[Late effects on the hypothalamo-pituitary function after the treatment of parasellar tumors].

Abstract:

:Long term follow-up of patients submitted to treatment of parasellar tumours region is important for the detection of late therapeutic complications. In this study the authors conducted an evaluation of six patients with craniopharyngioma, one with germinoma, one with meningioma, and one epidermoid cyst. All above tumours were localized at parasellar region. Six out of nine patients had been treated both by surgery and by radiotherapy and the other three surgically only, on an average 3.8 +/- 3.2 years before this observation was carried out. Five patients were female with their ages average 24.3 +/- 18.8 years old. Evaluation consisted: in the first place, an intravenous infusion of thyrotropin-releasing hormone (TRH, 200 micrograms), gonadotropin-releasing hormone (GnRH, 100 micrograms), and insulin tolerance test (0.1 IU/Kg, regular insulin); and secondly, in measurements of pituitary hormones secretion at different time points--0, 20, 40, 60 and 80 minutes. We found both diminished response of growth hormone and cortisol in all the patients. Seven out of nine patients did not have adequate response to follicle-stimulating hormone. Three out of nine responded unsatisfactory to luteinizing hormone. Four out of nine showed inadequate responses to prolactin as well as, two out of eight to thyrotropin. We concluded that: (a) growth hormone and cortisol deficiency are the most frequent finding in these patients; (b) post-radiotherapy lesions can be located in the hypothalamus or pituitary, or even in both; (c) hypophysial and hypothalamic cells sensitivity to irradiation is different, according to their respective hormones; and (d) it is necessary a frequent endocrinologic follow-up of patients to detect late hormonal deficiencies.

journal_name

Arq Neuropsiquiatr

authors

Da Motta LA,Martinelli C,Da Motta LD,Abrahão AL,Farage Filho M,Gagliardi AR

doi

10.1590/s0004-282x1991000300011

subject

Has Abstract

pub_date

1991-09-01 00:00:00

pages

299-306

issue

3

eissn

0004-282X

issn

1678-4227

journal_volume

49

pub_type

杂志文章
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    journal_title:Arquivos de neuro-psiquiatria

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  • Invasive medullary thymoma associated with Myasthenia gravis: an unusual case.

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  • [Congenital myotonia. Report of 7 patients].

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    journal_title:Arquivos de neuro-psiquiatria

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    doi:10.1590/s0004-282x1996000400008

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  • [Correlation between corticospinal tract degeneration through magnetic resonance imaging, and functional scale (ALSFRS) in patients with amyotrophic lateral sclerosis].

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    更新日期:2007-06-01 00:00:00

  • Anticoagulation in patients with cardiac manifestations of Chagas disease and cardioembolic ischemic stroke.

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    journal_title:Arquivos de neuro-psiquiatria

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    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章,评审

    doi:10.1590/s0004-282x1996000200019

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  • The presence of antiautonomic membrane receptor antibodies do not correlate with brain lesions in Chagas' disease.

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    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章

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  • Demonstration project on epilepsy in Brazil: outcome assessment.

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    pub_type: 杂志文章

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  • Environmental air pollution is an aggravating event for sudden unexpected death in epilepsy.

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    journal_title:Arquivos de neuro-psiquiatria

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  • Psychiatric symptoms are present in most of the patients with idiopathic normal pressure hydrocephalus.

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    更新日期:2014-06-01 00:00:00

  • [Electroencephalographic evolution in women with refractory epilepsy].

    abstract::We reviewed 444 EEGs of 62 women with medically refractory epilepsy, followed up for at least 5 years and that had 5 or more EEGs. According to our definitions we found 18 patients (29%) with frequent seizures, 16 (25.8%) with very frequent seizures, 16 (25.8%) with controlled seizures and 12 (19.3%) with occasional s...

    journal_title:Arquivos de neuro-psiquiatria

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    更新日期:1995-09-01 00:00:00

  • [Postoperative complications in 139 cases of basilar impression and/or Arnold-Chiari deformity].

    abstract::The many kinds of complication that have been observed following operations of basilar impression and/or malformation of Arnold-Chiari are analysed. Two surgical techniques were adopted in the treatment of the patients. In the first 64 cases, the operation consisted in the craniectomy of the posterior fossa and high c...

    journal_title:Arquivos de neuro-psiquiatria

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    更新日期:1981-09-01 00:00:00

  • [Recurrent bacterial meningitis].

    abstract::The study of CSF fistulae, and especially those involving otolaryngological anomalies, must be based on the search for the causative problem of recurrent meningitis. Congenital malformations, post-traumatic and post-operative situations or even diseases involving the cranial bones are basic causes that should be studi...

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    pub_type: 杂志文章,评审

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    更新日期:1992-06-01 00:00:00

  • Neuromuscular transmission studies in human chronic Chagas' disease.

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    journal_title:Arquivos de neuro-psiquiatria

    pub_type: 杂志文章

    doi:10.1590/s0004-282x1989000300004

    authors: Erro MG,Genovese O,Correale J,Sica RE

    更新日期:1989-09-01 00:00:00

  • Translation and cultural adaptation of the Game Dice Task to Brazilian population.

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    pub_type: 临床试验,杂志文章

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  • Sleep habits in native Brazilian Terena children in the state of Mato Grosso do Sul, Brazil.

    abstract::Sleep habits in childhood vary in function of physiological factors. Cultural traits also influence sleep habits. This research evaluates sleep habits of Native Brazilian Terena children. The Terena group here studied live in the central region of Mato Grosso do Sul, Brazil, on the plains; they are peaceful and dedica...

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    更新日期:1998-12-01 00:00:00

  • [Increase of interleukin-2 soluble receptors in multiple sclerosis: preliminary study in 26 patients].

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    pub_type: 杂志文章

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    更新日期:1994-06-01 00:00:00

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    abstract::The authors describe the extraordinary contribution to science made by José Dantas de Souza Leite, who graduated from the Bahia School of Medicine and trained in Prof. Charcot's Neurology Service under the supervision of Charcot's most able pupil, Dr. Pierre Marie. Souza Leite presented his doctoral thesis on acromega...

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  • [Phasic activity of REM sleep in newborns and infants and its relationship with apnea episodes].

    abstract::When the apnea hypothesis turned to be an explanation for sudden infant death syndrome (SIDS) many authors tried to find if near-miss or apparent life-threatening events (ALTE) could be markers of SIDS. It was suggested that phasic REM activity is associated with increased respiratory neuron activity and prevents prol...

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    pub_type: 杂志文章

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    更新日期:1997-06-01 00:00:00