Onset of action of captopril, enalapril, enalaprilic acid and lisinopril in normal man.

abstract：PURPOSE:Protein kinase C alpha (gene: PRKCA) is a key regulator of cardiac contractility. Two genetic variants have recently been discovered to regulate PRKCA expression in failing human heart tissue (rs9909004 [T → C] and rs9303504 [C → G]). The association of those variants with clinical outcomes in patients with hea...

journal_title：Cardiovascular drugs and therapy

authors： Luzum JA,Ting C,Peterson EL,Gui H,Shugg T,Williams LK,Li L,Sadee W,Wang D,Lanfear DE

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:To evaluate whether aleglitazar (Ale), a dual PPARα/γ agonist, has additive effects on myocardial protection against ischemia-reperfusion injury. METHODS:Human cardiomyocytes (HCMs), cardiomyocytes from cardiac-specific PPARγ knockout (MCM-PPARγ (CKO) ) or wild type (MCM-WT) mice were incubated with different ...

journal_title：Cardiovascular drugs and therapy

authors： Qian J,Chen H,Birnbaum Y,Nanhwan MK,Bajaj M,Ye Y

更新日期：2016-04-01 00:00:00

abstract：:As damage to the pulmonary vascular endothelium may be responsible for the lung toxicity of amiodarone, we evaluated the cytolytic toxicity of the drug in cultures of endothelial cells. Cells were cultured from human umbilical cord veins. Amiodarone caused a vacuolization of the cells with liberation of both lactate d...

journal_title：Cardiovascular drugs and therapy

authors： Baudin B,Bénéteau-Burnat B,Giboudeau J

更新日期：1996-11-01 00:00:00

abstract：OBJECTIVE:The natural history of pediatric patients with severely symptomatic neurocardiogenic syncope is poorly defined respect to the likelihood of remission or symptomatic recurrence along time. We undertook this study to investigate the likelihood of clinical relapse, and to assess the effect of prophylactic pharma...

journal_title：Cardiovascular drugs and therapy

authors： Biffi M,Boriani G,Bronzetti G,Frabetti L,Picchio FM,Branzi A

更新日期：2001-03-01 00:00:00

abstract：:Despite continuous advances in myocardial revascularization procedures and intracoronary devices, patients with ischemic heart disease (IHD) still experience worse prognosis and poor quality of life (QoL). Indeed, chronic stable angina (CSA) is a common disease with a large burden on healthcare costs. Traditionally, C...

journal_title：Cardiovascular drugs and therapy

authors： Guarini G,Huqi A,Morrone D,Marzilli M

更新日期：2016-08-01 00:00:00

abstract：:The use of calcium antagonists and diuretics in combination for treatment of hypertension is controversial. In a single-blind study 16 patients (8 men, 8 women, age range 39 to 62 years) with primary hypertension of mild to moderate degree were given slow-release nifedipine 20 mg twice daily for 6 weeks, thereafter ei...

journal_title：Cardiovascular drugs and therapy

authors： Ferrara LA,Marotta T,Pasanisi F,Mastranzo P,Mancini M

更新日期：1988-03-01 00:00:00

abstract：:People who consume a diet rich in fruit and vegetables have lower risks of cancer, cardiovascular disease and all-cause mortality. Many prospective cohort studies have reported inverse associations between dietary intake or blood levels of beta-carotene and risks of cancer. Several large-scale trials were set up to as...

journal_title：Cardiovascular drugs and therapy

authors： Clarke R,Armitage J

更新日期：2002-09-01 00:00:00

abstract：:We used Folts' model of critical coronary artery stenosis with endothelial damage, which measures platelet-rich thrombus accumulation from cyclic flow reductions (CFRs). This paper reports results applied to trimetazidine, a member of the piperazine group. Trimetazidine at a dose of 1 mg/kg completely abolished CFRs c...

journal_title：Cardiovascular drugs and therapy

authors： Belcher PR,Drake-Holland AJ,Hynd JW,Noble MI

更新日期：1993-02-01 00:00:00

abstract：:Excess activity of the sympathetic nervous system (SNS) is linked to human obese hypertension and to salt-sensitive hypertension. Paradoxically, reduced SNS activity has been implicated as a contributor to obesity, particularly in animal models, and salt loading usually inhibits SNS activity. We have investigated the ...

journal_title：Cardiovascular drugs and therapy

authors： Ernsberger P,Koletsky RJ,Collins LA,Bedol D

更新日期：1996-06-01 00:00:00

abstract：:Mivazerol, 3-[1(H-imidazol-4-yl)methyl]-2-hydroxybenzamide hydrochloride, is a selective alpha 2-adrenoceptor agonist designed for the prevention of myocardial infarction in perioperative patients. Because unintended hypothermia occurs frequently during surgery, we were interested, in this study, to examine the relati...

journal_title：Cardiovascular drugs and therapy

authors： Kim SY,Raikoff K,Wülfert E,Hanin I

更新日期：1997-12-01 00:00:00

abstract：:In order to compare and clarify the effects of various antiarrhythmic drugs when given as monotherapy, we reevaluated our previous data on antiarrhythmic drugs and recalculated antiarrhythmic plasma concentrations of drugs for several canine arrhythmia models. We used three spontaneously occurring arrhythmias: a) digi...

journal_title：Cardiovascular drugs and therapy

authors： Hashimoto K,Haruno A,Matsuzaki T,Sugiyama A,Akiyama K

更新日期：1991-08-01 00:00:00

abstract：BACKGROUND:The use of sodium-glucose co-transporter 2 inhibitors (SGLT2i) is currently expanding to cardiovascular risk reduction in non-diabetic subjects, but renal (side-)effects are less well studied in this setting. METHODS:Male non-diabetic Sprague Dawley rats underwent permanent coronary artery ligation to induc...

journal_title：Cardiovascular drugs and therapy

authors： Yurista SR,Silljé HHW,van Goor H,Hillebrands JL,Heerspink HJL,de Menezes Montenegro L,Oberdorf-Maass SU,de Boer RA,Westenbrink BD

更新日期：2020-06-01 00:00:00

abstract：:Patients with mild to moderate hypertension (diastolic blood pressure > or = 95 and < or = 115 mmHg) and renal dysfunction entered one of two studies to assess the safety of efficacious daily doses of quinapril on renal function and blood pressure. Twenty-four patients with moderate renal impairment (MRI) (creatinine ...

journal_title：Cardiovascular drugs and therapy

authors： Miller MA,Texter M,Gmerek A,Robbins J,Shurzinske L,Canter D

更新日期：1994-04-01 00:00:00

abstract：PURPOSE:This study aimed to investigate the cost-effectiveness of low-dose rivaroxaban plus aspirin versus aspirin alone for patients with stable cardiovascular diseases in the Taiwan setting. METHODS:We constructed a Markov model to project the lifetime direct medical costs and quality-adjusted life-years of both the...

journal_title：Cardiovascular drugs and therapy

authors： Lee MC,Liao CT,Toh HS,Chou CC,Chang WT,Chen ZC,Wu WS,Yu T,Strong C

更新日期：2020-09-10 00:00:00

abstract：:Left ventricular dysfunction is in most cases the consequence of myocardial ischemia. It may occur transiently during an attack of angina and usually it is reversible. It may persist over hours or even days in patients after an episode of ischemia followed by reperfusion, leading to the so-called condition of stunning...

journal_title：Cardiovascular drugs and therapy

authors： Ferrari R,La Canna G,Giubbini R,Milan E,Ceconi C,de Giuli F,Berra P,Alfieri O,Visioli O

更新日期：1994-05-01 00:00:00

abstract：:In animal models, calcium antagonists (Ca-A) administered before ischemia and reperfusion reduced myocardial necrosis, attenuated postischemic contractile dysfunction, and reduced tissue calcium. In 753 patients with acute myocardial infarction (AMI), we examined if use of Ca-A at the onset of symptoms (n = 127 patien...

journal_title：Cardiovascular drugs and therapy

authors： Landmark K,Abdelnoor M,Kilhovd B,Dørum HP

更新日期：1997-09-01 00:00:00

abstract：:Despite the fact that beta blockers were introduced into clinical practice 25 years ago, new beta blockers with differing kinetic and dynamic profiles continue to be developed and marketed. This overview assesses some of the more extensively studied agents from the point of view of proof of utility and the validity of...

journal_title：Cardiovascular drugs and therapy

authors： Fitzgerald JD

更新日期：1991-06-01 00:00:00

abstract：INTRODUCTION:Several beta blocking drugs (BB) reduce mortality in systolic heart failure (LVSD). We have compared the initial response to introduction of carvedilol and bisoprolol during the standard dose titration protocols for each drug. METHODS:Approximately 31 unselected patients with stable LVSD were randomised t...

journal_title：Cardiovascular drugs and therapy

authors： Hamaad A,Lip GY,Nicholls D,MacFadyen RJ

更新日期：2007-12-01 00:00:00

abstract：:Angiotensin converting enzyme inhibitors have greatly improved the treatment of patients with chronic heart failure but they are not effective in all patients, and their use may be limited by side effects. There is, therefore, a need to investigate new drugs and to compare their efficacy with angiotensin converting en...

journal_title：Cardiovascular drugs and therapy

authors： Cowley AJ,Wynne RD,Swami A,Birkhead J,Skene A,Hampton JR

更新日期：1992-10-01 00:00:00

abstract：:The vasorelaxant activity of the omega-3 fatty acids--docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids--in comparison with other known vasodilators--sodium nitroprusside, nitroglycerin, papaverine, and D600--were studied in the isolated rat aorta. The relaxant responses of these vasodilators and fatty acids at c...

journal_title：Cardiovascular drugs and therapy

authors： Engler MB

更新日期：1992-12-01 00:00:00

abstract：INTRODUCTION:Atrial dilatation is commonly associated with atrial fibrillation (AF), but the electrophysiological mechanisms and the implications for anti-arrhythmic therapy are poorly understood. In a model of acute stretch-related AF in isolated rabbit hearts, we evaluated the electrophysiological effects of three di...

journal_title：Cardiovascular drugs and therapy

authors： Kalifa J,Bernard M,Gout B,Bril A,Cozma D,Laurent P,Chalvidan T,Deharo JC,Djiane P,Cozzone P,Maixent JM

更新日期：2007-02-01 00:00:00

abstract：INTRODUCTION:Surrogate markers represent a significant contribution to early diagnosis, longitudinal prognoses, and outcome prediction in cases of hypertension. They often enable detection of disease and disease potential when the disease is still subclinical and are useful noninvasive tools for designing and evaluatin...

journal_title：Cardiovascular drugs and therapy

authors： Maisel AS

更新日期：2009-08-01 00:00:00

abstract：:Major advances have been established in the handling of hypertensive vascular disease in recent years. However, drug compliance, drug costs, and the side effects of antihypertensive agents have prompted the question of whether intermittent therapy or even possible removal of medication represents an alternative to lif...

journal_title：Cardiovascular drugs and therapy

authors： Schmieder RE,Rockstroh JK

更新日期：1990-12-01 00:00:00

abstract：PURPOSE:The prevalence and consequences of prediabetic dysglycemia and undiagnosed diabetes is unknown in patients with heart failure (HF) and preserved ejection fraction (HFpEF) and has not been compared to heart failure and reduced ejection fraction (HFrEF). METHODS:We examined the prevalence and outcomes associated...

journal_title：Cardiovascular drugs and therapy

authors： Kristensen SL,Jhund PS,Lee MMY,Køber L,Solomon SD,Granger CB,Yusuf S,Pfeffer MA,Swedberg K,McMurray JJV,CHARM Investigators and Committees.

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:To determine the association between low molecular weight heparin (LMWH) use and mortality in hospitalized COVID-19 patients. METHODS:We conducted a retrospective study of patients consecutively enrolled from two major academic hospitals exclusively for COVID-19 in Wuhan, China, from January 26, 2020, to March...

journal_title：Cardiovascular drugs and therapy

authors： Shen L,Qiu L,Liu D,Wang L,Huang H,Ge H,Xiao Y,Liu Y,Jin J,Liu X,Wang DW,Peterson ED,He B,Zhou N

更新日期：2021-01-04 00:00:00

abstract：:Encainide is a class IC antiarrhythmic agent having little or no effect on action-potential duration or maximum diastolic potential but decreasing the maximum rate of phase O depolarization as well as increasing atrial and ventricular effective refractory periods. In intact animals or humans, encainide increases the A...

journal_title：Cardiovascular drugs and therapy

authors： Antonaccio MJ,Gomoll AW,Byrne JE

更新日期：1989-10-01 00:00:00

abstract：:In this review we attempt to determine the role of calcium channel blockers in preventing cardiovascular sequelae in patients with both hypertension and diabetes mellitus. The data have been collected from three sources: post-hoc analyses of subgroups of diabetic patients in placebo-controlled hypertension trials (SHE...

journal_title：Cardiovascular drugs and therapy

authors： Gasowski J,Birkenhäger WH,Staessen JA,de Leeuw PW

更新日期：2000-02-01 00:00:00

abstract：:Investment in cardiovascular drug development is on the decline as large cardiovascular outcomes trials require considerable investments in time, efforts and financial resources. Pharmacogenomics has the potential to help revive the cardiovascular drug development pipeline by providing new and better drug targets at a...

journal_title：Cardiovascular drugs and therapy

authors： Dubé MP,de Denus S,Tardif JC

更新日期：2016-02-01 00:00:00

abstract：:The novel insights provided by the molecular genetic applied to the study of cardiac arrhythmias have just started to scratch the surface of the complex relationships between the genetic abnormalities of ion channel structure and the susceptibility to life threatening ventricular arrhythmias. These crucial pieces of i...

journal_title：Cardiovascular drugs and therapy

authors： Priori SG,Napolitano C

更新日期：2002-03-01 00:00:00

abstract：PURPOSE:The glucagon-like peptide-1 (GLP-1) has been shown to exert cardioprotective effects in animals and patients. This study tests the hypothesis that preservation of GLP-1 by the GLP-1 receptor agonist liraglutide or the dipeptidyl peptidase-4 (DPP-4) inhibitor linagliptin is associated with a reduction of angiote...

journal_title：Cardiovascular drugs and therapy

authors： Zhang LH,Pang XF,Bai F,Wang NP,Shah AI,McKallip RJ,Li XW,Wang X,Zhao ZQ

更新日期：2015-06-01 00:00:00