Ketogenic diet for the treatment of refractory epilepsy: a 10 year experience in children.

Abstract:

:Ketogenic diet (KD) is a high fat and low carbohydrate diet, which controls refractory epilepsy. We analyzed the KD effects on 54 children of the Children's Institute of the University of São Paulo. Efficacy, tolerability, and adverse effects were studied. Response to KD was effective (E) if seizure control was >75%, good (G) when 50-75%. When possible, we correlated the results with the epileptic syndrome and patient's age. By the second month on diet, 57.4% of the patients had E response and 31.4% G results. At the 6th month, 63.8% had E response and 25.5% G. At the 12th month, 71.8% had E and 25.6% G. At the 24th month, 62.1% had E and 37.9% G. Antiepileptic drugs have been reduced, and generalized epilepsy was the most sensitive. Age-related differences were not observed. Adverse effects were rarely observed. In conclusion, KD proved to be an effective treatment for refractory epilepsy.

journal_name

Arq Neuropsiquiatr

authors

Freitas A,Paz JA,Casella EB,Marques-Dias MJ

doi

10.1590/s0004-282x2007000300003

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

381-4

issue

2B

eissn

0004-282X

issn

1678-4227

pii

S0004-282X2007000300003

journal_volume

65

pub_type

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