Cost-effectiveness of different strategies for stroke prevention in patients with atrial fibrillation in a health resource-limited setting.

abstract：:To compare the antiischemic effects of intracoronary administration of a beta blocker, atenolol, and of a calcium antagonist, nifedipine, on the clinical and electrocardiographic signs of myocardial ischemia induced by balloon occlusion of the coronary artery, we studied 32 consecutive patients undergoing routine PTCA...

journal_title：Cardiovascular drugs and therapy

authors： Ghio S,De Servi S,Angoli L,Bramucci E,Eleuteri E,Raffaghello S,Specchia G

更新日期：1992-06-01 00:00:00

abstract：:ATP generates nitric oxide (NO) via activation of P2y receptors, and is degraded to adenosine. This study was undertaken to examine whether ATP causes coronary hyperemic flow via purinoceptors-, NO- and adenosine-dependent mechanisms, and attenuates the severity of contractile and metabolic dysfunction in the ischemic...

journal_title：Cardiovascular drugs and therapy

authors： Kitakaze M,Node K,Komamura K,Minamino T,Kosaka H,Kuzuya T,Hori M

更新日期：1999-09-01 00:00:00

abstract：:To further evaluate the significance of p38 MAPK as trigger or mediator in ischaemic preconditioning, anisomycin and SB 203580 were used to manipulate its activation status. Special attention was given to the concentration of the drugs and protocols used. The isolated perfused rat heart, subjected to either 25 min glo...

journal_title：Cardiovascular drugs and therapy

authors： Lochner A,Genade S,Hattingh S,Marais E,Huisamen B,Moolman JA

更新日期：2003-05-01 00:00:00

abstract：:A survey of the pharmacokinetic properties of the three prototypical calcium antagonist agents shows that they have in common a very high rate of hepatic first-pass metabolism with, in the case of verapamil and diltiazem, the formation of an active metabolite that affects the dose during chronic therapy. Therefore, th...

journal_title：Cardiovascular drugs and therapy

authors： Opie LH

更新日期：1989-08-01 00:00:00

abstract：:Milrinone is shown in 10 patients to be a valuable pharmacological bridge to heart transplantation; it can stabilize and improve decompensated chronic heart failure (CHF) in cases where the response to beta-agonists is inadequate. One patient who had suffered an acute myocardial infarction with heart failure resistant...

journal_title：Cardiovascular drugs and therapy

authors： Sherry KM,Locke TJ

更新日期：1993-08-01 00:00:00

abstract：OBJECTIVE:Percutaneous vascular interventions lead inevitably to a destruction of the endothelial lining at the site of injury. There are conflicting data on the therapeutic benefit of hematopoietic growth factors aiming at mobilisation of circulating endothelial cells to accelerate the reendothelialisation process. Ai...

journal_title：Cardiovascular drugs and therapy

authors： Hack M,Mascha FG,Jobst BJ,Riegger GA,Griese DP

更新日期：2008-10-01 00:00:00

abstract：PURPOSE:The glucose-lowering drug metformin has recently been shown to reduce myocardial oxygen consumption and increase myocardial efficiency in chronic heart failure (HF) patients without diabetes. However, it remains to be established whether these beneficial myocardial effects are associated with metformin-induced ...

journal_title：Cardiovascular drugs and therapy

authors： Larsen AH,Wiggers H,Dollerup OL,Jespersen NR,Hansson NH,Frøkiær J,Brøsen K,Nørrelund H,Bøtker HE,Møller N,Jessen N

更新日期：2020-08-08 00:00:00

abstract：:We studied the acute and chronic effects of propionyl-L-carnitine (PLC) on mechanical function of isolated rabbit heart. Propionyl-L-carnitine was either directly delivered in the perfusate (10(-9) to 10(-3) M) or intraperitoneally injected (250 mg/kg) for 10 days to the animals. When added acutely, propionyl-L-carnit...

journal_title：Cardiovascular drugs and therapy

authors： Ferrari R,Pasini E,Condorelli E,Boraso A,Lisciani R,Marzo A,Visiou O

更新日期：1991-02-01 00:00:00

abstract：PURPOSE:Morphine has been used for several decades in cases of acute pulmonary edema (APE) due to the anxiolytic and vasodilatory properties of the drug. The non-specific depression of the central nervous system is probably the most significant factor for the changes in hemodynamics in APE. Retrospective studies have s...

journal_title：Cardiovascular drugs and therapy

authors： Dominguez-Rodriguez A,Burillo-Putze G,Garcia-Saiz MDM,Aldea-Perona A,Harmand MG,Mirò O,Abreu-Gonzalez P,MIMO investigators.

更新日期：2017-04-01 00:00:00

abstract：:To evaluate cordiodepressive risks of antiarrhythmic treatment with diprafenone, we monitored, in addition to conventional hemodynamic parameters, end-systolic pressure-volume relations to assess potential negative inotropic effects. Thirteen patients underwent hemodynamic analysis with and without the influence of di...

journal_title：Cardiovascular drugs and therapy

authors： Thormann J,Kramer W,Kremer P,Schlepper M

更新日期：1989-04-01 00:00:00

abstract：:Chronic renal failure (CRF) patients with a stable course were asked to participate in a follow-up program in which they were randomized into two groups: 1) the placebo group taking their standard antihypertensive therapy without any calcium ion blocker: and 2) the nisoldipine group, those patients taking the calcium ...

journal_title：Cardiovascular drugs and therapy

authors： Eliahou HE,Cohen D,Ben-David A,Herzog D,Serban I,Gavendo S,Kapuler S,Kogan N,Hellberg B

更新日期：1988-01-01 00:00:00

abstract：:Colesevelam hydrochloride (colesevelam) is a novel, potent, bile acid-binding agent that has been shown to lower LDL cholesterol a mean of 19% at a dose of 3.8 g/d. We studied the pharmacokinetics of colesevelam coadministered with six drugs: digoxin and warfarin, agents with narrow therapeutic indices; sustained-rele...

journal_title：Cardiovascular drugs and therapy

authors： Donovan JM,Stypinski D,Stiles MR,Olson TA,Burke SK

更新日期：2000-12-01 00:00:00

abstract：:Calcium channel blockers are a group of drugs used for the treatment of hypertension. Carbonic anhydrase (CA) I detected in vascular smooth muscle and in other cells in the organism has a major role in the acid-base balance and in vascular processes. Our previous work has proven that verapamil inhibits CA activity by ...

journal_title：Cardiovascular drugs and therapy

authors： Puscas L,Gilau L,Coltau M,Pasca R,Domuta G,Baican M,Hecht A

更新日期：2000-10-01 00:00:00

abstract：:The combination of aspirin and clopidogrel is the mainstay antiplatelet therapy for acute coronary syndromes (ACS). However, the dosing of aspirin, the dosing of clopidogrel, the timing of clopidogrel initiation as well as the duration of clopidogrel therapy remain controversial matters. Clopidogrel resistance is an e...

journal_title：Cardiovascular drugs and therapy

authors： Hanna EB,Glancy DL,Saucedo JF

更新日期：2010-02-01 00:00:00

abstract：:Twenty-nine patients with severe heart failure (NYHA III) were randomly assigned to receive therapy with an angiotensin converting enzyme inhibitor (ACE inhibitor), either captopril or enalapril. The mean daily dosage of captopril was 56 +/- 5 mg and of enalapril 9.5 +/- 0.4 mg. After a mean of 8 +/- 1 days, the influ...

journal_title：Cardiovascular drugs and therapy

authors： Osterziel KJ,Dietz R,Harder K,Kübler W

更新日期：1992-04-01 00:00:00

abstract：:The effects of orally administered captopril, enalapril and lisinopril on plasma concentrations of angiotensin converting enzyme (ACE), angiotensin II (ANGII) and renin (PRC) were studied over a period of 6 hours in 6 normal subjects. A further 4 subjects received intravenous enalapril and enalaprilic acid (enalaprila...

journal_title：Cardiovascular drugs and therapy

authors： Semple PF,Cumming AM,Meredith PA,Morton JJ

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:Permanent polymer drug-eluting stents (DES) are associated with a higher risk of late and very late stent thrombosis (ST); biodegradable polymer drug-eluting stents (BP-DES) were designed to reduce these risks. However, their benefits are not completely clear. METHOD:We undertook a meta-analysis of randomize...

journal_title：Cardiovascular drugs and therapy

authors： Wang Y,Dong P,Li L,Li X,Wang H,Yang X,Wang S,Li Z,Shang X

更新日期：2014-08-01 00:00:00

abstract：:Quality of life in heart failure patients is receiving increased attention as a reflection of a treatment's potential secondary benefit of general well-being and daily functioning. The Metoprolol in Dilated Cardiomyopathy (MDC) trial was conducted as a large, multicenter trial to establish the effects of metoprolol on...

journal_title：Cardiovascular drugs and therapy

authors： Wiklund I,Waagstein F,Swedberg K,Hjalmarsson A

更新日期：1996-07-01 00:00:00

abstract：:Specific antiarrhythmic therapy with class I and III drugs for atrial fibrillation (AF) conversion and prevention of its recurrence is frequently utilized in clinical practice. Besides being only moderate effective, the utilization of antiarrhythmic drugs may be associated with serious side effects. In the clinical se...

journal_title：Cardiovascular drugs and therapy

authors： Husser D,Stridh M,Sornmo L,Platonov P,Olsson SB,Bollmann A

更新日期：2004-09-01 00:00:00

abstract：PURPOSE:Homocysteine (Hcy) is an independent risk factor for cardiovascular diseases that impairs endothelial function. We investigated whether the impaired endothelial function can be restored by the eNOS transcription enhancer AVE3085 in porcine coronary arteries. The effects of AVE3085 against Hcy on eNOS-NO functio...

journal_title：Cardiovascular drugs and therapy

authors： Yang Q,Xue HM,Underwood MJ,Yu CM

更新日期：2013-12-01 00:00:00

abstract：:Heart rate varies with respiration, blood pressure, emotion, etc., and heart rate variability (HRV) is presently one of the best indices to predict fatal issues in cardiac failure and after myocardial infarction. HRV depends on various reflexes. In addition, parallel studies of HRV and the myocardial adrenergic and mu...

journal_title：Cardiovascular drugs and therapy

authors： Swynghedauw B,Jasson S,Chevalier B,Clairambault J,Hardouin S,Heymes C,Mangin L,Mansier P,Médigue C,Moalic JM,Thibault N,Carré F

更新日期：1997-01-01 00:00:00

abstract：:Annual mortality from congestive heart failure ranges from 15% to 60%, depending on the severity of the left ventricular damage and underlying disease. Most controlled trials have been too small to detect any beneficial effect on survival from the newer vasodilator and inotropic drugs. However, the results of two rece...

journal_title：Cardiovascular drugs and therapy

authors： Meinertz T,Drexler H,Just H

更新日期：1988-11-01 00:00:00

abstract：:The majority of calcium antagonists used clinically belong to three distinct chemical classes: the phenylalkylamines, the dihydropyridines, and the benzothiazepines. In recent years their mode of action has been unravelled, their limitations recognized, and their efficacy and use in the management of patients with a b...

journal_title：Cardiovascular drugs and therapy

authors： Ferrari R,Cucchini F,Bolognesi R,Bachetti T,Boraso A,Bernocchi P,Gaia G,Visioli O

更新日期：1994-08-01 00:00:00

abstract：:Though the exact physiology and pathology of lipoprotein(a) [Lp(a)] remains unknown, it has been demonstrated that increased serum Lp(a) levels are correlated with an increased risk of atherosclerotic vascular disease. The effects of lipid-lowering drugs on Lp(a) levels is unclear because of inconsistencies between st...

journal_title：Cardiovascular drugs and therapy

authors： Dobs AS,Prasad M,Goldberg A,Guccione M,Hoover DR

更新日期：1995-10-01 00:00:00

abstract：:Mitochondrial health is critically dependent on the ability of mitochondria to undergo changes in mitochondrial morphology, a process which is regulated by mitochondrial shaping proteins. Mitochondria undergo fission to generate fragmented discrete organelles, a process which is mediated by the mitochondrial fission p...

journal_title：Cardiovascular drugs and therapy

authors： Ong SB,Kalkhoran SB,Hernández-Reséndiz S,Samangouei P,Ong SG,Hausenloy DJ

更新日期：2017-02-01 00:00:00

abstract：:In two separate, double-blind, multicenter antiarrhythmic studies, sotalol was compared with propranolol or quinidine using placebo for baseline and/or washout periods. The comparison with quinidine was a crossover study. To be enrolled in these studies, patients were required to have a premature ventricular contracti...

journal_title：Cardiovascular drugs and therapy

authors： Hanyok JJ,MacNeil DJ

更新日期：1990-06-01 00:00:00

abstract：:Pulmonary arterial hypertension is a rare disease, with drug-induced causes even more uncommon, accounting for only 10% of cases in large registry series. Predisposing factors for drug-induced PAH have not been completely defined. This review summarizes drugs with definite, possible, or likely association to pulmonary...

journal_title：Cardiovascular drugs and therapy

authors： Correale M,Tricarico L,Grazioli D,Formica ES,Petrucci R,Persichella P,Di Biase M,Brunetti ND

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:Treatment of pulmonary arterial hypertension (PAH) by vasodilator drug monotherapy is often limited in its effectiveness. Combination therapy may help to improve treatment and to reduce drug toxicity. This study assessed the combination of the endothelin receptor antagonist macitentan and the phosphodiesterase-...

journal_title：Cardiovascular drugs and therapy

authors： Hoenicka M,Golovchenko S,Englert L,Spaeth M,Shoshiashvili L,Großer C,Hofmann HS,Ried M

更新日期：2019-06-01 00:00:00

abstract：PURPOSE:Hypothyroidism (HT) is associated with accelerated atherosclerosis (AS). The efficacy of traditional strategies of hypothyroid AS remains controversial. Here, we aimed to deepen the understanding of the HT-induced acceleration of AS, to decrease the residual risk of coronary artery disease (CAD) and to find a n...

journal_title：Cardiovascular drugs and therapy

authors： Yang Y,Jia Y,Ning Y,Wen W,Qin Y,Zhang H,Du Y,Li L,Jiao X,Yang Y,Liu G,Huang M,Zhang M

更新日期：2020-06-03 00:00:00

abstract：:Amlodipine increases NO levels in coronary vessels and aorta via bradykinin-dependent mechanisms in vitro. We have previously reported that a long-acting Ca channel blocker, benidipine, increases cardiac NO levels in ischemic canine hearts, suggesting that benidipine may also protect against ischemia and reperfusion i...

journal_title：Cardiovascular drugs and therapy

authors： Asanuma H,Kitakaze M,Node K,Takashima S,Sakata Y,Asakura M,Sanada S,Shinozaki Y,Mori H,Tada M,Kuzuya T,Hori M

更新日期：2001-01-01 00:00:00