Abstract:
UNLABELLED:We previously demonstrated correlation between parasympathetic dysfunction and brain white matter lesions in chronic chagasic patients. OBJECTIVE:To correlate serum functional circulating antibodies with beta adrenergic (Ab-beta), muscarinic (Ab-M) or muscarinic and beta adrenergic (Ab-Mbeta) activity, the autonomic system function and brain lesions in chronic chagasic patients. METHOD:In fifteen consecutive chagasic patients, the autonomic nervous system was evaluated and brain magnetic resonance imaging (MRI) was performed. The sera of all patients were tested to the presence of circulating functional antibodies. RESULTS:Sera from 11 of 15 chronic chagasic patients had some activity (Ab-beta: 7; Ab-M: 1; Ab-Mbeta: 3); however, there was no significant correlation between the presence of antibodies and the autonomic system function or the presence of hyperintensities in MRI. CONCLUSION:The mechanism involved in the genesis of hyperintense lesions seen in brain MRI of chronic chagasic patients is still unresolved, although apparently related to parasympathetic dysfunction.
journal_name
Arq Neuropsiquiatrjournal_title
Arquivos de neuro-psiquiatriaauthors
Py MO,Maciel L,Pedrosa RC,Nascimento JH,Medei Edoi
10.1590/s0004-282x2009000400011subject
Has Abstractpub_date
2009-09-01 00:00:00pages
633-8issue
3Aeissn
0004-282Xissn
1678-4227pii
S0004-282X2009000400011journal_volume
67pub_type
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