Metastatic calcification involving the true vocal cord.

Abstract:

:Metastatic calcification (MC) commonly results secondary to phosphorus and calcium dysregulation in end-stage renal disease (ESRD). Only once before has MC been reported to involve a true vocal cord. A 35-year-old man with ESRD and secondary hyperparathyroidism was evaluated for hoarseness. Three years ago, he underwent a total parathyroidectomy with parathyroid autograft to the forearm. Simultaneously, he had a left lobe thyroidectomy that displayed a papillary thyroid carcinoma. Since that time, he continued to have hyperphosphatemia and hypocalcemia. Laryngoscopy displayed a small papillomatous lesion on the right true vocal cord. He underwent excision of the vocal cord lesion; histologic examination demonstrated benign squamous epithelium with extensive submucosal calcification. In patients with ESRD with secondary dysregulation of serum phosphorus to calcium level balance, MC may involve variable anatomical locations, including the true vocal cords. Regarding histologic findings, pathologists must consider malignancies associated with calcification, mimicking a benign process.

journal_name

Am J Otolaryngol

authors

Patel NP,Wright SC,Bergman S

doi

10.1016/j.amjoto.2008.04.006

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

216-8

issue

3

eissn

0196-0709

issn

1532-818X

pii

S0196-0709(08)00068-9

journal_volume

30

pub_type

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