The presence of antiautonomic membrane receptor antibodies do not correlate with brain lesions in Chagas' disease.

Abstract:

UNLABELLED:We previously demonstrated correlation between parasympathetic dysfunction and brain white matter lesions in chronic chagasic patients. OBJECTIVE:To correlate serum functional circulating antibodies with beta adrenergic (Ab-beta), muscarinic (Ab-M) or muscarinic and beta adrenergic (Ab-Mbeta) activity, the autonomic system function and brain lesions in chronic chagasic patients. METHOD:In fifteen consecutive chagasic patients, the autonomic nervous system was evaluated and brain magnetic resonance imaging (MRI) was performed. The sera of all patients were tested to the presence of circulating functional antibodies. RESULTS:Sera from 11 of 15 chronic chagasic patients had some activity (Ab-beta: 7; Ab-M: 1; Ab-Mbeta: 3); however, there was no significant correlation between the presence of antibodies and the autonomic system function or the presence of hyperintensities in MRI. CONCLUSION:The mechanism involved in the genesis of hyperintense lesions seen in brain MRI of chronic chagasic patients is still unresolved, although apparently related to parasympathetic dysfunction.

journal_name

Arq Neuropsiquiatr

authors

Py MO,Maciel L,Pedrosa RC,Nascimento JH,Medei E

doi

10.1590/s0004-282x2009000400011

subject

Has Abstract

pub_date

2009-09-01 00:00:00

pages

633-8

issue

3A

eissn

0004-282X

issn

1678-4227

pii

S0004-282X2009000400011

journal_volume

67

pub_type

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