Abstract:
:Metastatic calcification (MC) commonly results secondary to phosphorus and calcium dysregulation in end-stage renal disease (ESRD). Only once before has MC been reported to involve a true vocal cord. A 35-year-old man with ESRD and secondary hyperparathyroidism was evaluated for hoarseness. Three years ago, he underwent a total parathyroidectomy with parathyroid autograft to the forearm. Simultaneously, he had a left lobe thyroidectomy that displayed a papillary thyroid carcinoma. Since that time, he continued to have hyperphosphatemia and hypocalcemia. Laryngoscopy displayed a small papillomatous lesion on the right true vocal cord. He underwent excision of the vocal cord lesion; histologic examination demonstrated benign squamous epithelium with extensive submucosal calcification. In patients with ESRD with secondary dysregulation of serum phosphorus to calcium level balance, MC may involve variable anatomical locations, including the true vocal cords. Regarding histologic findings, pathologists must consider malignancies associated with calcification, mimicking a benign process.
journal_name
Am J Otolaryngoljournal_title
American journal of otolaryngologyauthors
Patel NP,Wright SC,Bergman Sdoi
10.1016/j.amjoto.2008.04.006subject
Has Abstractpub_date
2009-05-01 00:00:00pages
216-8issue
3eissn
0196-0709issn
1532-818Xpii
S0196-0709(08)00068-9journal_volume
30pub_type
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journal_title:American journal of otolaryngology
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journal_title:American journal of otolaryngology
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