Morphology of the corpus callosum in treatment-resistant schizophrenia and major depression.

Abstract:

OBJECTIVE:To identify possible differences in the mean midsagittal corpus callosum (CC) total and subdivision areas in treatment-resistant schizophrenia and depression (TRS and TRD) patients. METHOD:Areas of the total CC and its five equidistant subregions (from CC1 to CC5) obtained by parallel grid partitioning schemes were manually segmented from brain MRI of 42 TRS, 45 TRD patients and 30 healthy controls. The intracranial volume (ICV) normalized areas were calculated and compared between groups. RESULTS:When compared with controls, patients with TRS had reduced ICV and a larger CC5, and TRD patients had a smaller CC4 while no significant difference in CC total area in patients with TRS or TRD was found. Multiple individual segments and total CC areas were significantly larger in TRS than TRD patients after normalization. CONCLUSION:Patients with TRS and TRD have different CC morphological characteristics, and therefore there may be aberrant interhemispheric connectivity in schizophrenia and major depressive disorder patients.

journal_name

Acta Psychiatr Scand

authors

Sun J,Maller JJ,Daskalakis ZJ,Furtado CC,Fitzgerald PB

doi

10.1111/j.1600-0447.2009.01389.x

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

265-73

issue

4

eissn

0001-690X

issn

1600-0447

pii

ACP1389

journal_volume

120

pub_type

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