当前位置： SCI文献检索 > CLINICAL AND EXPERIMENTAL IMMUNOLOGY期刊下所有文献 > Inhibition of matrix metalloproteinase-9 activity improves coronary outcome in an animal model of Kawasaki disease.

Inhibition of matrix metalloproteinase-9 activity improves coronary outcome in an animal model of Kawasaki disease.

Abstract：

:Kawasaki disease (KD) is the leading cause of acquired heart disease of children in North America. It is characterized by a massive immune activation and multi-system vasculitis, which evolves into a site-specific inflammatory response focused at the coronary arteries. Coronary artery (CA) inflammation leads to elastin breakdown, destruction of the vessel wall and aneurysm formation. We have demonstrated recently the pivotal role of tumour necrosis factor (TNF)-alpha-mediated matrix metalloproteinase (MMP)-9 activity in the pathogenesis of elastin breakdown in a murine model of KD, Lactobacillus casei cell wall extract-induced coronary arteritis. Using this model, we evaluated the in vitro effects of doxycycline, an antibiotic with MMP inhibitory function, in modulating key pathogenic stages of disease leading to CA damage. Doxycycline inhibits T cell activation and TNF-alpha production in peripheral immune cells, as assessed by thymidine incorporation and a TNF bioassay respectively. Additionally, doxycycline inhibits directly MMP-9 enzymatic activity derived from TNF-alpha-stimulated vascular smooth muscle cells as assayed by zymography. More importantly, in vivo treatment of Lactobacillus casei cell wall extract (LCWE)-injected mice with doxycycline reduces significantly the incidence of CA elastin breakdown and reduces loss of elastin. Therefore, doxycycline can mitigate TNF-alpha-induced MMP-9-mediated coronary elastin breakdown and improve coronary outcome. Agents with the ability to inhibit both inflammation and the downstream effects of inflammation, such as MMP-9 activity, offer a promising therapeutic strategy for the management of children with KD.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Lau AC,Duong TT,Ito S,Wilson GJ,Yeung RS

doi

10.1111/j.1365-2249.2009.03949.x

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

300-9

issue

2

eissn

0009-9104

issn

1365-2249

pii

CEI3949

journal_volume

157

pub_type

杂志文章

相关文献

CLINICAL AND EXPERIMENTAL IMMUNOLOGY文献大全
  • Excessive CD4+ T cells co-expressing interleukin-17 and interferon-γ in patients with Behçet's disease.

    abstract：:Excessive T helper type 1 (Th1) cell activity has been reported in Behçet's disease (BD). Recently, association of Th17 cells with certain autoimmune diseases was reported, and we thus investigated circulating Th17 cells in BD. CD4(+) CD45RO(-) (naive) T cells were cultured with Th0-, Th1-, Th2- and Th17-related cyto...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2011.04543.x

    authors： Shimizu J,Takai K,Fujiwara N,Arimitsu N,Ueda Y,Wakisaka S,Yoshikawa H,Kaneko F,Suzuki T,Suzuki N

    更新日期：2012-04-01 00:00:00

  • Mucosal and systemic immune responses to plasmid protein pgp3 in patients with genital and ocular Chlamydia trachomatis infection.

    abstract：:The circulating and cervical B cell responses to Chlamydia trachomatis plasmid protein pgp3 were characterized in children and adults with ocular or genital chlamydial infection using the enzyme-linked immunospot assay (ELISPOT) and ELISA. No pgp3-specific ASCs were detected in healthy controls, but predominantly IgA ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.2003.02163.x

    authors： Ghaem-Maghami S,Ratti G,Ghaem-Maghami M,Comanducci M,Hay PE,Bailey RL,Mabey DC,Whittle HC,Ward ME,Lewis DJ

    更新日期：2003-06-01 00:00:00

  • 5,7-dihydroxy-3,4,6-trimethoxyflavone inhibits the inflammatory effects induced by Bacteroides fragilis enterotoxin via dissociating the complex of heat shock protein 90 and I kappaB alpha and I kappaB kinase-gamma in intestinal epithelial cell culture.

    abstract：:Enterotoxin produced by enterotoxigenic Bacteroides fragilis (BFT) has been associated with mucosal inflammation and diarrhoeal diseases. In this study, the anti-inflammatory molecular mechanism of 5,7-dihydroxy-3,4,6-trimethoxyflavone (eupatilin) was characterized in an HT-29 intestinal epithelial cell line stimulate...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2008.03849.x

    authors： Kim JM,Lee DH,Kim JS,Lee JY,Park HG,Kim YJ,Oh YK,Jung HC,Kim SI

    更新日期：2009-03-01 00:00:00

  • Correlation of antibody to rheumatoid arthritis associated nuclear antigen and immune complexes to disease activity in patients with rheumatoid arthritis.

    abstract：:Twenty-seven patients with rheumatoid arthritis (RA) maintained on drug regimens were studied monthly for 6-10 months. Disease activity was assessed and levels of anti-RA associated nuclear antigen (RANA) and immune complexes were determined. Anti-RANA generally paralleled disease activity in 64% of cases. Immune comp...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Alspaugh MA,Rosenstock D,Biundo JJ,Gupta RC

    更新日期：1983-02-01 00:00:00

  • Serum amyloid P component and autoimmune parameters in the assessment of arthritis activity in MRL/lpr/lpr mice.

    abstract：:The concentration of immunoglobulins, anti-ssDNA, anti-dsDNA, anti-TNP antibodies, IgM rheumatoid factor, C3, immune complexes and serum amyloid P component (SAP), in the serum were measured in 68 male and female MRL/lpr/lpr mice, a strain affected with a systemic autoimmune disease. The degree of lymphoproliferation ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Rordorf-Adam C,Serban D,Pataki A,Grüninger M

    更新日期：1985-09-01 00:00:00

  • The Anisakis simplex Ani s 7 major allergen as an indicator of true Anisakis infections.

    abstract：:Ani s 7 is currently the most important excretory/secretory (ES) Anisakis simplex allergen, as it is the only one recognized by 100% of infected patients. The allergenicity of this molecule is due mainly to the presence of a novel CX(17-25)CX(9-22)CX(8)CX(6) tandem repeat motif not seen in any previously reported prot...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2009.03919.x

    authors： Anadón AM,Romarís F,Escalante M,Rodríguez E,Gárate T,Cuéllar C,Ubeira FM

    更新日期：2009-06-01 00:00:00

  • Abnormal intracellular IL-2 and interferon-gamma (IFN-gamma) production as HIV-1-assocated markers of immune dysfunction.

    abstract：:We used three-colour cytometry to analyse intracellular cytokine production in activated whole blood cultures derived from patients with HIV-1 infection. We assessed mitogen-induced IL-2, IL-4 and IFN-gamma production from T cells as possible markers of immune dysfunction. The percentages of T cells staining for IL-2 ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.1998.00505.x

    authors： Westby M,Marriott JB,Guckian M,Cookson S,Hay P,Dalgleish AG

    更新日期：1998-02-01 00:00:00

  • Distinct delta T cell receptor repertoires in monozygotic twins concordant for coeliac disease.

    abstract：:One of the hallmarks of coeliac disease, both active and treated, is an increased number and proportion of gamma/delta intraepithelial T lymphocytes in the small intestinal mucosa, and an increased number of gamma/delta T cells in the small intestinal mucosa of coeliac disease patients has been associated with the inh...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.1997.d01-887.x

    authors： Holtmeier W,Rowell DL,Nyberg A,Kagnoff MF

    更新日期：1997-01-01 00:00:00

  • Epitope shift of proteinase-3 anti-neutrophil cytoplasmic antibodies in patients with small vessel vasculitis.

    abstract：:Anti-neutrophil cytoplasmic antibodies against proteinase 3 (PR3-ANCA) are used as diagnostic tools for patients with small vessel vasculitis (AASV). We have produced chimeric mouse/human PR3 molecules and investigate changes in reactivity over time and the possible relationship between epitope specificity and clinica...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章,多中心研究

    doi：10.1111/j.1365-2249.2009.04063.x

    authors： Selga D,Segelmark M,Gunnarsson L,Hellmark T

    更新日期：2010-06-01 00:00:00

  • Detection and characterization of liver membrane autoantibodies in chronic active hepatitis by a solid-phase radioimmunoassay.

    abstract：:A solid-phase radioimmunoassay was developed to detect antibodies to liver membrane antigens in sera of patients with HBsAg-negative and -positive liver diseases and primary non-hepatic autoimmune diseases. Ten of fourteen patients with HBsAg-negative CAH had autoantibodies detected by RIA; negative results were obtai...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Manns M,Meyer zum Büschenfelde KH,Hütteroth TH,Hess G

    更新日期：1980-11-01 00:00:00

  • Efficacy, safety, tolerability and pharmacokinetics of a novel human immune globulin subcutaneous, 20%: a Phase 2/3 study in Europe in patients with primary immunodeficiencies.

    abstract：:A highly concentrated (20%) immunoglobulin (Ig)G preparation for subcutaneous administration (IGSC 20%), would offer a new option for antibody replacement therapy in patients with primary immunodeficiency diseases (PIDD). The efficacy, safety, tolerability and pharmacokinetics of IGSC 20% were evaluated in a prospecti...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章,多中心研究

    doi：10.1111/cei.12866

    authors： Borte M,Kriván G,Derfalvi B,Maródi L,Harrer T,Jolles S,Bourgeois C,Engl W,Leibl H,McCoy B,Gelmont D,Yel L

    更新日期：2017-01-01 00:00:00

  • Acute stress reduces intraparenchymal lung natural killer cells via beta-adrenergic stimulation.

    abstract：:There are lines of evidence that natural killer (NK) cells are sensitive to physical and psychological stress. Alterations in the immune system including NK cells are known to differ among tissues and organs. The effect of stress on the lung immune system, however, has not been well documented in spite of the fact tha...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2005.02672.x

    authors： Kanemi O,Zhang X,Sakamoto Y,Ebina M,Nagatomi R

    更新日期：2005-01-01 00:00:00

  • Beta-2-glycoprotein I expression on monocytes is increased in anti-phospholipid antibody syndrome and correlates with tissue factor expression.

    abstract：:It is well known that monocytes may play an active role in thrombogenesis, since they may express on their surface tissue factor, the major initiator of the clotting cascade. The results of this investigation demonstrate beta-2-glycoprotein I (beta2-GPI) mRNA expression by human peripheral blood monocytes, indicating ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.2003.02180.x

    authors： Conti F,Sorice M,Circella A,Alessandri C,Pittoni V,Caronti B,Calderaro C,Griggi T,Misasi R,Valesini G

    更新日期：2003-06-01 00:00:00

  • Complement-induced mixed aggregation of T and B lymphocytes and myeloid cells and the effect of adjuvant.

    abstract：:Complement induces mixed aggregation of murine spleen cells bearing C3 receptors. In the present studies, we show with immunofluorescent techniques that these aggregates are formed by T and B lymphocytes and myeloid cells, B cells constituting the predominant component in normal mice. There are striking changes in the...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Arnaiz-Villena A,Roitt IM

    更新日期：1975-07-01 00:00:00

  • Increased expression of class II antigens of the major histocompatibility complex on alveolar macrophages and alveolar type II cells and interleukin-1 (IL-1) secretion from alveolar macrophages in an animal model of silicosis.

    abstract：:Silicosis is a chronic progressive granulomatous and fibrotic lung disease caused by inhaled silica. Although the causative agent is known, the pathogenesis, especially the immunologic response, is not well understood. We examined two important components of cell-mediated immune responses in the lungs of rats with sil...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Struhar DJ,Harbeck RJ,Gegen N,Kawada H,Mason RJ

    更新日期：1989-08-01 00:00:00

  • Lymphocyte transformation test with rabbit liver specific lipoprotein (RLSP) in chronic active hepatitis.

    abstract：:Cellular sensitization to rabbit liver specific lipoprotein (RLSP) has been investigated using a lymphocyte transformation test in patients with chronic active hepatitis (CAH). A stimulation index greater than 2 was recorded in twenty out of twenty-five cases (eight of ten HBsAg positive and twelve of fiteen HBsAg neg...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Ortona L,Laghi V,Cauda R,Nervo P

    更新日期：1979-11-01 00:00:00

  • Reduced mitogenic responses in cultures of lymphocytes from newly calved cows.

    abstract：:The proliferative responses to stimulation with phytohaemagglutinin (PHA) in cultures of lymphocytes from newly calved and non-pregnant cattle were compared. Lymphocyte cultures from newly calved cows were seen to respond less to PHA than cultures from the non-pregnant cows. It is suggested that this depression in res...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Wells PW,Burrells C,Martin WB

    更新日期：1977-07-01 00:00:00

  • Avidity of thyroglobulin antibody in sera from patients with Hashimoto's thyroiditis with different thyroid functional status.

    abstract：:The mechanism of disease progression in Hashimoto's thyroiditis (HT) is still unclear. Thyroglobulin antibody (TgAb) is a diagnostic hallmark of HT. The aim of our study was to evaluate the avidity of TgAb in sera from HT patients with different thyroid functional status. Sera from 50 patients with newly diagnosed HT ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2010.04155.x

    authors： Zhang Y,Gao Y,Li M,Xie L,Huang Y,Gao Y,Guo X

    更新日期：2010-07-01 00:00:00

  • Calculated globulin (CG) as a screening test for antibody deficiency.

    abstract：:Calculated globulin (total protein - albumin) is usually tested as part of a liver function test profile in both primary and secondary care and determines the serum globulin concentration, of which immunoglobulins are a major component. The main use hitherto of calculated globulin is to detect paraproteins when the le...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.12369

    authors： Jolles S,Borrell R,Zouwail S,Heaps A,Sharp H,Moody M,Selwood C,Williams P,Phillips C,Hood K,Holding S,El Shanawany T

    更新日期：2014-09-01 00:00:00

  • High dose interleukin-12 exacerbates Bordetella pertussis infection and is associated with suppression of cell-mediated immunity in a murine aerosol challenge model.

    abstract：:The in-vivo clearance of Bordetella pertussis infections in murine models in naive mice and animals vaccinated with whole-cell vaccine is considered to be via a Th-1-dependent mechanism in which interleukin-12 (IL)-12 may play a prominent role. It has also been demonstrated clearly that the treatment of animals with m...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2003.02352.x

    authors： Carter CR,Dagg BM,Whitmore KM,Keeble JR,Asokanathan C,Xing D,Walker KB

    更新日期：2004-02-01 00:00:00

  • Humoral and cell-mediated immune responses in chronic typhoid carriers.

    abstract：:Humoral and cell-mediated immune responses to Salmonella typhi were studied in 10 chronic typhoid carriers, and in healthy controls. Carriers showed impaired cellular reactivity to S. typhi antigens in the leucocyte migration inhibition test (LMI). Carriers did not show a generalized depression of cell-mediated immuni...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Dham SK,Thompson RA

    更新日期：1982-10-01 00:00:00

  • The acquisition of anti-pneumococcal capsular polysaccharide Haemophilus influenzae type b and tetanus toxoid antibodies, with age, in the UK.

    abstract：:Antibody levels specific for capsular polysaccharides of Streptococcus pneumoniae and Haemophilus influenzae type b (Hib) and to tetanus toxoid (TT), were measured in serum samples of 750 age-stratified subjects from the UK. The study subjects comprised healthy adult volunteers and hospitalized children undergoing ele...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1993.tb07959.x

    authors： Hazlewood M,Nusrat R,Kumararatne DS,Goodall M,Raykundalia C,Wang DG,Joyce HJ,Milford-Ward A,Forte M,Pahor A

    更新日期：1993-08-01 00:00:00

  • Renal damage and death in weaned mice after oral infection with Shiga toxin 2-producing Escherichia coli strains.

    abstract：:Enterohaemorrhagic Escherichia coli (EHEC) O157:H7 infections are considered a public health problem in both developed and developing countries because of their increasing incidence and the severity of clinical presentation. Approximately 10% of infected patients develop complications such as haemolytic uraemic syndro...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2008.03698.x

    authors： Brando RJ,Miliwebsky E,Bentancor L,Deza N,Baschkier A,Ramos MV,Fernández GC,Meiss R,Rivas M,Palermo MS

    更新日期：2008-08-01 00:00:00

  • Oestrogen-induced suppression of collagen arthritis; 17 beta-oestradiol is therapeutically active in normal and castrated F1 hybrid mice of both sexes.

    abstract：:The F1 hybrid mouse strain, from B10Q and DBA/1 parentals (the QD strain), is highly susceptible to induction of type II collagen-induced arthritis, an experimental model for rheumatoid arthritis. Males are more susceptible than females. Oophorectomy enhances susceptibility to arthritis and treatment with physiologica...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1992.tb06978.x

    authors： Jansson L,Holmdahl R

    更新日期：1992-09-01 00:00:00

  • Long term spectrotypic and idiotypic stability of thyroglobulin autoantibodies in patients with Hashimoto's thyroiditis.

    abstract：:Isoelectric focusing of serial bleeds from patients with Hashimoto's thyroiditis was carried out and thyroglobulin (Tg) autoantibodies visualized using 125I-labelled Tg followed by autoradiography. Although the spectrotype of these antibodies was polyclonal and varied from patient to patient, each individual's spectro...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Delves PJ,Roitt IM

    更新日期：1988-03-01 00:00:00

  • Kupffer cell depletion in vivo results in preferential elimination of IgG aggregates and immune complexes via specific Fc receptors on rat liver endothelial cells.

    abstract：:In the present study we have investigated the clearance kinetics and tissue distribution of monomeric (m) IgG and soluble aggregates of IgG (AIgG) and immune complexes (IC) in normal and Kupffer cell (KC) depleted rats. In normal rats, clearance of mIgG occurred in a biphasic manner with a first half-life (T1/2) (T1) ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1991.tb05818.x

    authors： Bogers WM,Stad RK,Janssen DJ,van Rooijen N,van Es LA,Daha MR

    更新日期：1991-11-01 00:00:00

  • Natural and disease-specific autoantibodies in chronic obstructive pulmonary disease.

    abstract：:Autoimmunity may contribute to the pathogenesis of chronic obstructive pulmonary disease (COPD). Studies have identified disease-specific autoantibodies (DSAAbs) in COPD patients, but natural autoantibodies (NAAbs) may also play a role. Previous studies have concentrated on circulating autoantibodies, but lung-associa...

    journal_title：Clinical and experimental immunology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1111/cei.12565

    authors： Daffa NI,Tighe PJ,Corne JM,Fairclough LC,Todd I

    更新日期：2015-04-01 00:00:00

  • Differential response of human naive and memory/effector T cells to dendritic cells infected by respiratory syncytial virus.

    abstract：:In vitro studies have contributed substantially to the understanding of immunopathology of respiratory syncytial virus (RSV)-mediated disease. In the present study we compared the effect of RSV-infected dendritic cells on the time-course of the primary and memory/effector T cell response in vitro. Cultures with uninfe...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2007.03497.x

    authors： Rothoeft T,Fischer K,Zawatzki S,Schulz V,Schauer U,Körner Rettberg C

    更新日期：2007-11-01 00:00:00

  • Natural autoantibodies, IgG antibodies to tetanus toxoid and CD5+ B cells in patients with Mediterranean visceral leishmaniasis. The Leishmania Study Group.

    abstract：:Natural autoantibodies (NaAb) and IgG antibodies to tetanus toxoid (TT) were analysed in the sera of 38 children with active visceral leishmaniasis (VL) previously vaccinated with TT and in 30 healthy controls matched for sex and age. Patients exhibited high levels of NaAb to a panel of self antigens (tubulin, myosin,...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1994.tb07022.x

    authors： Louzir H,Belal-Kacemi L,Sassi A,Laouini D,Ben Ismail R,Dellagi K

    更新日期：1994-03-01 00:00:00

  • A syngeneic monoclonal anti-idiotype antibody against HNK-1: characterization and cytotoxic activity in vitro.

    abstract：:A syngeneic, monoclonal, anti-idiotype antibody, G6D9, was raised against the mouse monoclonal IgM HNK-1. G6D9, characterized as an IgG1-kappa, inhibits the binding of HNK-1 to the myelin-associated glycoprotein (MAG). G6D9 does not interfere with the binding of various human monoclonal anti-MAG IgM to their specific ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Schluep M,Page N,Burger D,Steck AJ

    更新日期：1989-02-01 00:00:00