Regression of left ventricular hypertrophy and improvement of renal hemodynamics in hypertensive patients treated with quinapril.

abstract：PURPOSE:The glucose-lowering drug metformin has recently been shown to reduce myocardial oxygen consumption and increase myocardial efficiency in chronic heart failure (HF) patients without diabetes. However, it remains to be established whether these beneficial myocardial effects are associated with metformin-induced ...

journal_title：Cardiovascular drugs and therapy

authors： Larsen AH,Wiggers H,Dollerup OL,Jespersen NR,Hansson NH,Frøkiær J,Brøsen K,Nørrelund H,Bøtker HE,Møller N,Jessen N

更新日期：2020-08-08 00:00:00

abstract：:In animal models, calcium antagonists (Ca-A) administered before ischemia and reperfusion reduced myocardial necrosis, attenuated postischemic contractile dysfunction, and reduced tissue calcium. In 753 patients with acute myocardial infarction (AMI), we examined if use of Ca-A at the onset of symptoms (n = 127 patien...

journal_title：Cardiovascular drugs and therapy

authors： Landmark K,Abdelnoor M,Kilhovd B,Dørum HP

更新日期：1997-09-01 00:00:00

abstract：:The effects of nifedipine on left ventricular function were evaluated in 17 patients with coronary artery disease with an ambulatory radionuclide detector (VEST). Hemodynamic data were recorded continuously at rest and during upright bicycle ergometer exercise before and 30 minutes after 10 mg of oral nifedipine admin...

journal_title：Cardiovascular drugs and therapy

authors： Kambara H,Mohiuddin IH,Tamaki N,Fudo T,Hayashi M,Nohara R,Konishi J,Kawai C

更新日期：1990-08-01 00:00:00

abstract：PURPOSE:The benefits of statin treatment initiated in advanced age are largely unknown; however, good adherence to treatment is essential for beneficial effects to be achieved also when treating older people. This study characterizes older statin initiators, including their cardiovascular risk profiles and morbidity, a...

journal_title：Cardiovascular drugs and therapy

authors： Upmeier E,Korhonen MJ,Rikala M,Helin-Salmivaara A,Huupponen R

更新日期：2014-06-01 00:00:00

abstract：PURPOSE:The glucagon-like peptide-1 (GLP-1) has been shown to exert cardioprotective effects in animals and patients. This study tests the hypothesis that preservation of GLP-1 by the GLP-1 receptor agonist liraglutide or the dipeptidyl peptidase-4 (DPP-4) inhibitor linagliptin is associated with a reduction of angiote...

journal_title：Cardiovascular drugs and therapy

authors： Zhang LH,Pang XF,Bai F,Wang NP,Shah AI,McKallip RJ,Li XW,Wang X,Zhao ZQ

更新日期：2015-06-01 00:00:00

abstract：:This study compares the electrophysiologic effects of amlodipine and diltiazem in patients with coronary artery disease concomitantly treated with background beta-blocking therapy. Thirty patients were included in an open-label parallel study in two phases. During phase 1, patients were screened and placed on maintena...

journal_title：Cardiovascular drugs and therapy

authors： Santarelli P,Biscione F,Natale A,Manzoli A,Lanza GA

更新日期：1994-08-01 00:00:00

abstract：:Ouabain, when applied to rings of the left circumflex coronary artery of the dog (which contains both alpha 1-adrenoceptors leading to contraction and beta 1-adrenoceptors leading to relaxation) caused an initial contraction which peaked within 15 minutes and a later secondary increase in tension which peaked within 6...

journal_title：Cardiovascular drugs and therapy

authors： Cooke JP,Shepherd JT,Vanhoutte PM

更新日期：1988-07-01 00:00:00

abstract：:Thrombolytic therapy has gained widespread acceptance as a means of treating coronary artery thrombosis in patients with acute myocardial infarction. Although experimental data have demonstrated that timely reperfusion limits the extent of infarction caused by regional ischemia, there is growing evidence that reperfus...

journal_title：Cardiovascular drugs and therapy

authors： Werns SW,Lucchesi BR

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:Hypothyroidism (HT) is associated with accelerated atherosclerosis (AS). The efficacy of traditional strategies of hypothyroid AS remains controversial. Here, we aimed to deepen the understanding of the HT-induced acceleration of AS, to decrease the residual risk of coronary artery disease (CAD) and to find a n...

journal_title：Cardiovascular drugs and therapy

authors： Yang Y,Jia Y,Ning Y,Wen W,Qin Y,Zhang H,Du Y,Li L,Jiao X,Yang Y,Liu G,Huang M,Zhang M

更新日期：2020-06-03 00:00:00

abstract：RATIONALE:Pulmonary hypertension (PH) represents a serious health complication accompanied with hypoxic conditions, elevated levels of asymmetric dimethylarginine (ADMA), and overall dysfunction of pulmonary vascular endothelium. Since the prevention strategies for treatment of PH remain largely unknown, our study aime...

journal_title：Cardiovascular drugs and therapy

authors： Koudelka A,Ambrozova G,Klinke A,Fidlerova T,Martiskova H,Kuchta R,Rudolph TK,Kadlec J,Kuchtova Z,Woodcock SR,Freeman BA,Kubala L,Pekarova M

更新日期：2016-12-01 00:00:00

abstract：:A survey of the pharmacokinetic properties of the three prototypical calcium antagonist agents shows that they have in common a very high rate of hepatic first-pass metabolism with, in the case of verapamil and diltiazem, the formation of an active metabolite that affects the dose during chronic therapy. Therefore, th...

journal_title：Cardiovascular drugs and therapy

authors： Opie LH

更新日期：1989-08-01 00:00:00

abstract：:Major advances have been established in the handling of hypertensive vascular disease in recent years. However, drug compliance, drug costs, and the side effects of antihypertensive agents have prompted the question of whether intermittent therapy or even possible removal of medication represents an alternative to lif...

journal_title：Cardiovascular drugs and therapy

authors： Schmieder RE,Rockstroh JK

更新日期：1990-12-01 00:00:00

abstract：:Cardiovascular diseases are of fundamental importance in the cause of death and morbidity in the elderly as a group. If the successful management of blood pressure can effect a reduction in morbid events as well as death, as has been indicated by recent trials, the elderly have more to gain than any other group within...

journal_title：Cardiovascular drugs and therapy

authors： Dall JL

更新日期：1991-01-01 00:00:00

abstract：:Cholesterol plays an essential role in cell membrane synthesis and in cell growth and differentiation. In mammalian cells, cholesterol can be synthesized from acetate precursors or taken up from dietary or exogenous sources. The major catabolic route for disposal of cholesterol involves conversion into excretable bile...

journal_title：Cardiovascular drugs and therapy

authors： Russell DW

更新日期：1992-04-01 00:00:00

abstract：:There is considerable evidence implicating a key role for p38 mitogen-activated protein kinase (MAPK) in ischemic and pharmacological preconditioning against myocardial infarction. However, there have been few, if any, studies examining the role of p38 MAPK in the protection of stunned myocardium. The purpose of this ...

journal_title：Cardiovascular drugs and therapy

authors： Yoshimura Y,Kristo G,Keith BJ,Jahania SA,Mentzer RM Jr,Lasley RD

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Acute ST-elevation myocardial infarction (STEMI) is associated with a high incidence of complications as well as a considerable hospitalization rate and economic burden. Preliminary evidence suggests that remote ischemic conditioning (RIC) is a promising non-invasive intervention that may effectively and saf...

journal_title：Cardiovascular drugs and therapy

authors： Zheng Y,Reinhardt JD,Li J,Hu D,Lin S,Wang L,Dai R,Fan Z,Ding R,Chen L,Yuan L,Xu Z,Cheng Y,Yan C,Zhang X,Wang L,Zhang X,Teng M,Yu Q,Yin A,Lu X,i-RIC Trial Collaboration Group.

更新日期：2020-06-30 00:00:00

abstract：INTRODUCTION:During and following cardiac ischemia the levels of circulating fatty acids are elevated, resulting in fatty acid oxidation dominating as a source of oxidative metabolism at the expense of pyruvate oxidation. A decrease in the levels of myocardial malonyl-CoA (an endogenous inhibitor of mitochondrial fatty...

journal_title：Cardiovascular drugs and therapy

authors： Lopaschuk GD,Stanley WC

更新日期：2006-12-01 00:00:00

abstract：:We used Folts' model of critical coronary artery stenosis with endothelial damage, which measures platelet-rich thrombus accumulation from cyclic flow reductions (CFRs). This paper reports results applied to trimetazidine, a member of the piperazine group. Trimetazidine at a dose of 1 mg/kg completely abolished CFRs c...

journal_title：Cardiovascular drugs and therapy

authors： Belcher PR,Drake-Holland AJ,Hynd JW,Noble MI

更新日期：1993-02-01 00:00:00

abstract：:Intravenous amiodarone has been found useful in the emergent management of life-threatening arrhythmias. Experimental studies have shown that its electrophysiologic effects are proportional to its myocardial concentration. However, early after its intravenous administration, the extent of the concentration of amiodaro...

journal_title：Cardiovascular drugs and therapy

authors： Anastasiou-Nana MI,Nanas JN,Alexopoulos G,Karli JN,Margari ZJ,Agapitos E,Patsi EN,Stamatelopoulos SF

更新日期：1999-05-01 00:00:00

abstract：PURPOSE:Although erythropoietin (EPO) is known to express angiogenic and cardioprotective effects, it also induces hypertension, polycythemia, and platelet activation, which may cause serious adverse effects in patients with cardiovascular diseases. We compared the angiogenic effects of EPO and its nonerythropoietic de...

journal_title：Cardiovascular drugs and therapy

authors： Yanagawa T,Toba K,Kato K,Suzuki T,Minagawa S,Saigawa T,Ozawa T,Oda M,Takayama T,Hanawa H,Higuchi M,Saito H,Aizawa Y

更新日期：2013-04-01 00:00:00

abstract：:A succession of theories arising from last century has attempted to explain why patients with damaged hearts develop peripheral edema. Opposed to the original simple concepts of backward failure, a number of theories of forward failure have been proposed, the cardiac output being considered inadequate for capillary pe...

journal_title：Cardiovascular drugs and therapy

authors： Harris P

更新日期：1994-06-01 00:00:00

abstract：PURPOSE:Morphine has been used for several decades in cases of acute pulmonary edema (APE) due to the anxiolytic and vasodilatory properties of the drug. The non-specific depression of the central nervous system is probably the most significant factor for the changes in hemodynamics in APE. Retrospective studies have s...

journal_title：Cardiovascular drugs and therapy

authors： Dominguez-Rodriguez A,Burillo-Putze G,Garcia-Saiz MDM,Aldea-Perona A,Harmand MG,Mirò O,Abreu-Gonzalez P,MIMO investigators.

更新日期：2017-04-01 00:00:00

abstract：:The calcium antagonist (CA) controversy has been fueled in part by disagreements among scientists and clinicians over the scientific documentation required for drugs used to treat lifelong conditions. From a public health perspective, there are three unanswered questions: (1) Does long-term use of CAs convey health be...

journal_title：Cardiovascular drugs and therapy

authors： Furberg CD,Psaty BM

更新日期：1996-09-01 00:00:00

abstract：:Cardiovascular disease is the leading cause of death in men and women in the USA. Once a patient experiences an acute coronary syndrome (ACS), they are at increased risk for hospital readmission within 30 days and 6 months after discharge and more importantly, they have worse survival. Hospital readmissions lead to po...

journal_title：Cardiovascular drugs and therapy

authors： Paruchuri V,Gaztanaga J,Rambhujun V,Smith R,Farkouh ME

更新日期：2018-12-01 00:00:00

abstract：:Levosimendan, a calcium sensitizer and potassium channel-opener, is widely appreciated by many specialist heart failure practitioners for its effects on systemic and pulmonary hemodynamics and for the relief of symptoms of acute heart failure. The drug's impact on mortality in large randomized controlled trials has be...

journal_title：Cardiovascular drugs and therapy

authors： Bouchez S,Fedele F,Giannakoulas G,Gustafsson F,Harjola VP,Karason K,Kivikko M,von Lewinski D,Oliva F,Papp Z,Parissis J,Pollesello P,Pölzl G,Tschöpe C

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:This study aimed to investigate the cost-effectiveness of low-dose rivaroxaban plus aspirin versus aspirin alone for patients with stable cardiovascular diseases in the Taiwan setting. METHODS:We constructed a Markov model to project the lifetime direct medical costs and quality-adjusted life-years of both the...

journal_title：Cardiovascular drugs and therapy

authors： Lee MC,Liao CT,Toh HS,Chou CC,Chang WT,Chen ZC,Wu WS,Yu T,Strong C

更新日期：2020-09-10 00:00:00

abstract：PURPOSE:To investigate the associations of diuretics overall, non-potassium-sparing diuretics in specific, and laxative use with cardiovascular mortality (CVM) in subjects with antihypertensive treatment. METHODS:Analyses included 4253 participants, aged 50 to 75 years, from the German ESTHER cohort and 105,359 partic...

journal_title：Cardiovascular drugs and therapy

authors： Hoppe LK,Muhlack DC,Koenig W,Brenner H,Schöttker B

更新日期：2019-10-01 00:00:00

abstract：AIMS:We evaluated a generic quality of life (QoL) Functional Status Questionnaire (FSQ), in patients with chronic heart failure (CHF). The FSQ assesses the 3 main dimensions of QoL: physical functioning, mental health and social role. It also includes 6 single item questions about: work status, frequency of social inte...

journal_title：Cardiovascular drugs and therapy

authors： Gallanagh S,Castagno D,Wilson B,Erdmann E,Zannad F,Remme WJ,Lopez-Sendon JL,Lechat P,Follath F,Höglund C,Mareev V,Sadowski Z,Seabra-Gomes RJ,Dargie HJ,McMurray JJ

更新日期：2011-02-01 00:00:00

abstract：:Encainide is a class 1C antiarrhythmic agent that is indicated for the treatment of life-threatening arrhythmias, such as sustained ventricular tachycardia. Furthermore, encainide possesses a moderate degree of antiserotonin activity, which was quantitated in this present study by determining displacement of [3H]spipe...

journal_title：Cardiovascular drugs and therapy

authors： Fleming JS,Buchanan JO,Yocca FD,Iben LG,Antonaccio MJ

更新日期：1991-08-01 00:00:00

abstract：:The antihypertensive effects of once-daily administration of celiprolol 400 mg were compared with those of once-daily enalapril 20 mg in 20 mild to moderate essential hypertensives in a single-blind study in which the subjects were randomized to 2 weeks' treatment with either drug, preceded by 2 weeks of placebo admin...

journal_title：Cardiovascular drugs and therapy

authors： Ghiringhelli S,Cozzi E,Tsialtas D

更新日期：1988-07-01 00:00:00