-01 00:00:00
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journal_title：American family physician
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doi：
更新日期：2007-05-01 00:00:00
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journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：1980-04-01 00:00:00
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journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：1977-07-01 00:00:00
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journal_title：American family physician
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pub_type： 指南,杂志文章,评审
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更新日期：1990-12-01 00:00:00
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journal_title：American family physician
pub_type： 杂志文章
doi：
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journal_title：American family physician
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doi：
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journal_title：American family physician
pub_type： 杂志文章,评审
doi：
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journal_title：American family physician
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journal_title：American family physician
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journal_title：American family physician
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journal_title：American family physician
pub_type： 杂志文章,评审
doi：
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