The initial hemodynamic response to newer antihypertensive agents at rest and during exercise: review of visacor, doxazosin, nisoldipine, tiapamil, perindoprilat, pinacidil, dilevalol, and carvedilol.

abstract：:Left ventricular dysfunction is in most cases the consequence of myocardial ischemia. It may occur transiently during an attack of angina and usually it is reversible. It may persist over hours or even days in patients after an episode of ischemia followed by reperfusion, leading to the so-called condition of stunning...

journal_title：Cardiovascular drugs and therapy

authors： Ferrari R,La Canna G,Giubbini R,Milan E,Ceconi C,de Giuli F,Berra P,Alfieri O,Visioli O

更新日期：1994-05-01 00:00:00

abstract：INTRODUCTION:Most circulating fatty acids are contained in lipoprotein triglycerides. For the heart to acquire these lipids, they must be broken down into free fatty acids via the enzyme lipoprotein lipase (LpL). Although it has long been known that hearts primarily use esterified fatty acids as fuel, different sources...

journal_title：Cardiovascular drugs and therapy

authors： Noh HL,Yamashita H,Goldberg IJ

更新日期：2006-12-01 00:00:00

abstract：PURPOSE:To compare the lifetime cost and effectiveness of five alternative chronic atrial fibrillation (AF) management strategies: rivaroxaban, warfarin, aspirin plus clopidogrel, aspirin and no prevention. METHODS:An individual-level state-transition model was developed to track the lifetime disease course associated...

journal_title：Cardiovascular drugs and therapy

authors： Wu B,Kun L,Liu X,He B

更新日期：2014-02-01 00:00:00

abstract：PURPOSE:Treatment of pulmonary arterial hypertension (PAH) by vasodilator drug monotherapy is often limited in its effectiveness. Combination therapy may help to improve treatment and to reduce drug toxicity. This study assessed the combination of the endothelin receptor antagonist macitentan and the phosphodiesterase-...

journal_title：Cardiovascular drugs and therapy

authors： Hoenicka M,Golovchenko S,Englert L,Spaeth M,Shoshiashvili L,Großer C,Hofmann HS,Ried M

更新日期：2019-06-01 00:00:00

abstract：:Elgodipine is a new second-generation dihydropyridine calcium antagonist. Its hemodynamic and antiischemic properties were evaluated in a single-blind, placebo-controlled trial in 22 males with chronic stable angina. Coronary artery disease was angiographically confirmed. Measurements were performed with a Swan-Ganz t...

journal_title：Cardiovascular drugs and therapy

authors： Kuhn A,Carlsson J,Miketic S,Tebbe U

更新日期：1995-08-01 00:00:00

abstract：PURPOSE:The benefits of statin treatment initiated in advanced age are largely unknown; however, good adherence to treatment is essential for beneficial effects to be achieved also when treating older people. This study characterizes older statin initiators, including their cardiovascular risk profiles and morbidity, a...

journal_title：Cardiovascular drugs and therapy

authors： Upmeier E,Korhonen MJ,Rikala M,Helin-Salmivaara A,Huupponen R

更新日期：2014-06-01 00:00:00

abstract：:The purpose of the study was to determine whether a new KATP channel opener, Y 26763 (Y), can influence the electrophysiological properties in the ischemic myocardium as well as to determine whether the blunting effect of the alpha 1-adrenoceptor antagonist bunazosin (BN) on an ischemia-induced shortening of repolariz...

journal_title：Cardiovascular drugs and therapy

authors： Tanabe T,Aikawa M,Deguchi Y,Yoshioka K,Handa S

更新日期：2000-06-01 00:00:00

abstract：:Piperanometozine (OPC-8212) is a new, orally effective inotropic agent. To evaluate the efficacy of this agent on systemic hemodynamics and clinical symptoms in patients with congestive heart failure, a multicenter study was performed. Thirty four patients with New York Heart Association (NYHA) functional classes II t...

journal_title：Cardiovascular drugs and therapy

authors： Inoue M,Hori M,Yasuda H,Takishima T,Sugimoto T,Sasayama S,Sakurai T,Nonogi H,Kodama K,Kusukawa R

更新日期：1987-08-01 00:00:00

abstract：PURPOSE:Epidemiologic and clinical research suggests important gender-related differences in the prevalence, presentation, associated conventional and non-conventional risk factors, management and outcomes of coronary heart disease (CHD) patients. Adequate data is not available for Indian population where prevalence of...

journal_title：Cardiovascular drugs and therapy

authors： Bhatt P,Parikh P,Patel A,Parikh R,Patel A,Mehta JL,Parikh K

更新日期：2015-08-01 00:00:00

abstract：:We compared the time-course of the hemodynamic effect of isosorbide dinitrate (ISDN), 5 mg, in the form of sublingual tablet and oral spray, in 15 patients with isolated chronic pulmonary congestion (pulmonary arterial end-diastolic pressure of 15 mmHg or more in the presence of normal or only slightly reduced cardiac...

journal_title：Cardiovascular drugs and therapy

authors： Marchionni N,De Bari M,Ferrucci L,Moschi G,Schneeweiss A

更新日期：1988-11-01 00:00:00

abstract：INTRODUCTION:Surrogate markers represent a significant contribution to early diagnosis, longitudinal prognoses, and outcome prediction in cases of hypertension. They often enable detection of disease and disease potential when the disease is still subclinical and are useful noninvasive tools for designing and evaluatin...

journal_title：Cardiovascular drugs and therapy

authors： Maisel AS

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:Heart failure (HF) is considered to be a prothrombotic condition and it has been suggested that coagulation factors contribute to maladaptive cardiac remodelling via activation of the protease-activated receptor 1 (PAR1). We tested the hypothesis that anticoagulation with the factor Xa (FXa) inhibitor apixab...

journal_title：Cardiovascular drugs and therapy

authors： Yurista SR,Silljé HHW,Nijholt KT,Dokter MM,van Veldhuisen DJ,de Boer RA,Westenbrink BD

更新日期：2020-05-26 00:00:00

abstract：:Recent surveys in the U.S. have reported, for the first time, that a significant number of patients with hypertension are finding that the cost of medication and treatment in general is an obstacle to treatment. The cost of management of hypertension can be contained if: a) the diagnostic workup is kept simple (this d...

journal_title：Cardiovascular drugs and therapy

authors： Moser M

更新日期：1989-10-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate the impact of granulocyte-colony stimulating factor (G-CSF) administration on cardiac function of rats with chronic myocardial infarction through two different protocols: high dose short term and low dose long term protocols. METHODS:Wistar rats were submitted to MI sur...

journal_title：Cardiovascular drugs and therapy

authors： Louzada RA,Oliveira PF,Cavalcanti-de-Albuquerque JP,Cunha-Carvalho L,Baldanza MR,Kasai-Brunswick TH,Goldenberg RC,Campos-de-Carvalho AC,Werneck-de-Castro JP

更新日期：2010-04-01 00:00:00

abstract：:Colesevelam hydrochloride (colesevelam) is a novel, potent, bile acid-binding agent that has been shown to lower LDL cholesterol a mean of 19% at a dose of 3.8 g/d. We studied the pharmacokinetics of colesevelam coadministered with six drugs: digoxin and warfarin, agents with narrow therapeutic indices; sustained-rele...

journal_title：Cardiovascular drugs and therapy

authors： Donovan JM,Stypinski D,Stiles MR,Olson TA,Burke SK

更新日期：2000-12-01 00:00:00

abstract：PURPOSE:To assess the effects of electro-acupuncture (EA) on glycemic control, myocardial inflammation, and the progression of diabetic cardiomyopathy in mice with type 2 diabetes. METHODS:Db/Db mice received EA at PC6+ST36 (DM-Acu), non-acupoint simulation (DM-Sham), or no treatment (DM). EA was applied for 30 min pe...

journal_title：Cardiovascular drugs and therapy

authors： Ye Y,Birnbaum Y,Widen SG,Zhang Z,Zhu S,Bajaj M,Chen H

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Although Takotsubo syndrome (TS) was once considered to be rare and largely benign, it is now recognized to represent a major cause of cardiac morbidity and mortality, especially in ageing women. The biochemical precipitant of attacks of TS is an increase in catecholamine concentrations within the myocardium...

journal_title：Cardiovascular drugs and therapy

authors： Ong GJ,Nguyen TH,Stansborough J,Surikow SY,Horowitz JD

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Markers of thrombosis, inflammation, endothelial dysfunction and neurohumoral activation such as fibrinogen, D-dimer, C-reactive protein, von Willebrand factor, tumour necrosis factor-alpha and chromogranin-A are reported to be linked to the increase of cardiovascular risk for atherosclerosis progression and...

journal_title：Cardiovascular drugs and therapy

authors： Scientific Committee of the PERTINENT Sub-Study, EUROPA-PERTINENT Investigators.

更新日期：2003-01-01 00:00:00

abstract：:To assess the effect of antihypertensive drugs on aortic distensibility, we evaluated the aortic distensibility of 33 hypertensive patients before and after antihypertensive treatment by using cine magnetic resonance imaging. Thirty three hypertensive patients were divided into three groups and treated for 12 weeks wi...

journal_title：Cardiovascular drugs and therapy

authors： Honda T,Hamada M,Shigematsu Y,Matsumoto Y,Matsuoka H,Hiwada K

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVE:Percutaneous vascular interventions lead inevitably to a destruction of the endothelial lining at the site of injury. There are conflicting data on the therapeutic benefit of hematopoietic growth factors aiming at mobilisation of circulating endothelial cells to accelerate the reendothelialisation process. Ai...

journal_title：Cardiovascular drugs and therapy

authors： Hack M,Mascha FG,Jobst BJ,Riegger GA,Griese DP

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:The use of sodium-glucose co-transporter 2 inhibitors (SGLT2i) is currently expanding to cardiovascular risk reduction in non-diabetic subjects, but renal (side-)effects are less well studied in this setting. METHODS:Male non-diabetic Sprague Dawley rats underwent permanent coronary artery ligation to induc...

journal_title：Cardiovascular drugs and therapy

authors： Yurista SR,Silljé HHW,van Goor H,Hillebrands JL,Heerspink HJL,de Menezes Montenegro L,Oberdorf-Maass SU,de Boer RA,Westenbrink BD

更新日期：2020-06-01 00:00:00

abstract：:The cardiovascular effects and safety of transdermal nicotine patches were assessed in 50 healthy smokers using repeated 48 hour ambulatory electrocardiographic monitoring as a part of a smoking cessation program. Following baseline measurements, subjects were randomized to active (n = 25) or placebo (n = 25) treatmen...

journal_title：Cardiovascular drugs and therapy

authors： Khoury Z,Comans P,Keren A,Lerer T,Gavish A,Tzivoni D

更新日期：1996-05-01 00:00:00

abstract：:Of 17 patients with mild to moderate essential hypertension, 8 showed echocardiographic evidence of left ventricular hypertrophy. Cardiac and renal function evaluated by glomerular filtration rate (GFR) were studied in all patients before and after 20 weeks of quinapril treatment. Systolic pressure decreased from 174....

journal_title：Cardiovascular drugs and therapy

authors： De Caprio L,De Rosa ML,Di Palma A,Lirato C,Caccese P,Sestito M,Lastoria S,Cicatiello AM,Rengo F

更新日期：1994-10-01 00:00:00

abstract：:The novel insights provided by the molecular genetic applied to the study of cardiac arrhythmias have just started to scratch the surface of the complex relationships between the genetic abnormalities of ion channel structure and the susceptibility to life threatening ventricular arrhythmias. These crucial pieces of i...

journal_title：Cardiovascular drugs and therapy

authors： Priori SG,Napolitano C

更新日期：2002-03-01 00:00:00

abstract：PURPOSE:Treatment of atherosclerotic rabbits with intravenous methotrexate or etoposide carried in lipid nanoemulsions (LDE) markedly reduced the lesions in the aorta. Here, the combined treatment with LDE-methotrexate and LDE-etoposide was investigated aiming to increase the anti-atherosclerosis effect. METHODS:Thirt...

journal_title：Cardiovascular drugs and therapy

authors： Leite AC Jr,Solano TV,Tavares ER,Maranhão RC

更新日期：2015-02-01 00:00:00

abstract：PURPOSE:In addition to lowering hemoglobin A1C, colesevelam has been shown to improve the atherogenic lipoprotein profile of subjects with type 2 diabetes mellitus (T2DM) when used in combination with metformin and/or sulfonylureas. A recent study evaluated the effects of colesevelam as antidiabetes monotherapy in adul...

journal_title：Cardiovascular drugs and therapy

authors： Rosenson RS,Rigby SP,Jones MR,Chou HS

更新日期：2014-06-01 00:00:00

abstract：:The present study was undertaken on 10 patients with angina undergoing percutaneous transluminal coronary angioplasty. The angioplasty procedure consisted of two successive 30-second balloon inflations at 5 minute intervals. After the first inflation, nicorandil (0.1 mg/kg) was given intravenously over a 2-minute peri...

journal_title：Cardiovascular drugs and therapy

authors： Saito S,Mizumura T,Takayama T,Honye J,Fukui T,Kamata T,Moriuchi M,Hibiya K,Tamura Y,Ozawa Y

更新日期：1995-03-01 00:00:00

abstract：:The present study was designed to evaluate the effects of oral verapamil and normal diet on regression of atherosclerotic plaque in cholesterol fed rabbits. Forty-three rabbits were separated into 6 groups and studied for 24 weeks. All groups had a cholesterol diet for the first 12 weeks. Group I was then sacrificed a...

journal_title：Cardiovascular drugs and therapy

authors： Sievers RE,Rashid T,Garrett J,Blumlein S,Parmley WW

更新日期：1987-01-01 00:00:00

abstract：:Quality of life in heart failure patients is receiving increased attention as a reflection of a treatment's potential secondary benefit of general well-being and daily functioning. The Metoprolol in Dilated Cardiomyopathy (MDC) trial was conducted as a large, multicenter trial to establish the effects of metoprolol on...

journal_title：Cardiovascular drugs and therapy

authors： Wiklund I,Waagstein F,Swedberg K,Hjalmarsson A

更新日期：1996-07-01 00:00:00

abstract：:With the increased use of long-acting nitroglycerin preparations, there has been greater recognition of the problem of nitrate tolerance. In recent years extensive research has broadened our understanding of the mechanisms of nitroglycerin action and the mechanisms of drug attenuation. This paper reviews the current s...

journal_title：Cardiovascular drugs and therapy

authors： Katz RJ

更新日期：1990-02-01 00:00:00